1. Gene
  2. NEDD4 - NEDD4 E3 ubiquitin protein ligase Gene

NEDD4 - NEDD4 E3 ubiquitin protein ligase Gene

中文名称:NEDD4 E3 泛素蛋白连接酶

种属: Homo sapiens

同用名: RPF1; NEDD4-1

基因 ID: 4734 | 基因类型: protein coding

关于 NEDD4

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:55,826,917-55,993,612 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 24 paralogues. Ubiquitous expression in placenta (RPKM 6.4), liver (RPKM 5.9) and 23 other tissues.

功能概要

该基因是 HECT 泛素连接酶 NEDD4 家族的创始成员,其在蛋白质降解的泛素蛋白酶体系统中起作用。编码的蛋白质包含一个 N 端钙和磷脂结合 C2 结构域,后跟多个富含色氨酸的 WW 结构域和一个 C 端 HECT 泛素连接酶催化结构域。它在许多膜受体、内吞机制组件和肿瘤抑制因子 PTEN 的调节中起着关键作用。[RefSeq 提供,2016 年 7 月]

This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin Proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin Ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

NEDD4 基因产物(6)

mRNA Protein Name
NM_001284338.2 NP_001271267.1 E3 ubiquitin-protein ligase NEDD4 isoform 3
NM_001284339.1 NP_001271268.1 E3 ubiquitin-protein ligase NEDD4 isoform 4
NM_001284340.1 NP_001271269.1 E3 ubiquitin-protein ligase NEDD4 isoform 5
NM_001329212.2 NP_001316141.1 E3 ubiquitin-protein ligase NEDD4 isoform 6
NM_006154.4 NP_006145.2 E3 ubiquitin-protein ligase NEDD4 isoform 1
NM_198400.3 NP_940682.2 E3 ubiquitin-protein ligase NEDD4 isoform 2

NEDD4 蛋白结构

WW

WW: WW domain (612 - 641)

WW

WW: WW domain (769 - 798)

WW

WW: WW domain (842 - 871)

WW

WW: WW domain (894 - 923)

HECT

HECT: HECT-domain (ubiquitin-transferase) (1014 - 1316)

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  • 1319 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase NEDD4

