2. Gene
  3. UBE2E1 - ubiquitin conjugating enzyme E2 E1 Gene

UBE2E1 - ubiquitin conjugating enzyme E2 E1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素结合酶 E2 E1

种属: Homo sapiens

同用名: UBCH6

基因 ID: 7324 | 基因类型: protein coding

关于 UBE2E1

Cytogenetic location: 3p24.2 Genomic coordinates (GRCh38): 3:23,805,955-23,891,640 (from NCBI)

This gene has 11 transcripts (splice variants), 148 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 26.5), brain (RPKM 25.3) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。已经为该基因发现了编码不同同种型的三个可变剪接的转录物变体。[RefSeq 提供，2011 年 1 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

UBE2E1 基因产物(3)

mRNA Protein Name
NM_001202476.2 NP_001189405.1 ubiquitin-conjugating enzyme E2 E1 isoform 3
NM_003341.5 NP_003332.1 ubiquitin-conjugating enzyme E2 E1 isoform 1
NM_182666.3 NP_872607.1 ubiquitin-conjugating enzyme E2 E1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ISG15 transferase activity IDA
IDA: 通过直接分析推断
16428300 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16307923 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: 通过直接分析推断
15247280 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
16307923 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ISG15-protein conjugation IDA
IDA: 通过直接分析推断
16428300 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16307923 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
15247280 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
9990509 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
18845142 GOA
part of ubiquitin ligase complex IDA
IDA: 通过直接分析推断
16307923 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBE2E1 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (51 - 187)

  • 0
  • 100
  • 193 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 E1

(E3-independent) E2 ubiquitin-conjugating enzyme E1

关联疾病

疾病名称 别名
Limb-Girdle Muscular Dystrophy

Lgmd

Limb Girdle Muscular Dystrophy

Muscular Dystrophies, Limb-Girdle

Erb'S Muscular Dystrophy

Leyden-Mbius Muscular Dystrophy

Limb-Girdle Syndrome

Myopathic Limb-Girdle Syndrome

Limb Girdle

Muscular Dystrophy Limb-Girdle

Dystrophy, Muscular, Limb-Girdle

Lgmd - [Limb-Girdle Muscular Dystrophy]

Limb Girdle Muscle Dystrophy

Limb-Girdle Myopathy
Immunodeficiency 33

IMD33

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency

X-Linked Msmd Due To Ikbkg Deficiency

X-Linked Msmd Due To Nemo Deficiency

Invasive Pneumococcal Disease, Recurrent Isolated, 2

Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly

Ipd2, Formerly

Nf-Kappa B Essential Modulator Deficiency

Familial X-Linked 1 Atypical Mycobacteriosis

Nemo Deficiency Syndrome

Amcbx1

Familial, X-Linked, Atypical Mycobacteriosis 1

Ipd2

Recurrent Isolated Invasive Pneumococcal Disease 2

X-Linked Disseminated Atypical Mycobacterial Infection Type 1

X-Linked Immunodeficiency 33, Mycobacteriosis

X-Linked Susceptibility To Mycobacterial Disease Type 1

Invasive Pneumococcal Disease, Recurrent Isolated, Type 2

Atypical Mycobacteriosis, Familial, X-Linked 1
Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15342 UBE2E1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris UBE2E1 VGNC VGNC:52908
Rattus norvegicus UBE2E1 RGD RGD:2324438
Bos taurus UBE2E1 VGNC VGNC:107009
Mus musculus UBE2E1 MGD MGI:107411
Macaca mulatta UBE2E1 VGNC VGNC:78694
Felis catus UBE2E1 VGNC VGNC:102860
Others UBE2E1 NCBI
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