PAF1 - PAF1 homolog, Paf1/RNA polymerase II complex component Gene

中文名称：PAF1 同源物，Paf1/RNA 聚合酶 II 复合物成分

种属: Homo sapiens

同用名: PD2; F23149_1

基因 ID: 54623 | 基因类型: protein coding

关于 PAF1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,385,629-39,391,106 (from NCBI)

This gene has 8 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in testis (RPKM 32.1), ovary (RPKM 17.7) and 25 other tissues.

功能概要

该基因编码聚合酶相关因子 (PAF1) 复合物的一个亚基。 PAF1 复合物与 RNA 聚合酶 II 相互作用，并在转录延伸和组蛋白修饰 (包括泛素化和甲基化) 中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 2 月]

This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

PAF1 基因产物(2)

mRNA	Protein	Name
NM_001256826.2	NP_001243755.1	RNA polymerase II-associated factor 1 homolog isoform 2
NM_019088.4	NP_061961.2	RNA polymerase II-associated factor 1 homolog isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II complex binding	IDA IDA: 通过直接分析推断	15923622	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15923622	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA 3'-end processing	IMP IMP: 通过突变表型推断	21329879	GOA
involved in negative regulation of myeloid cell differentiation	IDA IDA: 通过直接分析推断	20541477	GOA
involved in positive regulation of cell cycle G1/S phase transition	IMP IMP: 通过突变表型推断	15923622	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16307923	GOA
involved in protein localization to nucleus	IMP IMP: 通过突变表型推断	22046413	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	20178742	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cdc73/Paf1 complex	IDA IDA: 通过直接分析推断	16307923	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	22046413	GOA
located in membrane	IDA IDA: 通过直接分析推断	22046413	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PAF1 蛋白结构

Paf1

0
100
200
300
400
500
531 a.a.

蛋白主名

其他名称

RNA polymerase II-associated factor 1 homolog

Paf1, RNA polymerase II associated factor, homolog

PAF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PAF1	Q8N7H5	CTR9	Homo sapiens	Q6PD62	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	CTR9	Homo sapiens	Q6PD62	Anti Tag CoIP	16024656
Intra	PAF1	Q8N7H5	CTR9	Homo sapiens	Q6PD62	Anti Tag CoIP	20178742
Intra	PAF1	Q8N7H5	CTR9	Homo sapiens	Q6PD62	Anti Tag CoIP	19410543
Intra	PAF1	Q8N7H5	RTF1	Homo sapiens	Q92541	Anti Tag CoIP	20178742
Intra	PAF1	Q8N7H5	RTF1	Homo sapiens	Q92541	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	RTF1	Homo sapiens	Q92541	Anti Tag CoIP	19410543
Intra	PAF1	Q8N7H5	LINC-PINT	Homo sapiens	A0A455ZAR2	Confocal	30367041
Intra	PAF1	Q8N7H5	LINC-PINT	Homo sapiens	A0A455ZAR2	Anti Tag CoIP	30367041
Intra	PAF1	Q8N7H5	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	20178742
Intra	PAF1	Q8N7H5	POLR2A	Homo sapiens	P24928	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	UBE2E1	Homo sapiens	P51965	Anti Bait CoIP	16307923
Intra	PAF1	Q8N7H5	HSPB1	Homo sapiens	P04792	Anti Bait CoIP	25277244
Intra	PAF1	Q8N7H5	HSPB1	Homo sapiens	P04792	Reverse RRS	25277244
Intra	PAF1	Q8N7H5	KMT2A	Homo sapiens	Q03164	Anti Bait CoIP	20541477
Intra	PAF1	Q8N7H5	SKIC3	Homo sapiens	Q6PGP7	Anti Tag CoIP	16024656
Intra	PAF1	Q8N7H5	SKIC3	Homo sapiens	Q6PGP7	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	FXR2	Homo sapiens	P51116	Validated Y2H	25416956
Intra	PAF1	Q8N7H5	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	25416956
Intra	PAF1	Q8N7H5	FXR2	Homo sapiens	P51116	Y2H	21516116
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Pull Down	15923622
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	16024656
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	19410543
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Anti Bait CoIP	15923622
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	20178742
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Anti Tag CoIP	16024656
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Y2H Prey Pooling	25416956
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	TAP	24981860
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Anti Tag CoIP	20178742
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Validated Y2H	25416956
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Y2H Prey Pooling	32296183
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Anti Tag CoIP	19410543
Cross	PAF1	Q8N7H5	NS1	Influenza A virus	B2BUF1	Anti Bait CoIP	22419161
Cross	PAF1	Q8N7H5	NS1	Influenza A virus	B2BUF1	Anti Tag CoIP	22419161

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Diamond-Blackfan Anemia 3

DBA3	Anemia, Diamond-Blackfan, 3
Rps24-Related Diamond-Blackfan Anemia	Anemia Diamond-Blackfan 3
Anemia, Diamond-Blackfan, Type 3

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Otopalatodigital Syndrome, Type Ii

Otopalatodigital Syndrome Type 2	Faciopalatoosseous Syndrome
OPD2	Opd Ii Syndrome
Opd Syndrome 2	Cranioorodigital Syndrome
Fpo	Oto-Palato-Digital Syndrome, Type Ii
Andre Syndrome	Oto-Palato-Digital Syndrome Type 2
Otopalatodigital Syndrome Type Ii	Cranio-Oro-Digital Syndrome
Opd 2 Syndrome	Opd Syndrome, Type 2
Taybi Syndrome	Otopalatodigital Syndrome 2
Oto-Palato-Digital Syndrome, Type 2	Oto-Palato-Digital Syndrome Type 1

Retinitis Pigmentosa 40

RP40	Retinitis Pigmentosa-40
Retinitis Pigmentosa, Type 40

Malignant Fibrous Histiocytoma Of Bone

Malignant Fibrous Histiocytoma Of The Bone

Myopathy, Distal, 4

Distal Myopathy With Posterior Leg And Anterior Hand Involvement	MPD4
Williams Distal Myopathy	Distal Muscular Dystrophy 4
Distal Abd-Filaminopathy	Distal Myopathy 4
Myopathy, Distal, Type 4

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-160267	iPAF1C	Inhibitor	99.08%	否
HY-P3103A	PINT-87aa TFA		≥99.0%	否
HY-130345S	C18-PAF-d4		/	否
HY-N2247A	(+)-Guaiacin		/	否
HY-P3103	PINT-87aa		/	否
HY-RS09966	PAF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-106062	CV 3988		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PAF1	RGD	RGD:1306219
Mus musculus	PAF1	MGD	MGI:1923988
Felis catus	PAF1	VGNC	VGNC:64024
Bos taurus	PAF1	VGNC	VGNC:96701
Macaca mulatta	PAF1	VGNC	VGNC:81492
Others	PAF1	NCBI

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