HECT-type E3 ubiquitin transferase NEDD4

NEDD4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NEDD4 P46934 FGFR1 Homo sapiens P11362 21765395
种属内
NEDD4 P46934 FGFR1 Homo sapiens P11362 21765395
种属内
NEDD4 P46934 FGFR1 Homo sapiens P11362
FPS
21765395
种属内
NEDD4 P46934 MLANA Homo sapiens Q16655 37219487
种属内
NEDD4 P46934 SCNN1B Homo sapiens P51168
FPS
39009827
种属内
NEDD4 P46934 SCNN1B Homo sapiens P51168 21765395
种属内
NEDD4 P46934 SCNN1B Homo sapiens P51168 21765395
种属内
NEDD4 P46934 SCNN1B Homo sapiens P51168 11359767
种属内
NEDD4 P46934 SCNN1B Homo sapiens P51168 39009827
种属内
NEDD4 P46934 SCNN1B Homo sapiens P51168
FPS
21765395
种属内
NEDD4 P46934 PIP4P2 Homo sapiens Q8N4L2 37219487
种属内
NEDD4 P46934 UVRAG Homo sapiens Q9P2Y5 37219487
种属内
NEDD4 P46934 UVRAG Homo sapiens Q9P2Y5 35044719
种属内
NEDD4 P46934 MS4A10 Homo sapiens Q96PG2 35044719
种属内
NEDD4 P46934 TRERF1 Homo sapiens Q96PN7 37219487
种属内
NEDD4 P46934 TRERF1 Homo sapiens Q96PN7 35044719
种属内
NEDD4 P46934 YWHAE Homo sapiens P62258
TAP
24981860
种属内
NEDD4 P46934 YWHAE Homo sapiens P62258 36931259
种属内
NEDD4 P46934 MAP1LC3B Homo sapiens Q9GZQ8 20562859
种属内
NEDD4 P46934 TP73 Homo sapiens O15350 37219487
种属内
NEDD4 P46934 TP73 Homo sapiens O15350 35044719
种属内
NEDD4 P46934 PRRG4 Homo sapiens Q9BZD6 37219487
种属内
NEDD4 P46934 PRRG4 Homo sapiens Q9BZD6 35044719
种属内
NEDD4 P46934 PRR7 Homo sapiens Q8TB68 33961781
种属内
NEDD4 P46934 PRR7 Homo sapiens Q8TB68 35044719
种属内
NEDD4 P46934 RNF11 Homo sapiens Q9Y3C5 35044719
种属内
NEDD4 P46934 RNF11 Homo sapiens Q9Y3C5
FPS
37100772
种属内
NEDD4 P46934 UBB Homo sapiens P0CG47
TAP
24981860
种属内
NEDD4 P46934 PTEN Homo sapiens P60484 19345329
种属内
NEDD4 P46934 PTEN Homo sapiens P60484 19345329
种属内
NEDD4 P46934 GABARAP Homo sapiens O95166 20562859
种属内
NEDD4 P46934 GABARAPL2 Homo sapiens P60520 20562859
种属内
NEDD4 P46934 LITAF Homo sapiens Q99732
IF
16118794
种属内
NEDD4 P46934 LITAF Homo sapiens Q99732 16118794
种属内
NEDD4 P46934 TMEM51 Homo sapiens Q9NW97 37219487
种属内
NEDD4 P46934 GABARAPL1 Homo sapiens Q9H0R8 20562859
种属内
NEDD4 P46934 SCNN1A Homo sapiens P37088 11359767
种属内
NEDD4 P46934 SCNN1A Homo sapiens P37088 11359767
种属内
NEDD4 P46934 SCNN1A Homo sapiens P37088
NMR
23665454
种属内
NEDD4 P46934 ENTREP1 Homo sapiens Q15884 35044719
种属内
NEDD4 P46934 LDLRAD4 Homo sapiens O15165 35044719
种属间
NEDD4 P46934 UL56 Human herpesvirus 2 P28282
FPS
37100772
种属间
NEDD4 P46934 VP40 Sudan ebolavirus Q5XX06
FPS
37100772
种属间
NEDD4 P46934 VP40 Sudan ebolavirus Q5XX06 37100772
种属间: 跨种属相互作用 种属内: 同种属相互作用

NEDD4 抗体

目录号 产品名 应用 反应物种
HY-P82765 NEDD4 Antibody (YA2510) WB, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Liddle Syndrome 1

