1. Gene
  2. RNF11 - ring finger protein 11 Gene

RNF11 - ring finger protein 11 Gene

中文名称:无名指蛋白 11

种属: Homo sapiens

同用名: CGI-123; SID1669

基因 ID: 26994 | 基因类型: protein coding

关于 RNF11

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:51,236,273-51,273,447 (from NCBI)

This gene has 3 transcripts (splice variants), 260 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 65.4), thyroid (RPKM 55.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质包含一个 RING-H2 指基序,已知它对蛋白质-蛋白质相互作用很重要。该基因的表达已被证明是由突变的 RET 蛋白 (MEN2A/MEN2B) 诱导的。已知 RET 基因中的种系突变与多发性内分泌肿瘤 (MEN) 的发展有关。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]

RNF11 基因产物(1)

mRNA Protein Name
NM_014372.5 NP_055187.1 RING finger protein 11
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14755250 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
24105792 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
24105792 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
14755250 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ubiquitin ligase complex IDA
IDA: 通过直接分析推断
14755250 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RNF11 蛋白结构

zf-RING_2

zf-RING_2: Ring finger domain (98 - 139)

  • 0
  • 100
  • 154 a.a.
蛋白主名 其他名称

RING finger protein 11

RNF11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RNF11 Q9Y3C5 ADAMTSL4 Homo sapiens Q6UY14-3 32814053
种属内
RNF11 Q9Y3C5 ADAMTSL4 Homo sapiens Q6UY14-3 32814053
种属内
RNF11 Q9Y3C5 ADAMTSL4 Homo sapiens Q6UY14-3 32814053
种属内
RNF11 Q9Y3C5 IQUB Homo sapiens Q8NA54 32814053
种属内
RNF11 Q9Y3C5 IQUB Homo sapiens Q8NA54 32814053
种属内
RNF11 Q9Y3C5 IQUB Homo sapiens Q8NA54 32814053
种属内
RNF11 Q9Y3C5 ATG10 Homo sapiens Q9H0Y0 32814053
种属内
RNF11 Q9Y3C5 ATG10 Homo sapiens Q9H0Y0 32814053
种属内
RNF11 Q9Y3C5 ATG10 Homo sapiens Q9H0Y0 32814053
种属内
RNF11 Q9Y3C5 UBE2V1 Homo sapiens Q13404 19549727
种属内
RNF11 Q9Y3C5 UBE2N Homo sapiens P61088 19549727
种属内
RNF11 Q9Y3C5 UBE2N Homo sapiens P61088 19549727
种属内
RNF11 Q9Y3C5 USP2 Homo sapiens O75604-3 32814053
种属内
RNF11 Q9Y3C5 USP2 Homo sapiens O75604-3 32814053
种属内
RNF11 Q9Y3C5 USP2 Homo sapiens O75604-3 32814053
种属内
RNF11 Q9Y3C5 WWOX Homo sapiens Q9NZC7-5 32814053
种属内
RNF11 Q9Y3C5 WWOX Homo sapiens Q9NZC7-5 32814053
种属内
RNF11 Q9Y3C5 WWOX Homo sapiens Q9NZC7-5 32814053
种属内
RNF11 Q9Y3C5 CLIP3 Homo sapiens Q96DZ5 32814053
种属内
RNF11 Q9Y3C5 CLIP3 Homo sapiens Q96DZ5 32814053
种属内
RNF11 Q9Y3C5 CLIP3 Homo sapiens Q96DZ5 32814053
种属内
RNF11 Q9Y3C5 PLEKHG7 Homo sapiens Q6ZR37 32814053
种属内
RNF11 Q9Y3C5 ITCH Homo sapiens Q96J02 20676133
种属内
RNF11 Q9Y3C5 IL16 Homo sapiens Q14005-2 32814053
