2. Cell Cycle/DNA Damage
  3. CDK
  4. IIIM-290

IIIM-290是有效，可口服的 CDK 抑制剂，对CDK2/A和CDK9/T1的IC50分别为90和94 nM。

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IIIM-290 Chemical Structure

IIIM-290 Chemical Structure

CAS No. : 2213468-64-3

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IIIM-290 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IIIM-290 is a potent and oral CDK inhibitor with IC50s of 90 and 94 nM for CDK2/A and CDK9/T1.

IC50 & Target[1]

CDK2/A

90 nM (IC50)

CDK9/T1

94 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
786-0 GI50
6 μM
Compound: 11d
Growth inhibition of human 786-0 cells after 48 hrs by MTT assay
Growth inhibition of human 786-0 cells after 48 hrs by MTT assay
[PMID: 29370702]
A-431 GI50
8 μM
Compound: 11d
Growth inhibition of human A431 cells after 48 hrs by MTT assay
Growth inhibition of human A431 cells after 48 hrs by MTT assay
[PMID: 29370702]
A549 GI50
4 μM
Compound: 11d
Growth inhibition of human A549 cells after 48 hrs by MTT assay
Growth inhibition of human A549 cells after 48 hrs by MTT assay
[PMID: 29370702]
BT-549 GI50
5 μM
Compound: 11d
Growth inhibition of human BT549 cells after 48 hrs by MTT assay
Growth inhibition of human BT549 cells after 48 hrs by MTT assay
[PMID: 29370702]
Caco-2 GI50
7 μM
Compound: 11d
Growth inhibition of human Caco2 cells after 48 hrs by MTT assay
Growth inhibition of human Caco2 cells after 48 hrs by MTT assay
[PMID: 29370702]
COLO 205 GI50
7 μM
Compound: 11d
Growth inhibition of human COLO205 cells after 48 hrs by MTT assay
Growth inhibition of human COLO205 cells after 48 hrs by MTT assay
[PMID: 29370702]
DU-145 GI50
5 μM
Compound: 11d
Growth inhibition of human DU145 cells after 48 hrs by MTT assay
Growth inhibition of human DU145 cells after 48 hrs by MTT assay
[PMID: 29370702]
HCT-116 GI50
5 μM
Compound: 11d
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
[PMID: 29370702]
HEK293 IC50
> 50 μM
Compound: 11d
Inhibition of [3H]-astemizole binding to human ERG expressed in HEK293 cell membranes by scintillation counting method
Inhibition of [3H]-astemizole binding to human ERG expressed in HEK293 cell membranes by scintillation counting method
[PMID: 29370702]
HEK293 GI50
22 μM
Compound: 11d
Growth inhibition of human HEK293 cells after 48 hrs by MTT assay
Growth inhibition of human HEK293 cells after 48 hrs by MTT assay
[PMID: 29370702]
HL-60 GI50
0.9 μM
Compound: 11d
Growth inhibition of human HL60 cells after 48 hrs by MTT assay
Growth inhibition of human HL60 cells after 48 hrs by MTT assay
[PMID: 29370702]
HOP-62 GI50
7 μM
Compound: 11d
Growth inhibition of human HOP62 cells after 48 hrs by MTT assay
Growth inhibition of human HOP62 cells after 48 hrs by MTT assay
[PMID: 29370702]
HOP-92 GI50
3 μM
Compound: 11d
Growth inhibition of human HOP92 cells after 48 hrs by MTT assay
Growth inhibition of human HOP92 cells after 48 hrs by MTT assay
[PMID: 29370702]
LOX IMVI GI50
4 μM
Compound: 11d
Growth inhibition of human LOXIMVI cells after 48 hrs by MTT assay
Growth inhibition of human LOXIMVI cells after 48 hrs by MTT assay
[PMID: 29370702]
MCF7 GI50
4 μM
Compound: 11d
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
[PMID: 29370702]
MDA-MB-231 GI50
4 μM
Compound: 11d
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 29370702]
MDA-MB-468 GI50
4 μM
Compound: 11d
Growth inhibition of human MDA-MB-468 cells after 48 hrs by MTT assay
Growth inhibition of human MDA-MB-468 cells after 48 hrs by MTT assay
[PMID: 29370702]
MIA PaCa-2 GI50
1 μM
Compound: 11d
Growth inhibition of human MIAPaCa2 cells after 48 hrs by MTT assay
Growth inhibition of human MIAPaCa2 cells after 48 hrs by MTT assay
[PMID: 29370702]
MOLT-4 GI50
0.5 μM
Compound: 11d
Growth inhibition of human MOLT4 cells after 48 hrs by MTT assay
Growth inhibition of human MOLT4 cells after 48 hrs by MTT assay
[PMID: 29370702]
NCI-H226 GI50
4 μM
Compound: 11d
Growth inhibition of human NCI-H226 cells after 48 hrs by MTT assay
Growth inhibition of human NCI-H226 cells after 48 hrs by MTT assay
[PMID: 29370702]
NCI-H522 GI50
5 μM
Compound: 11d
Growth inhibition of human NCI-H522 cells after 48 hrs by MTT assay
Growth inhibition of human NCI-H522 cells after 48 hrs by MTT assay
[PMID: 29370702]
OVCAR-3 GI50
8 μM
Compound: 11d
Growth inhibition of human OVCAR3 cells after 48 hrs by MTT assay
Growth inhibition of human OVCAR3 cells after 48 hrs by MTT assay
[PMID: 29370702]
OVCAR-4 GI50
9 μM
Compound: 11d
Growth inhibition of human OVCAR4 cells after 48 hrs by MTT assay
Growth inhibition of human OVCAR4 cells after 48 hrs by MTT assay
[PMID: 29370702]
OVCAR-5 GI50
7 μM
Compound: 11d
Growth inhibition of human OVCAR5 cells after 48 hrs by MTT assay
Growth inhibition of human OVCAR5 cells after 48 hrs by MTT assay
[PMID: 29370702]
PANC-1 GI50
4 μM
Compound: 11d
Growth inhibition of human PANC1 cells after 48 hrs by MTT assay
Growth inhibition of human PANC1 cells after 48 hrs by MTT assay
[PMID: 29370702]
PC-3 GI50
3 μM
Compound: 11d
Growth inhibition of human PC3 cells after 48 hrs by MTT assay
Growth inhibition of human PC3 cells after 48 hrs by MTT assay
[PMID: 29370702]
T47D GI50
6 μM
Compound: 11d
Growth inhibition of human T47D cells after 48 hrs by MTT assay
Growth inhibition of human T47D cells after 48 hrs by MTT assay
[PMID: 29370702]
分子量

462.32

Formula

C23H21Cl2NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IIIM-290 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IIIM-2902213468-64-3IIIM290IIIM 290CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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目录号：
HY-111356
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