NKD2 - NKD inhibitor of WNT signaling pathway 2 Gene

中文名称：WNT 信号通路 2 的 NKD 抑制因子

种属: Homo sapiens

同用名: Naked2

基因 ID: 85409 | 基因类型: protein coding

关于 NKD2

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:1,008,802-1,038,943 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 194 orthologues and 1 paralogue. Broad expression in lung (RPKM 6.0), skin (RPKM 2.9) and 15 other tissues.

功能概要

该基因编码一个蛋白质家族的成员，该蛋白质家族通过与 Disheveled 家族成员的相互作用充当 Wnt 受体信号传导的负调节因子。编码的蛋白质参与将含有转化生长因子 α 的囊泡递送至细胞膜。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

NKD2 基因产物(2)

mRNA	Protein	Name
NM_001271082.2	NP_001258011.1	protein naked cuticle homolog 2 isoform 2
NM_033120.4	NP_149111.1	protein naked cuticle homolog 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATPase binding	IPI IPI: 通过物理相互作用推断	18504258	GOA
enables growth factor binding	IPI IPI: 通过物理相互作用推断	15064403	GOA
enables molecular adaptor activity	EXP EXP: 通过实验结果推断	17045239	GOA
enables myosin heavy chain binding	IPI IPI: 通过物理相互作用推断	18504258	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15064403	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	18757723	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi vesicle fusion to target membrane	IMP IMP: 通过突变表型推断	17553928	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	20177058	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	15687260	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	20177058	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: 通过直接分析推断	15064403	GOA
involved in positive regulation of protein processing	IDA IDA: 通过直接分析推断	15064403	GOA
involved in protein localization to plasma membrane	IMP IMP: 通过突变表型推断	17553928	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	17553928	GOA
located in cell periphery	IDA IDA: 通过直接分析推断	15064403	GOA
located in cytoplasmic vesicle	IDA IDA: 通过直接分析推断	15064403	GOA
located in exocytic vesicle	IDA IDA: 通过直接分析推断	18504258	GOA
located in lateral plasma membrane	IDA IDA: 通过直接分析推断	20177058	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	18504258	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

protein naked cuticle homolog 2

Dvl-binding protein NKD2

NKD2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NKD2	Q969F2	TGFA	Homo sapiens	P01135	Y2H	15064403
Intra	NKD2	Q969F2	RNF25	Homo sapiens	Q96BH1	Anti Bait CoIP	18757723
Intra	NKD2	Q969F2	RNF25	Homo sapiens	Q96BH1	Anti Tag CoIP	18757723

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09318	NKD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	NKD2	VGNC	VGNC:63814
Rattus norvegicus	NKD2	RGD	RGD:1311459
Macaca mulatta	NKD2	VGNC	VGNC:75199
Mus musculus	NKD2	MGD	MGI:1919543
Bos taurus	NKD2	VGNC	VGNC:59353
Canis familiaris	NKD2	VGNC	VGNC:54105

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NKD2 - NKD inhibitor of WNT signaling pathway 2 Gene

关于 NKD2

功能概要

NKD2 基因产物(2)

NKD2 蛋白互作信息

关联疾病

直系同源

热门区域

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NKD2 - NKD inhibitor of WNT signaling pathway 2 Gene

关于 NKD2

功能概要

NKD2 基因产物(2)

NKD2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z