RTF1 - RTF1 homolog, Paf1/RNA polymerase II complex component Gene

中文名称：RTF1 同源物，Paf1/RNA 聚合酶 II 复合物成分

种属: Homo sapiens

同用名: GTL7; KIAA0252

基因 ID: 23168 | 基因类型: protein coding

关于 RTF1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,417,095-41,483,563 (from NCBI)

This gene has 7 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 16.0), testis (RPKM 15.7) and 25 other tissues.

功能概要

根据对其他生物体中类似蛋白质的研究，该基因座可能代表参与调节转录延伸和染色质重塑的基因。编码的蛋白质可以结合单链 DNA。[RefSeq 提供，2010 年 9 月]

This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in Other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010]

RTF1 基因产物(1)

mRNA	Protein	Name
NM_015138.5	NP_055953.3	RNA polymerase-associated protein RTF1 homolog

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15923622	GOA
enables single-stranded DNA binding	IDA IDA: 通过直接分析推断	18184592	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in stem cell population maintenance	IDA IDA: 通过直接分析推断	19345177	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	20178742	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cdc73/Paf1 complex	IDA IDA: 通过直接分析推断	20178742	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RTF1 蛋白结构

Plus-3

0
200
400
600
710 a.a.

蛋白主名

其他名称

RNA polymerase-associated protein RTF1 homolog

Rtf1, Paf1/RNA polymerase II complex component, homolog

RTF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RTF1	Q92541	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	20178742
种属内	RTF1	Q92541	PAF1	Homo sapiens	Q8N7H5	TAP	24981860
种属内	RTF1	Q92541	PAF1	Homo sapiens	Q8N7H5	Anti Bait CoIP	16024656
种属内	RTF1	Q92541	CDC73	Homo sapiens	Q6P1J9	Anti Bait CoIP	16024656
种属内	RTF1	Q92541	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	20178742

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Immunodeficiency 47

Congenital Disorder Of Glycosylation Type Ii	CDG2E
Congenital Disorder Of Glycosylation Type Iie	IMD47
Cdg2s	Cdg Iis
Cdgiis	Immunodeficiency And Hepatopathy With Or Without Neurologic Features
Congenital Disorder Of Glycosylation, Type Ii	CDG1I
Congenital Disorder Of Glycosylation, Type Iie	Cdg Iie
Congenital Disorder Of Glycosylation Type 2e	Congenital Disorder Of Glycosylation, Type Iis
Cdg Ii	Cdgii
Cdgiie	Carbohydrate Deficient Glycoprotein Syndrome Type Iie
Cdg Syndrome Type Iie	Congenital Disorder Of Glycosylation Ii
Congenital Disorder Of Glycosylation 1i	Cdg-Iie
Alg2-Cdg	Cdg-Ii
Glycosylation, Congenital Disorder Of, Type Ii	Cdgiide
Congenital Disorder Of Glycosylation Type Iis	Cog7-Cdg
Cdg Syndrome Type Ii	Carbohydrate Deficient Glycoprotein Syndrome Type Ii
Congenital Disorder Of Glycosylation Type 1i	Mannosyltransferase 2 Deficiency
Congenital Disorder Of Glycosylation 2e	Congenital Disorder Of Glycosylation 2s
Congenital Disorders Of Glycosylation Type Ii	Glycosylation, Congenital Disorder Of, Type Iie
Immunodeficiency, Type 47	Congenital Disorder Of Glycosylation Type 2a

Cholestasis, Intrahepatic, Of Pregnancy, 1

ICP1	Intrahepatic Cholestasis Of Pregnancy 1
Cholestasis, Pregnancy-Related, 1	Pregnancy Related Cholestasis 1
Cholestasis Of Pregnancy, Intrahepatic 1	Obstetric Cholestasis
Pregnancy-Related Cholestasis	Recurrent Intrahepatic Cholestasis Of Pregnancy
Cholestasis, Intrahepatic, Of Pregnancy, Type 1	Cholestasis Of Pregnancy

Hereditary Wilms' Tumor

Hereditary Wilms Tumor	Hereditary Wilms Tumour
Hereditary Wilms' Tumour	Wt1

Malignant Fibrous Histiocytoma Of Bone

Malignant Fibrous Histiocytoma Of The Bone

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12318	RTF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RTF1	VGNC	VGNC:45787
Bos taurus	RTF1	VGNC	VGNC:34195
Felis catus	RTF1	VGNC	VGNC:64806
Mus musculus	RTF1	MGD	MGI:1309480
Macaca mulatta	RTF1	VGNC	VGNC:77119
Rattus norvegicus	RTF1	RGD	RGD:1310654

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RTF1 - RTF1 homolog, Paf1/RNA polymerase II complex component Gene

关于 RTF1

功能概要

RTF1 基因产物(1)

RTF1 蛋白结构

RTF1 蛋白互作信息

关联疾病

直系同源

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RTF1 - RTF1 homolog, Paf1/RNA polymerase II complex component Gene

关于 RTF1

功能概要

RTF1 基因产物(1)

RTF1 蛋白结构

RTF1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

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Q

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T

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