2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. PROTAC CDK9 degrader-5

PROTAC CDK9 degrader-5 是一种特异性靶向 CDK9 的 PROTAC。PROTAC CDK9 degrader-5 通过蛋白酶体介导 CDK9 降解。PROTAC CDK9 degrader-5 降解 CDK9，对 CDK942 和 CDK955 异构体的 DC50 分别为 0.10 μM 和 0.14 μM。

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PROTAC CDK9 degrader-5 Chemical Structure

PROTAC CDK9 degrader-5 Chemical Structure

CAS No. : 2935587-89-4

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PROTAC CDK9 degrader-5 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC CDK9 degrader-5 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-5 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-5 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively[1].

IC50 & Target[1]

CDK942

0.10 μM (DC50)

CDK955

0.14 μM (DC50)

体外研究
(In Vitro)

PROTAC CDK9 degrader-5 (compound 15e) (1 μM；6 小时) 降低 MCL2 的蛋白质水平，并竞争性降解 MV411 细胞中的 CDK9[1]。
PROTAC CDK9 degrader-5 (1 μM；1-6 小时) 时间依赖性地降低 MCL2 和 CDK9 的蛋白质水平，并保持 24 小时抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC CDK9 degrader-5 相关抗体:

Western Blot Analysis[1]

Cell Line: MV411 cells
Concentration: 1 μM
Incubation Time: 1 h, 2 h, 4 h, 6 h
Result: Degraded CDK9 starting at 2 h incubation and reaching a plateau at 4 h.
Remained suppressed for 24 h with some recurrence at 48 h after finished treatment.
分子量

879.78

Formula

C42H48Cl2N8O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC CDK9 degrader-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC CDK9 degrader-52935587-89-4PROTACsCDKCyclin dependent kinaseInhibitorinhibitorinhibit

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产品名称：
PROTAC CDK9 degrader-5
目录号：
HY-149962
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