种属内
RNF11 Q9Y3C5 IL16 Homo sapiens Q14005-2 32814053
种属内
RNF11 Q9Y3C5 IL16 Homo sapiens Q14005-2 32814053
种属内
RNF11 Q9Y3C5 TRIM35 Homo sapiens Q9UPQ4-2 32814053
种属内
RNF11 Q9Y3C5 TRIM35 Homo sapiens Q9UPQ4-2 32814053
种属内
RNF11 Q9Y3C5 TRIM35 Homo sapiens Q9UPQ4-2 32814053
种属内
RNF11 Q9Y3C5 TCEAL8 Homo sapiens Q8IYN2 32814053
种属内
RNF11 Q9Y3C5 TCEAL8 Homo sapiens Q8IYN2 32814053
种属内
RNF11 Q9Y3C5 TCEAL8 Homo sapiens Q8IYN2 32814053
种属内
RNF11 Q9Y3C5 RNF14 Homo sapiens Q9UBS8 32814053
种属内
RNF11 Q9Y3C5 RNF14 Homo sapiens Q9UBS8 32814053
种属内
RNF11 Q9Y3C5 RNF14 Homo sapiens Q9UBS8 32814053
种属内
RNF11 Q9Y3C5 MPND Homo sapiens Q8N594 32814053
种属内
RNF11 Q9Y3C5 MPND Homo sapiens Q8N594 32814053
种属内
RNF11 Q9Y3C5 MPND Homo sapiens Q8N594 32814053
种属内
RNF11 Q9Y3C5 ANXA8 Homo sapiens P13928 32814053
种属内
RNF11 Q9Y3C5 ANXA8 Homo sapiens P13928 32814053
种属内
RNF11 Q9Y3C5 ANXA8 Homo sapiens P13928 32814053
种属内
RNF11 Q9Y3C5 OTUD7B Homo sapiens Q6GQQ9-2 32814053
种属内
RNF11 Q9Y3C5 OTUD7B Homo sapiens Q6GQQ9-2 32814053
种属内
RNF11 Q9Y3C5 OTUD7B Homo sapiens Q6GQQ9-2 32814053
种属内
RNF11 Q9Y3C5 TMEM61 Homo sapiens Q8N0U2 32814053
种属内
RNF11 Q9Y3C5 TMEM61 Homo sapiens Q8N0U2 32814053
种属内
RNF11 Q9Y3C5 TMEM61 Homo sapiens Q8N0U2 32814053
种属内
RNF11 Q9Y3C5 TMUB2 Homo sapiens Q71RG4-4 32814053
种属内
RNF11 Q9Y3C5 TMUB2 Homo sapiens Q71RG4-4 32814053
种属内
RNF11 Q9Y3C5 TMUB2 Homo sapiens Q71RG4-4 32814053
种属内
RNF11 Q9Y3C5 CNST Homo sapiens Q6PJW8-3 32814053
种属内
RNF11 Q9Y3C5 CNST Homo sapiens Q6PJW8-3 32814053
种属内
RNF11 Q9Y3C5 CNST Homo sapiens Q6PJW8-3 32814053
种属内
RNF11 Q9Y3C5 DKFZp547K2416 Homo sapiens Q8NDP9 32814053
种属内
RNF11 Q9Y3C5 DKFZp547K2416 Homo sapiens Q8NDP9 32814053
种属内
RNF11 Q9Y3C5 DKFZp547K2416 Homo sapiens Q8NDP9 32814053
种属内
RNF11 Q9Y3C5 ARNT2 Homo sapiens Q86TN1 32814053
种属内
RNF11 Q9Y3C5 ARNT2 Homo sapiens Q86TN1 32814053
种属内
RNF11 Q9Y3C5 ARNT2 Homo sapiens Q86TN1 32814053
种属内
RNF11 Q9Y3C5 CAMKK1 Homo sapiens Q8N5S9-2 32814053
种属内
RNF11 Q9Y3C5 CAMKK1 Homo sapiens Q8N5S9-2 32814053
种属内
RNF11 Q9Y3C5 CAMKK1 Homo sapiens Q8N5S9-2 32814053
种属内
RNF11 Q9Y3C5 KLF15 Homo sapiens Q9UIH9 32814053
种属内
RNF11 Q9Y3C5 KLF15 Homo sapiens Q9UIH9 32814053
种属内
RNF11 Q9Y3C5 KLF15 Homo sapiens Q9UIH9 32814053
种属内
RNF11 Q9Y3C5 HK3 Homo sapiens P52790 32814053
种属内
RNF11 Q9Y3C5 HK3 Homo sapiens P52790 32814053
种属内
RNF11 Q9Y3C5 HK3 Homo sapiens P52790 32814053
种属内
RNF11 Q9Y3C5 QARS1 Homo sapiens P47897
Y2H
15231748
种属内
RNF11 Q9Y3C5 UBE2D2 Homo sapiens P62837 19549727
种属内
RNF11 Q9Y3C5 UBE2D2 Homo sapiens P62837
Y2H
15231748
种属内
