AKAP11 - A-kinase anchoring protein 11 Gene

中文名称：A-激酶锚定蛋白 11

种属: Homo sapiens

同用名: PRKA11; AKAP-11; AKAP220; PPP1R44

关于 AKAP11

功能概要

激酶锚定蛋白 (AKAP) 是一组结构多样的蛋白质，它们具有与蛋白激酶 A (PKA) 的调节亚基结合并将全酶限制在细胞内离散位置的共同功能。该基因编码 AKAP 家族的一个成员。编码的蛋白质在整个精子发生过程和成熟精子中以高水平表达。它结合睾丸中 PKA 的 RI 和 RII 亚基。除了其在精子发生和精子功能中的推定作用外，它还可能在体细胞和生殖细胞的细胞周期控制中发挥作用。[RefSeq 提供，2008 年 7 月]

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]