2. Cell Cycle/DNA Damage
  3. CDK
  4. Olomoucine II

Olomoucine II 是一种有效的 CDK 抑制剂，对 CDK9/cyclin T, CDK2/cyclin E, CDK7/cyclin H, CDK1/cyclin B, CDK4/cyclin D1 的 IC50 值分别为 0.06、0.1、0.45、7.6 和 19.8 µM。Olomoucine II 具有抗增殖活性。

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Olomoucine II Chemical Structure

Olomoucine II Chemical Structure

CAS No. : 500735-47-7

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Olomoucine II 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Olomoucine II is a potent CDK inhibitor with IC50 values of 0.06, 0.1, 0.45, 7.6, 19.8 µM for CDK9/cyclin T, CDK2/cyclin E, CDK7/cyclin H, CDK1/cyclin B, CDK4/cyclin D1, respectively. Olomoucine II shows antiproliferative activity[1].

IC50 & Target[1]

CDK9/cycT

0.06 μM (IC50)

CDK2/cyclinE

0.1 μM (IC50)

CDK7/cyclin H

0.45 μM (IC50)

Cdk1/cyclin B

7.6 μM (IC50)

CDK4/cyclinD1

19.8 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BJ EC50
5.4 μM
Compound: olomoucine II
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
CCRF-CEM IC50
7.4 μM
Compound: Olomoucine II
Cytotoxicity against human CEM cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
Cytotoxicity against human CEM cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
[PMID: 22770608]
CCRF-CEM EC50
8.1 μM
Compound: olomoucine II
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
G-361 IC50
9.2 μM
Compound: Olomoucine II
Cytotoxicity against human G361 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
Cytotoxicity against human G361 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
[PMID: 22770608]
HCT-116 IC50
4.1 μM
Compound: Olomoucine II
Cytotoxicity against human HCT116 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
Cytotoxicity against human HCT116 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
[PMID: 22770608]
HeLa EC50
9.9 μM
Compound: olomoucine II
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
HOS IC50
10.6 μM
Compound: Olomoucine II
Cytotoxicity against human HOS cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
Cytotoxicity against human HOS cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
[PMID: 22770608]
K562 IC50
23 μM
Compound: Olomoucine II
Cytotoxicity against human K562 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
Cytotoxicity against human K562 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
[PMID: 22770608]
MCF7 EC50
4.6 μM
Compound: olomoucine II
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
MCF7 IC50
9.1 μM
Compound: Olomoucine II
Cytotoxicity against human MCF7 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
Cytotoxicity against human MCF7 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
[PMID: 22770608]
RPMI-8226 EC50
6 μM
Compound: olomoucine II
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
Sf9 IC50
50 nM
Compound: Olomoucine II
Inhibition of CDK2/Cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate
Inhibition of CDK2/Cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate
[PMID: 22770608]
U-266 EC50
7.2 μM
Compound: olomoucine II
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
体外研究
(In Vitro)

Olomoucine II (72 h) 显示出抗增殖活性，对 HOS、T98G、HBL100、BT474、MCF-7、HT-29、CCRF-CEM、BV173 和 HL60 细胞的 IC50 值分别为 9.3、9.2、10.5、13.6、5.0、10.8、5.3、2.7、16.3 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Olomoucine II 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HOS, T98G, HBL100, BT474, MCF-7, HT-29, CCRF-CEM, BV173, HL60 cells
Concentration:
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s of 9.3, 9.2, 10.5, 13.6, 5.0, 10.8, 5.3, 2.7, 16.3 µM for HOS, T98G, HBL100, BT474, MCF-7, HT-29, CCRF-CEM, BV173, HL60 cells, respectively.
分子量

370.45

Formula

C19H26N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Olomoucine II 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olomoucine II500735-47-7CDKCyclin dependent kinaseantiproliferativeArn8 cellsp53p21Inhibitorinhibitorinhibit

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