2. Cell Cycle/DNA Damage
  3. CDK
  4. (S)-Roscovitine

(S)-Roscovitine  (Synonyms: (S)-Seliciclib; (S)-CYC202)

目录号: HY-112403
产品使用指南

摩尔计算器

(S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) 是一种有效的可穿过血脑屏障的 CDKs 抑制剂。(S)-Roscovitine 具有神经保护功效。(S)-Roscovitine 具有用于中风研究的潜力。

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(S)-Roscovitine Chemical Structure

(S)-Roscovitine Chemical Structure

CAS No. : 186692-45-5

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Other Forms of (S)-Roscovitine:

(S)-Roscovitine 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S)-Roscovitine shows neuroprotective efficacy. (S)-Roscovitine has the potential for the research of stroke[1][2].

IC50 & Target[1]

CDK1

≤1 μM (IC50)

CDK2

≤1 μM (IC50)

CDK5

≤1 μM (IC50)

CDK7

≤1 μM (IC50)

CDK9

≤1 μM (IC50)

体内研究
(In Vivo)

(S)-Roscovitine (25 mg/kg; i.p.; 15 min before and 1 hr after pMCAo) 在永久性大脑中动脉闭塞 (permanent middle cerebral artery occlusion) 成年小鼠模型中显示出神经保护功效[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-25 g, P60 male C57 b/6 mice[2]
Dosage: 25 mg/kg
Administration: I.p.; at 15 min before and 1 hr after pMCAo
Result: Decreased of the total infarct volume.
分子量

354.45

Formula

C19H26N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(S)-Roscovitine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Roscovitine186692-45-5(S)-Seliciclib (S)-CYC202CDKCyclin dependent kinasePMCAoneuroprotectivecross the blood-brain barrierInhibitorinhibitorinhibit

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