2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. ZLWT-37

ZLWT-37 是一种有效的、具有口服活性的 CDKs 抑制剂，对 CDK9 和 CDK2 的 IC50 分别为 0.002 μM 和 0.054 μM。ZLWT-37 诱导 HCT116 细胞凋亡 (apoptosis)，在 G2/M 期阻滞细胞周期。

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ZLWT-37 Chemical Structure

ZLWT-37 Chemical Structure

CAS No. : 2813347-44-1

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ZLWT-37 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZLWT-37 is a potent, orally active CDKs inhibitor with IC50 values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells[1].

IC50 & Target

CDK9

0.002 μM (IC50)

CDK2

0.054 μM (IC50)

体外研究
(In Vitro)

ZLWT-37 shows antiproliferative activity with a GI50 of 0.029 μM for HCT116[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZLWT-37 相关抗体:
体内研究
(In Vivo)

ZLWT-37 (0-20 mg/kg; p.o.; once daily for 14 consecutive days) shows potential efficacy against the growth of implanted HCT116 cells in mice without obvious toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

464.00

Formula

C26H30ClN5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZLWT-37 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLWT-372813347-44-1ZLWT37ZLWT 37CDKApoptosisCyclin dependent kinaseAChECDK9CDK2anti-cancerHCT116low toxicityInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-147771
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