RNF11 Q9Y3C5 UBE2D2 Homo sapiens P62837 19690564
种属内
RNF11 Q9Y3C5 UBE2D2 Homo sapiens P62837
Y2H
19549727
种属内
RNF11 Q9Y3C5 UBE2D3 Homo sapiens P61077 19690564
种属内
RNF11 Q9Y3C5 TDG Homo sapiens Q13569 32814053
种属内
RNF11 Q9Y3C5 TDG Homo sapiens Q13569 32814053
种属内
RNF11 Q9Y3C5 TDG Homo sapiens Q13569 32814053
种属内
RNF11 Q9Y3C5 UBE2E3 Homo sapiens Q969T4 19549727
种属内
RNF11 Q9Y3C5 UBA52 Homo sapiens P62987 32814053
种属内
RNF11 Q9Y3C5 UBA52 Homo sapiens P62987
Y2H
15231748
种属内
RNF11 Q9Y3C5 UBA52 Homo sapiens P62987 32814053
种属内
RNF11 Q9Y3C5 UBA52 Homo sapiens P62987 32814053
种属内
RNF11 Q9Y3C5 RPS27A Homo sapiens P62979
Y2H
14755250
种属内
RNF11 Q9Y3C5 PSMB8 Homo sapiens P28062-2 32814053
种属内
RNF11 Q9Y3C5 PSMB8 Homo sapiens P28062-2 32814053
种属内
RNF11 Q9Y3C5 PSMB8 Homo sapiens P28062-2 32814053
种属内
RNF11 Q9Y3C5 SMURF2 Homo sapiens Q9HAU4 14755250
种属内
RNF11 Q9Y3C5 SMURF2 Homo sapiens Q9HAU4 20676133
种属内
RNF11 Q9Y3C5 UBB Homo sapiens P0CG47 28514442
种属内
RNF11 Q9Y3C5 UBB Homo sapiens P0CG47 33961781
种属内
RNF11 Q9Y3C5 UBB Homo sapiens P0CG47
Y2H
14755250
种属内
RNF11 Q9Y3C5 GGA1 Homo sapiens Q9UJY5 20676133
种属内
RNF11 Q9Y3C5 BAK1 Homo sapiens Q16611 32814053
种属内
RNF11 Q9Y3C5 BAK1 Homo sapiens Q16611 32814053
种属内
RNF11 Q9Y3C5 BAK1 Homo sapiens Q16611 32814053
种属内
RNF11 Q9Y3C5 TNFAIP3 Homo sapiens P21580 19131965
种属内
RNF11 Q9Y3C5 LPIN1 Homo sapiens Q14693 32814053
种属内
RNF11 Q9Y3C5 LPIN1 Homo sapiens Q14693 32814053
种属内
RNF11 Q9Y3C5 LPIN1 Homo sapiens Q14693 32814053
种属内
RNF11 Q9Y3C5 TAX1BP1 Homo sapiens Q86VP1 19131965
种属内
RNF11 Q9Y3C5 TAX1BP1 Homo sapiens Q86VP1
Y2H
15231748
种属内
RNF11 Q9Y3C5 ASB13 Homo sapiens Q8WXK3 32814053
种属内
RNF11 Q9Y3C5 ASB13 Homo sapiens Q8WXK3 32814053
种属内
RNF11 Q9Y3C5 ASB13 Homo sapiens Q8WXK3 32814053
种属内
RNF11 Q9Y3C5 KLHL20 Homo sapiens Q9Y2M5 32814053
种属内
RNF11 Q9Y3C5 KLHL20 Homo sapiens Q9Y2M5 32814053
种属内
RNF11 Q9Y3C5 KLHL20 Homo sapiens Q9Y2M5 32814053
种属内
RNF11 Q9Y3C5 NGEF Homo sapiens Q8N5V2 32814053
种属内
RNF11 Q9Y3C5 NGEF Homo sapiens Q8N5V2 32814053
种属内
RNF11 Q9Y3C5 NGEF Homo sapiens Q8N5V2 32814053
种属内
RNF11 Q9Y3C5 NEDD4 Homo sapiens P46934 20676133
种属内
RNF11 Q9Y3C5 NEDD4 Homo sapiens P46934
Y2H
15231748
种属内
RNF11 Q9Y3C5 LNX1 Homo sapiens Q8TBB1 32814053
种属内
RNF11 Q9Y3C5 LNX1 Homo sapiens Q8TBB1 32814053
种属内
RNF11 Q9Y3C5 LNX1 Homo sapiens Q8TBB1 32814053
种属内
RNF11 Q9Y3C5 UBE2D1 Homo sapiens P51668 19690564
种属内
RNF11 Q9Y3C5 WWP2 Homo sapiens O00308 32814053
种属内
RNF11 Q9Y3C5 WWP2 Homo sapiens O00308 32814053
种属内
RNF11 Q9Y3C5 WWP2 Homo sapiens O00308 32814053
种属内
RNF11 Q9Y3C5 ILF3 Homo sapiens Q9NXX0 32814053
种属内
