RCHY1 - ring finger and CHY zinc finger domain containing 1 Gene

中文名称：含无名指和 CHY 锌指结构域 1

种属: Homo sapiens

同用名: ZCHY; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; PRO1996

基因 ID: 25898 | 基因类型: protein coding

关于 RCHY1

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,479,033-75,514,715 (from NCBI)

This gene has 13 transcripts (splice variants) and 155 orthologues. Ubiquitous expression in thyroid (RPKM 7.9), bone marrow (RPKM 6.3) and 25 other tissues.

功能概要

该基因编码的蛋白质具有泛素连接酶活性。它介导靶蛋白的 E3 依赖性泛素化和蛋白酶体降解，包括肿瘤蛋白 53、组蛋白脱乙酰酶 1 和细胞周期蛋白依赖性激酶抑制剂 1B，从而调节它们的水平和细胞周期进程。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2013 年 6 月]

The protein encoded by this gene has ubiquitin Ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

RCHY1 基因产物(8)

mRNA	Protein	Name
NM_001009922.3	NP_001009922.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 3
NM_001278536.2	NP_001265465.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 4
NM_001278537.2	NP_001265466.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 5
NM_001278538.2	NP_001265467.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 6
NM_001278539.2	NP_001265468.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 7
NM_001387136.1	NP_001374065.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 7
NM_001387137.1	NP_001374066.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 7
NM_015436.4	NP_056251.2	RING finger and CHY zinc finger domain-containing protein 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables p53 binding	IPI IPI: 通过物理相互作用推断	19043414	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15781263	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	19483087	GOA
NOT enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	20452352	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	19483087	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	19043414	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	19483087	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: 通过直接分析推断	19483087	GOA
involved in protein autoubiquitination	IDA IDA: 通过直接分析推断	19483087	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	19043414	GOA
involved in rescue of stalled ribosome	IDA IDA: 通过直接分析推断	33909987	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	19483087	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15781263	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19483087	GOA
part of ubiquitin ligase complex	IDA IDA: 通过直接分析推断	19043414	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RCHY1 蛋白结构

zf-CHY

zf-RING_2

zinc_ribbon_6

0
100
200
261 a.a.

蛋白主名

其他名称

RING finger and CHY zinc finger domain-containing protein 1

CH-rich interacting match with PLAG1

RCHY1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RCHY1	Q96PM5	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	25416956
Intra	RCHY1	Q96PM5	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	RCHY1	Q96PM5	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	25416956
Intra	RCHY1	Q96PM5	LIMS2	Homo sapiens	Q7Z4I7-5	Y2H Array	25416956
Intra	RCHY1	Q96PM5	SEMA4C	Homo sapiens	Q9C0C4	Y2H Prey Pooling	25416956
Intra	RCHY1	Q96PM5	SEMA4C	Homo sapiens	Q9C0C4	Y2H Array	25416956
Intra	RCHY1	Q96PM5	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
Intra	RCHY1	Q96PM5	ARF4	Homo sapiens	P18085	Pull Down	21988832
Intra	RCHY1	Q96PM5	ARF4	Homo sapiens	P18085	Confocal	21988832
Intra	RCHY1	Q96PM5	ARF4	Homo sapiens	P18085	Y2H	21988832
Intra	RCHY1	Q96PM5	UBASH3B	Homo sapiens	Q8TF42	Anti Tag CoIP	33961781
Intra	RCHY1	Q96PM5	UBASH3B	Homo sapiens	Q8TF42	Y2H Array	25416956
Intra	RCHY1	Q96PM5	NKD2	Homo sapiens	Q969F2	Y2H	21988832
Intra	RCHY1	Q96PM5	NKD2	Homo sapiens	Q969F2	Anti Tag CoIP	21988832
Cross	RCHY1	Q96PM5	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	Anti Tag CoIP	27519799
Cross	RCHY1	Q96PM5	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	BiFC	27519799
Intra	RCHY1	Q96PM5	CAMK2D	Homo sapiens	Q13557	Anti Tag CoIP	27519799
Intra	RCHY1	Q96PM5	TP53	Homo sapiens	P04637	Anti Tag CoIP	17568776
Intra	RCHY1	Q96PM5	TP53	Homo sapiens	P04637	Anti Tag CoIP	20452352
Intra	RCHY1	Q96PM5	NLK	Homo sapiens	Q9UBE8	Anti Tag CoIP	21988832
Intra	RCHY1	Q96PM5	NLK	Homo sapiens	Q9UBE8	Y2H	21988832
Intra	RCHY1	Q96PM5	NLK	Homo sapiens	Q9UBE8	Pull Down	21988832
Intra	RCHY1	Q96PM5	HRG	Homo sapiens	P04196	Anti Tag CoIP	21988832
Intra	RCHY1	Q96PM5	AIG1	Homo sapiens	Q9NVV5	Pull Down	21988832
Intra	RCHY1	Q96PM5	AIG1	Homo sapiens	Q9NVV5	Y2H	21988832
Intra	RCHY1	Q96PM5	AIG1	Homo sapiens	Q9NVV5	Anti Tag CoIP	21988832
Intra	RCHY1	Q96PM5	ANGPTL8	Homo sapiens	Q6UXH0	Y2H	21988832
Intra	RCHY1	Q96PM5	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RCHY1	Q96PM5	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RCHY1	Q96PM5	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RCHY1	Q96PM5	KLHL41	Homo sapiens	O60662	Y2H Prey Pooling	25416956
Intra	RCHY1	Q96PM5	KLHL41	Homo sapiens	O60662	Y2H Array	25416956
Intra	RCHY1	Q96PM5	WDR74	Homo sapiens	Q6RFH5	Y2H Prey Pooling	25416956
Intra	RCHY1	Q96PM5	WDR74	Homo sapiens	Q6RFH5	Y2H Array	25416956
Intra	RCHY1	Q96PM5	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	RCHY1	Q96PM5	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Cross	RCHY1	Q96PM5	K9N7C7-PRO_0000422441	Middle East respiratory syndrome-related coronavirus	K9N7C7-PRO_0000422441	Anti Tag CoIP	27519799

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11786	RCHY1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	RCHY1	VGNC	VGNC:64549
Bos taurus	RCHY1	VGNC	VGNC:33829
Rattus norvegicus	RCHY1	RGD	RGD:1359180
Canis familiaris	RCHY1	VGNC	VGNC:45443
Macaca mulatta	RCHY1	VGNC	VGNC:76753
Mus musculus	RCHY1	MGD	MGI:1915348

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4