Liddle Syndrome

Pseudoaldosteronism

Liddle'S Syndrome

LIDLS1

Lidls

Pseudohyperaldosteronism

Pseudoprimary Hyperaldosteronism

Pseudohyperaldosteronism Type 1

Liddles Syndrome

Pseudohypoaldosteronism
Keloid Formation

KLDF

Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome

Pten Hamartoma Tumor Syndrome

Lhermitte-Duclos Disease

Bannayan-Zonana Syndrome

Phts

Riley-Smith Syndrome

Bzs

Ruvalcaba-Myhre-Smith Syndrome

Multiple Hamartoma Syndrome

Rmss

Brrs

Dysplastic Gangliocytoma Of The Cerebellum

CWS1

Cs

Cd

Mham

Pten Hamartoma Tumor Syndrome With Granular Cell Tumor

Macrocephaly Multiple Lipomas And Hemangiomata

Bannayan-Ruvalcaba-Riley Syndrome

Myhre-Riley-Smith Syndrome

LDD

Cerebelloparenchymal Disorder Vi

Hamartoma Syndrome, Multiple

Bbrs

Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata

Macrocephaly, Multiple Lipomas, And Hemangiomata

Macrocephaly Pseudopapilledema And Multiple Hemangiomas

Ruvalcaba -Myhre-Smith Syndrome

Ruvalcaba-Myhre Syndrome

Cowden Disease

Macrocephaly Pseudopapilledema And Multiple Hemangiomata

Cerebellar Granule Cell Hypertrophy And Megalencephaly

Cpd6

Pten Hamartoma Tumor Syndromes

Cowden Syndrome, Type 1

Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies

Spinocerebellar Ataxia 31

Spinocerebellar Ataxia Type 31

SCA31

Spinocerebellar Ataxia 16q22-Linked

Spinocerebellar Ataxia, 16q22-Linked

Pure Spinocerebellar Ataxia Japanese Type

Sca4 Pure Japanese Type

Ataxia, Spinocerebellar, Type 31

Charcot-Marie-Tooth Disease, Demyelinating, Type 1c

Charcot-Marie-Tooth Disease Type 1c

CMT1C

Hmsn1c

Hmsn Ic

Charcot-Marie-Tooth Disease, Type 1c

Charcot-Marie-Tooth Neuropathy Type 1c

Cmt, Slow Nerve Conduction Type C

Charcot-Marie-Tooth Neuropathy, Type 1c

Neuropathy, Hereditary Motor And Sensory, Type Ic

Cmt Slow Nerve Conduction Type C

Neuropathy Hereditary Motor And Sensory Type 1c

Charcot-Marie-Tooth Disease 1c

Charcot-Marie-Tooth Disease Demyelinating Type 1c

Hereditary Motor And Sensory Neuropathy Ic

Charcot-Marie-Tooth Disease, Type Ic

Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4

Charcot-Marie-Tooth Disease Type 4e

Hereditary Motor And Sensory Neuropathy

Cmt4e

CHN1

Hypomyelinating Neuropathy, Congenital, 1

Charcot-Marie-Tooth Neuropathy Type 4e

Neuropathy, Congenital Hypomyelinating, 1

Ar-Cmt1

Autosomal Recessive Demyelinating Charcot-Marie-Tooth

Cmt4

Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive

Hypomyelination, Severe Congenital

Charcot-Marie-Tooth Disease, Type 4e

Charcot-Marie-Tooth Neuropathy, Type 4e

Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy

Autosomal Recessive Congenital Hypomyelinating Neuropathy

Congenital Amyelinating Neuropathy

Congenital Hypomyelinating Neuropathy Autosomal Recessive

Neuropathy, Congenital Hypomyelinating Or Amyelinating

Severe Congenital Hypomyelination

Hereditary Sensory Motor Neuropathy

Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive

Neuropathy, Hypomyelinating, Congenital, Type 1

Neuropathy, Motor And Sensory, Hereditary

Congenital Hypomyelinating Neuropathy

Hereditary Motor And Sensory Neuropathies

Hereditary Sensorimotor Neuropathy

Hmsn - [Hereditary Motor And Sensory Neuropathy]

Hsmn - [Hereditary Sensory And Motor Neuropathy]

Hereditary Motor And Sensory Neuropathy, Types I-Iv

Cowden Syndrome

Cowden Disease

Multiple Hamartoma Syndrome

Cowden'S Disease

Lhermitte-Duclos Disease

Cd

Cs

Mham

Dysplastic Gangliocytoma Of Cerebellum

Cowden'S Syndrome

Hamartoma Syndrome, Multiple

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome

Sudden Unexplained Nocturnal Death Syndrome

Bangungut

Brugada Type Idiopathic Ventricular Fibrillation

Pokkuri Death Syndrome

Sunds

Idiopathic Ventricular Fibrillation, Brugada Type

Sudden Unexplained Death

Dream Disease

Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome

Sudden Unexplained Death Syndrome

Suds

Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NEDD4 VGNC VGNC:59121
Rattus norvegicus NEDD4 RGD RGD:3157
Macaca mulatta NEDD4 VGNC VGNC:75302
Bos taurus NEDD4 VGNC VGNC:55128
Mus musculus NEDD4 MGD MGI:97297
Felis catus NEDD4 VGNC VGNC:80898
Others NEDD4 NCBI