2. Gene
  3. RNF25 - ring finger protein 25 Gene

RNF25 - ring finger protein 25 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：无名指蛋白 25

种属: Homo sapiens

同用名: AO7

基因 ID: 64320 | 基因类型: protein coding

关于 RNF25

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,663,892-218,672,002 (from NCBI)

This gene has 6 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in testis (RPKM 11.2), thyroid (RPKM 8.7) and 25 other tissues.

功能概要

该基因编码的蛋白质包含一个无名指基序。这种蛋白质的小鼠对应物已被证明与 Rela 相互作用，Rela 是 NF-kappaB (NFKB) 的 p65 亚基，并调节 NFKB 介导的转录活性。小鼠蛋白还结合泛素结合酶 (E2) ，是 E2 依赖性泛素化的底物。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating Enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]

RNF25 基因产物(1)

mRNA Protein Name
NM_022453.3 NP_071898.2 E3 ubiquitin-protein ligase RNF25
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NF-kappaB binding IPI
IPI: 通过物理相互作用推断
12748188 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18757723 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
26475854 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
12748188 GOA
involved in protein K6-linked ubiquitination IDA
IDA: 通过直接分析推断
27863242 GOA
involved in protein-RNA covalent cross-linking repair IDA
IDA: 通过直接分析推断
37951215 GOA
involved in rescue of stalled ribosome IDA
IDA: 通过直接分析推断
27863242 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
27863242 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
12748188 GOA
is active in cytosolic ribosome IDA
IDA: 通过直接分析推断
27863242 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12748188 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF25 蛋白结构

RWD

RWD: RWD domain (18 - 123)

zf-RING_2

zf-RING_2: Ring finger domain (134 - 202)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 459 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF25

RING-type E3 ubiquitin transferase RNF25

RNF25 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RNF25 Q96BH1 KCTD21 Homo sapiens Q4G0X4
Y2H Prey Pooling
32296183
种属内
RNF25 Q96BH1 KCTD21 Homo sapiens Q4G0X4
Y2H Array
32296183
种属内
RNF25 Q96BH1 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
RNF25 Q96BH1 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
RNF25 Q96BH1 UBE2E2 Homo sapiens Q96LR5
Anti Tag CoIP
33961781
种属内
RNF25 Q96BH1 UBE2D2 Homo sapiens P62837
Anti Tag CoIP
33961781
种属内
RNF25 Q96BH1 UBE2D2 Homo sapiens P62837
Y2H Array
19690564
种属内
RNF25 Q96BH1 UBE2D3 Homo sapiens P61077
Y2H Array
19690564
种属内
RNF25 Q96BH1 UBE2D3 Homo sapiens P61077
Anti Tag CoIP
33961781
种属内
RNF25 Q96BH1 UBE2D3 Homo sapiens P61077
Y2H Array
19549727
种属内
RNF25 Q96BH1 UBE2E3 Homo sapiens Q969T4
Anti Tag CoIP
33961781
种属内
RNF25 Q96BH1 UBE2E3 Homo sapiens Q969T4
Y2H Array
19690564
种属内
RNF25 Q96BH1 UBE2E1 Homo sapiens P51965
Y2H Array
19690564
种属内
RNF25 Q96BH1 UBE2E1 Homo sapiens P51965
Y2H Array
19549727
种属内
RNF25 Q96BH1 UBE2E1 Homo sapiens P51965
Anti Tag CoIP
33961781
种属内
RNF25 Q96BH1 UBE2E1 Homo sapiens P51965
Anti Tag CoIP
28514442
种属内
RNF25 Q96BH1 UBE2D1 Homo sapiens P51668
Y2H Array
19549727
种属内
RNF25 Q96BH1 UBE2D4 Homo sapiens Q9Y2X8
Anti Tag CoIP
33961781
种属内
RNF25 Q96BH1 UBE2D4 Homo sapiens Q9Y2X8
Anti Tag CoIP
28514442
种属内
RNF25 Q96BH1 UBE2D4 Homo sapiens Q9Y2X8
Y2H Array
19690564
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypomagnesemia 3, Renal

HOMG3

Renal Hypomagnesemia 3

Fhhnc Without Severe Ocular Involvement

Renal Hypomagnesemia Type 3

Hypomagnesemia, Primary, Due To Defect In Renal Tubular Transport Of Magnesium

Hypomagnesemia, Isolated Renal

Hypomagnesemia, Familial, With Hypercalciuria And Nephrocalcinosis

Familial Primary Hypomagnesemia With Hypercalciuria And Nephrocalcinosis Without Severe Ocular Involvement

Isolated Renal Hypomagnesemia

Primary Hypomagnesemia Due To Defect In Renal Tubular Transport Of Magnesium

Primary Hypomagnesemia With Hypercalciuria And Nephrocalcinosis Without Severe Ocular Involvement

Hypomagnesemia 3

Familial Hypomagnesemia With Hypercalciuria And Nephrocalcinosis

Fhhnc

Hhn

Renal Hypomagnesemia Hypercalciuria Nephrocalcinosis

Hypomagnesemia, Type 3, Renal

Primary Hypomagnesemia
Progesterone-Receptor Positive Breast Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12084 RNF25 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RNF25 VGNC VGNC:76736
Bos taurus RNF25 VGNC VGNC:34060
Rattus norvegicus RNF25 RGD RGD:1311557
Felis catus RNF25 VGNC VGNC:64698
Mus musculus RNF25 MGD MGI:1890215
Canis familiaris RNF25 VGNC VGNC:45665
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