2. Cell Cycle/DNA Damage
  3. CDK
  4. Olomoucine II

Olomoucine II 是一种有效的 CDK 抑制剂，对 CDK9/cyclin T, CDK2/cyclin E, CDK7/cyclin H, CDK1/cyclin B, CDK4/cyclin D1 的 IC50 值分别为 0.06、0.1、0.45、7.6 和 19.8 µM。Olomoucine II 具有抗增殖活性。

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Olomoucine II Chemical Structure

Olomoucine II Chemical Structure

CAS No. : 500735-47-7

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Olomoucine II 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Olomoucine II is a potent CDK inhibitor with IC50 values of 0.06, 0.1, 0.45, 7.6, 19.8 µM for CDK9/cyclin T, CDK2/cyclin E, CDK7/cyclin H, CDK1/cyclin B, CDK4/cyclin D1, respectively. Olomoucine II shows antiproliferative activity[1].

IC50 & Target[1]

CDK9/cycT

0.06 μM (IC50)

CDK2/cyclinE

0.1 μM (IC50)

CDK7/cyclin H

0.45 μM (IC50)

Cdk1/cyclin B

7.6 μM (IC50)

CDK4/cyclinD1

19.8 μM (IC50)

体外研究
(In Vitro)

Olomoucine II (72 h) 显示出抗增殖活性，对 HOS、T98G、HBL100、BT474、MCF-7、HT-29、CCRF-CEM、BV173 和 HL60 细胞的 IC50 值分别为 9.3、9.2、10.5、13.6、5.0、10.8、5.3、2.7、16.3 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Olomoucine II 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HOS, T98G, HBL100, BT474, MCF-7, HT-29, CCRF-CEM, BV173, HL60 cells
Concentration:
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s of 9.3, 9.2, 10.5, 13.6, 5.0, 10.8, 5.3, 2.7, 16.3 µM for HOS, T98G, HBL100, BT474, MCF-7, HT-29, CCRF-CEM, BV173, HL60 cells, respectively.
分子量

370.45

Formula

C19H26N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Olomoucine II 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olomoucine II500735-47-7CDKCyclin dependent kinaseantiproliferativeArn8 cellsp53p21Inhibitorinhibitorinhibit

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