RNF11 Q9Y3C5 ILF3 Homo sapiens Q9NXX0 32814053
种属内
RNF11 Q9Y3C5 ILF3 Homo sapiens Q9NXX0 32814053
种属内
RNF11 Q9Y3C5 FOSL1 Homo sapiens P15407 32814053
种属内
RNF11 Q9Y3C5 FOSL1 Homo sapiens P15407 32814053
种属内
RNF11 Q9Y3C5 FOSL1 Homo sapiens P15407 32814053
种属内
RNF11 Q9Y3C5 UBE2D4 Homo sapiens Q9Y2X8
Y2H
15231748
种属内
RNF11 Q9Y3C5 UBE2D4 Homo sapiens Q9Y2X8 19549727
种属内
RNF11 Q9Y3C5 UBE2D4 Homo sapiens Q9Y2X8
Y2H
21516116
种属内
RNF11 Q9Y3C5 UBE2D4 Homo sapiens Q9Y2X8 19690564
种属内
RNF11 Q9Y3C5 TASOR2 Homo sapiens Q5VWN6 32814053
种属内
RNF11 Q9Y3C5 TASOR2 Homo sapiens Q5VWN6 32814053
种属内
RNF11 Q9Y3C5 TASOR2 Homo sapiens Q5VWN6 32814053
种属内
RNF11 Q9Y3C5 RAI2 Homo sapiens Q9Y5P3 32814053
种属内
RNF11 Q9Y3C5 RAI2 Homo sapiens Q9Y5P3 32814053
种属内
RNF11 Q9Y3C5 RAI2 Homo sapiens Q9Y5P3 32814053
种属内
RNF11 Q9Y3C5 LOXL4 Homo sapiens Q96JB6 32814053
种属内
RNF11 Q9Y3C5 LOXL4 Homo sapiens Q96JB6 32814053
种属内
RNF11 Q9Y3C5 LOXL4 Homo sapiens Q96JB6 32814053
种属内
RNF11 Q9Y3C5 SPPL2B Homo sapiens Q8TCT7-2 32814053
种属内
RNF11 Q9Y3C5 SPPL2B Homo sapiens Q8TCT7-2 32814053
种属内
RNF11 Q9Y3C5 SPPL2B Homo sapiens Q8TCT7-2 32814053
种属内
RNF11 Q9Y3C5 METTL27 Homo sapiens Q8N6F8 32814053
种属内
RNF11 Q9Y3C5 METTL27 Homo sapiens Q8N6F8 32814053
种属内
RNF11 Q9Y3C5 METTL27 Homo sapiens Q8N6F8 32814053
种属内
RNF11 Q9Y3C5 ZNF57 Homo sapiens Q68EA5 32814053
种属内
RNF11 Q9Y3C5 ZNF57 Homo sapiens Q68EA5 32814053
种属内
RNF11 Q9Y3C5 ZNF57 Homo sapiens Q68EA5 32814053
种属内
RNF11 Q9Y3C5 SEMA4G Homo sapiens Q9NTN9-3 32814053
种属内
RNF11 Q9Y3C5 SEMA4G Homo sapiens Q9NTN9-3 32814053
种属内
RNF11 Q9Y3C5 SEMA4G Homo sapiens Q9NTN9-3 32814053
种属内
RNF11 Q9Y3C5 RNF168 Homo sapiens Q8IYW5 32814053
种属内
RNF11 Q9Y3C5 RNF168 Homo sapiens Q8IYW5 32814053
种属内
RNF11 Q9Y3C5 RNF168 Homo sapiens Q8IYW5 32814053
种属内
RNF11 Q9Y3C5 UBQLN2 Homo sapiens Q9UHD9 32814053
种属内
RNF11 Q9Y3C5 UBQLN2 Homo sapiens Q9UHD9
Y2H
15231748
种属内
RNF11 Q9Y3C5 UBQLN2 Homo sapiens Q9UHD9 32814053
种属内
RNF11 Q9Y3C5 UBQLN2 Homo sapiens Q9UHD9 32814053
种属内
RNF11 Q9Y3C5 BECN1 Homo sapiens Q14457 32814053
种属内
RNF11 Q9Y3C5 BECN1 Homo sapiens Q14457 32814053
种属内
RNF11 Q9Y3C5 BECN1 Homo sapiens Q14457 32814053
种属内
RNF11 Q9Y3C5 SMURF1 Homo sapiens Q9HCE7-2 32814053
种属内
RNF11 Q9Y3C5 SMURF1 Homo sapiens Q9HCE7-2 32814053
种属内
RNF11 Q9Y3C5 SMURF1 Homo sapiens Q9HCE7-2 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus RNF11 VGNC VGNC:34009
Macaca mulatta RNF11 VGNC VGNC:76703
Felis catus RNF11 VGNC VGNC:80342
Mus musculus RNF11 MGD MGI:1352759
Rattus norvegicus RNF11 RGD RGD:2321596
Canis familiaris RNF11 VGNC VGNC:45620
Others RNF11 NCBI