CTR9 - CTR9 homolog, Paf1/RNA polymerase II complex component Gene

中文名称：CTR9 同源物，Paf1/RNA 聚合酶 II 复合物成分

种属: Homo sapiens

同用名: TSBP; p150; SH2BP1; p150TSP

基因 ID: 9646 | 基因类型: protein coding

关于 CTR9

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:10,751,246-10,779,746 (from NCBI)

This gene has 6 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 19.1), thyroid (RPKM 14.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是 PAF1 复合物的一个组成部分，它与 RNA 聚合酶 II 结合并在转录调节和延伸中发挥作用。该复合物还在组蛋白修饰中发挥作用。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene is a component of the PAF1 complex, which associates with RNA polymerase II and functions in transcriptional regulation and elongation. This complex also plays a role in the modification of histones. [provided by RefSeq, Oct 2016]

CTR9 基因产物(2)

mRNA	Protein	Name
NM_001346279.2	NP_001333208.1	RNA polymerase-associated protein CTR9 homolog isoform 2
NM_014633.5	NP_055448.1	RNA polymerase-associated protein CTR9 homolog isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15923622	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of myeloid cell differentiation	IDA IDA: 通过直接分析推断	20541477	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16307923	GOA
involved in stem cell population maintenance	IDA IDA: 通过直接分析推断	19345177	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	20178742	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cdc73/Paf1 complex	IDA IDA: 通过直接分析推断	16307923	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CTR9 蛋白结构

TPR_11

TPR_2

TPR_1

TPR_11

TPR_1

0
200
400
600
800
1000
1173 a.a.

蛋白主名

其他名称

RNA polymerase-associated protein CTR9 homolog

Ctr9, Paf1/RNA polymerase II complex component, homolog

CTR9 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CTR9	Q6PD62	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	20178742
Intra	CTR9	Q6PD62	PAF1	Homo sapiens	Q8N7H5	TAP	24981860
Intra	CTR9	Q6PD62	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	26496610
Intra	CTR9	Q6PD62	SKIC8	Homo sapiens	Q9GZS3	Anti Tag CoIP	26496610
Intra	CTR9	Q6PD62	SKIC8	Homo sapiens	Q9GZS3	Anti Tag CoIP	20178742
Intra	CTR9	Q6PD62	SKIC8	Homo sapiens	Q9GZS3	GMS	20178742
Intra	CTR9	Q6PD62	SKIC8	Homo sapiens	Q9GZS3	TAP	24981860
Intra	CTR9	Q6PD62	KMT2A	Homo sapiens	Q03164	Anti Tag CoIP	20541477
Intra	CTR9	Q6PD62	CDC73	Homo sapiens	Q6P1J9	TAP	24981860
Intra	CTR9	Q6PD62	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	26496610
Intra	CTR9	Q6PD62	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	20178742

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hereditary Wilms' Tumor

Hereditary Wilms Tumor	Hereditary Wilms Tumour
Hereditary Wilms' Tumour	Wt1

Malignant Fibrous Histiocytoma Of Bone

Malignant Fibrous Histiocytoma Of The Bone

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03316	CTR9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CTR9	VGNC	VGNC:61262
Rattus norvegicus	CTR9	RGD	RGD:1311097
Canis familiaris	CTR9	VGNC	VGNC:39706
Bos taurus	CTR9	VGNC	VGNC:27810
Mus musculus	CTR9	MGD	MGI:109345
Macaca mulatta	CTR9	VGNC	VGNC:71424

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