UBE2E1 - ubiquitin conjugating enzyme E2 E1 Gene

中文名称：泛素结合酶 E2 E1

种属: Homo sapiens

同用名: UBCH6

基因 ID: 7324 | 基因类型: protein coding

关于 UBE2E1

Cytogenetic location: 3p24.2 Genomic coordinates (GRCh38): 3:23,805,955-23,891,640 (from NCBI)

This gene has 11 transcripts (splice variants), 148 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 26.5), brain (RPKM 25.3) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。已经为该基因发现了编码不同同种型的三个可变剪接的转录物变体。[RefSeq 提供，2011 年 1 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

UBE2E1 基因产物(3)

mRNA	Protein	Name
NM_001202476.2	NP_001189405.1	ubiquitin-conjugating enzyme E2 E1 isoform 3
NM_003341.5	NP_003332.1	ubiquitin-conjugating enzyme E2 E1 isoform 1
NM_182666.3	NP_872607.1	ubiquitin-conjugating enzyme E2 E1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ISG15 transferase activity	IDA IDA: 通过直接分析推断	16428300	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16307923	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: 通过直接分析推断	15247280	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	16307923	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ISG15-protein conjugation	IDA IDA: 通过直接分析推断	16428300	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16307923	GOA
involved in protein K48-linked ubiquitination	IDA IDA: 通过直接分析推断	20061386	GOA
involved in protein polyubiquitination	IDA IDA: 通过直接分析推断	15247280	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	9990509	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	18845142	GOA
part of ubiquitin ligase complex	IDA IDA: 通过直接分析推断	16307923	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBE2E1 蛋白结构

UQ_con

0
100
193 a.a.

蛋白主名

其他名称

ubiquitin-conjugating enzyme E2 E1

(E3-independent) E2 ubiquitin-conjugating enzyme E1

UBE2E1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UBE2E1	P51965	OTUB1	Homo sapiens	Q96FW1	Y2H	19549727
种属内	UBE2E1	P51965	ZNRF1	Homo sapiens	Q8ND25	Enzymatic Study	19549727
种属内	UBE2E1	P51965	ZNRF1	Homo sapiens	Q8ND25	Y2H Array	19690564
种属内	UBE2E1	P51965	PAF1	Homo sapiens	Q8N7H5	Pull Down	16307923
种属内	UBE2E1	P51965	RNF11	Homo sapiens	Q9Y3C5	Enzymatic Study	19549727
种属内	UBE2E1	P51965	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	19549727

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Limb-Girdle Muscular Dystrophy

Lgmd	Limb Girdle Muscular Dystrophy
Muscular Dystrophies, Limb-Girdle	Erb'S Muscular Dystrophy
Leyden-Mbius Muscular Dystrophy	Limb-Girdle Syndrome
Myopathic Limb-Girdle Syndrome	Limb Girdle
Muscular Dystrophy Limb-Girdle	Dystrophy, Muscular, Limb-Girdle
Lgmd - [Limb-Girdle Muscular Dystrophy]	Limb Girdle Muscle Dystrophy
Limb-Girdle Myopathy

Immunodeficiency 33

IMD33	X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency
X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency	X-Linked Msmd Due To Ikbkg Deficiency
X-Linked Msmd Due To Nemo Deficiency	Invasive Pneumococcal Disease, Recurrent Isolated, 2
Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly	Ipd2, Formerly
Nf-Kappa B Essential Modulator Deficiency	Familial X-Linked 1 Atypical Mycobacteriosis
Nemo Deficiency Syndrome	Amcbx1
Familial, X-Linked, Atypical Mycobacteriosis 1	Ipd2
Recurrent Isolated Invasive Pneumococcal Disease 2	X-Linked Disseminated Atypical Mycobacterial Infection Type 1
X-Linked Immunodeficiency 33, Mycobacteriosis	X-Linked Susceptibility To Mycobacterial Disease Type 1
Invasive Pneumococcal Disease, Recurrent Isolated, Type 2	Atypical Mycobacteriosis, Familial, X-Linked 1

Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1	SCA1
Olivopontocerebellar Atrophy I	Opca1
Opca4	Menzel Type Opca
Schut-Haymaker Type Opca	Spinocerebellar Atrophy I
Opca I	Olivopontocerebellar Atrophy Iv
Opca Iv	Cerebelloparenchymal Disorder I
Cpd1	Olivopontocerebellar Atrophy 1
Cerebelloparenchymal Disorder 1	Olivopontocerebellar Atrophy 4
Spinocerebellar Atrophy 1	Type 1 Spinocerebellar Ataxia
Spinocerebellar Ataxia-1	Ataxia, Spinocerebellar, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15342	UBE2E1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	UBE2E1	VGNC	VGNC:52908
Rattus norvegicus	UBE2E1	RGD	RGD:2324438
Bos taurus	UBE2E1	VGNC	VGNC:107009
Mus musculus	UBE2E1	MGD	MGI:107411
Macaca mulatta	UBE2E1	VGNC	VGNC:78694
Felis catus	UBE2E1	VGNC	VGNC:102860
Others	UBE2E1	NCBI

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