2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. CDK Carbonic Anhydrase
  4. CDK2-IN-12

CDK2-IN-12 (compound 10b) 是一种有效的 CDK2 抑制剂，其 IC50 为 11.6 μM。CDK2-IN-12 抑制 hCA 亚型 I、II、IX 和 XII，KI 值分别为 3534、638.4、44.3 和 48.8 nM。CDK2-IN-12 具有抗癌活性。

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CDK2-IN-12 Chemical Structure

CDK2-IN-12 Chemical Structure

CAS No. : 2410402-88-7

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CDK2-IN-12 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK2-IN-12 (compound 10b) is a potent CDK2 inhibitor, with an IC50 of 11.6 μM. CDK2-IN-12 inhibits hCA (carbonic anhydrase) isoforms I, II, IX and XII, with KI values of 3534, 638.4, 44.3, and 48.8 nM. CDK2-IN-12 shows anticancer activity[1].

IC50 & Target

CDK2

11.6 μM (IC50)

CDK9

>12.5 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
15.1 μM
Compound: 10b
Antiproliferative activity against human MCF7 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay
[PMID: 31972394]
MCF7 IC50
6.8 μM
Compound: 10b
Antiproliferative activity against human MCF7 cells measured after 48 hrs under normoxic condition by MTT assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs under normoxic condition by MTT assay
[PMID: 31972394]
MDA-MB-468 IC50
1.37 μM
Compound: 10b
Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under normoxic condition by MTT assay
Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under normoxic condition by MTT assay
[PMID: 31972394]
MDA-MB-468 IC50
3.03 μM
Compound: 10b
Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay
Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay
[PMID: 31972394]
体外研究
(In Vitro)

CDK2-IN-12 (compound 10b) exerts outstanding anti-proliferative activity against leukemia (CCRF-CEM, HL-60TB, K-562 and MOLT-4), non-small cell lung cancer (HOP-92), colon cancer (COLO 205, HCT-116 and SW-620), renal (ACHN) and breast (MDA-MB-468) cell lines with GI% (percentage growth inhibition) ranging from 80 to 100%[1].
CDK2-IN-12 displays much enhanced growth inhibitory activity, under normoxic and hypoxic conditions, against MDA-MB-468 (IC50 = 1.37 ± 0.07 and 3.03 ± 0.11 μM) than MCF-7 cells (IC50 = 6.80 ± 0.17 and 15.10 ± 0.82 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK2-IN-12 相关抗体:
分子量

447.47

Formula

C20H17N9O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK2-IN-12 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2-IN-122410402-88-7CDKCarbonic AnhydraseCyclin dependent kinaseCarbonate dehydratasecarbonic anhydrase inhibitorsPyrazolopyrimidinesImidazopyrazolesCAN508Inhibitorinhibitorinhibit

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