2. Gene
  3. LDLRAD4 - low density lipoprotein receptor class A domain containing 4 Gene

LDLRAD4 - low density lipoprotein receptor class A domain containing 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含低密度脂蛋白受体 A 类结构域 4

种属: Homo sapiens

同用名: C18orf1

基因 ID: 753 | 基因类型: protein coding

关于 LDLRAD4

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:13,217,682-13,652,754 (from NCBI)

This gene has 40 transcripts (splice variants), 224 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 2.9), prostate (RPKM 1.4) and 24 other tissues.

功能概要

启用 R-SMAD 绑定活动。参与细胞迁移的负调控；上皮间充质转化的负调节；和跨膜受体蛋白丝氨酸/苏氨酸激酶信号通路的负调控。位于早期内体膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables R-SMAD binding activity. Involved in negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

LDLRAD4 基因产物(16)

mRNA Protein Name
NM_001003674.3 NP_001003674.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform gamma 1
NM_001003675.3 NP_001003675.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform gamma 2
NM_001276249.1 NP_001263178.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform delta 1
NM_001276251.2 NP_001263180.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform epsilon 1
NM_001378098.1 NP_001365027.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_001378099.1 NP_001365028.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_001378100.1 NP_001365029.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_001378101.1 NP_001365030.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2
NM_001394662.1 NP_001381591.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_001394663.1 NP_001381592.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_001394664.1 NP_001381593.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2
NM_001394665.1 NP_001381594.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2
NM_001394666.1 NP_001381595.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform 15
NM_001394667.1 NP_001381596.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform 15
NM_181481.5 NP_852146.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_181482.5 NP_852147.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables R-SMAD binding IPI
IPI: 通过物理相互作用推断
24627487 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24627487 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of SMAD protein signal transduction IDA
IDA: 通过直接分析推断
24627487 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
24627487 GOA
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
24627487 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
24627487 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
24627487 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome membrane IDA
IDA: 通过直接分析推断
24627487 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LDLRAD4 蛋白结构

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (16 - 47)

  • 0
  • 100
  • 200
  • 306 a.a.
蛋白主名 其他名称

low-density lipoprotein receptor class A domain-containing protein 4

clone 22

LDLRAD4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LDLRAD4 O15165 NEDD4 Homo sapiens P46934
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07579 LDLRAD4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LDLRAD4 VGNC VGNC:74038
Rattus norvegicus LDLRAD4 RGD RGD:1587105
Felis catus LDLRAD4 VGNC VGNC:80448
Mus musculus LDLRAD4 MGD MGI:1277150
Bos taurus LDLRAD4 VGNC VGNC:30829
Canis familiaris LDLRAD4 VGNC VGNC:42625
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