2. Gene
  3. UVRAG - UV radiation resistance associated Gene

UVRAG - UV radiation resistance associated Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：抗紫外线辐射相关

种属: Homo sapiens

同用名: p63; DHTX; VPS38

基因 ID: 7405 | 基因类型: protein coding

关于 UVRAG

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:75,815,210-76,144,232 (from NCBI)

This gene has 9 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in fat (RPKM 5.6), lymph node (RPKM 3.6) and 24 other tissues.

功能概要

该基因补充了着色性干皮病 C 组细胞的紫外线敏感性，并编码具有 C2 结构域的蛋白质。该蛋白激活 Beclin1-PI (3) KC3 复合物，促进自噬并抑制人结肠癌细胞的增殖和致瘤性。涉及该基因的染色体畸变与左右轴畸形有关，并且该基因的突变与结肠癌有关。[RefSeq 提供，2008 年 7 月]

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting Autophagy and suppressing the proliferation and tumorigenicity of human colon Cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon Cancer. [provided by RefSeq, Jul 2008]

UVRAG 基因产物(5)

mRNA Protein Name
NM_001386671.1 NP_001373600.1 UV radiation resistance-associated gene protein isoform 1
NM_001386672.1 NP_001373601.1 UV radiation resistance-associated gene protein isoform 3
NM_001386673.1 NP_001373602.1 UV radiation resistance-associated gene protein isoform 4
NM_001386674.1 NP_001373603.1 UV radiation resistance-associated gene protein isoform 5
NM_003369.4 NP_003360.2 UV radiation resistance-associated gene protein isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17891140 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA repair IMP
IMP: 通过突变表型推断
22542840 GOA
involved in autophagosome maturation IDA
IDA: 通过直接分析推断
28306502 GOA
involved in autophagy IMP
IMP: 通过突变表型推断
24056303 GOA
involved in centrosome cycle IMP
IMP: 通过突变表型推断
22542840 GOA
involved in double-strand break repair via classical nonhomologous end joining IDA
IDA: 通过直接分析推断
22542840 GOA
involved in maintenance of Golgi location IMP
IMP: 通过突变表型推断
24056303 GOA
involved in phosphatidylinositol-3-phosphate biosynthetic process IDA
IDA: 通过直接分析推断
8999962 GOA
involved in receptor catabolic process IMP
IMP: 通过突变表型推断
20643123 GOA
involved in regulation of autophagy IDA
IDA: 通过直接分析推断
16799551 GOA
involved in regulation of cytokinesis IMP
IMP: 通过突变表型推断
20643123 GOA
involved in regulation of protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
22542840 GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
IMP: 通过突变表型推断
24056303 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of DNA-dependent protein kinase complex IDA
IDA: 通过直接分析推断
22542840 GOA
located in autophagosome membrane IDA
IDA: 通过直接分析推断
28306502 GOA
located in centrosome IDA
IDA: 通过直接分析推断
22542840 GOA
located in early endosome IDA
IDA: 通过直接分析推断
19270696 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
24056303 GOA
located in late endosome IDA
IDA: 通过直接分析推断
19270696 GOA
located in lysosome IDA
IDA: 通过直接分析推断
19270696 GOA
located in midbody IDA
IDA: 通过直接分析推断
20643123 GOA
part of phosphatidylinositol 3-kinase complex, class III IPI
IPI: 通过物理相互作用推断
25490155 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UVRAG 蛋白结构

C2

C2: C2 domain (46 - 95)

Atg14

Atg14: Vacuolar sorting 38 and autophagy-related subunit 14 (185 - 449)

  • 0
  • 200
  • 400
  • 600
  • 699 a.a.
蛋白主名 其他名称

UV radiation resistance-associated gene protein

beclin 1 binding protein

UVRAG 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
22493499
种属内
UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
24056303
种属内
UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
20562859
种属内
UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
34386498
种属内
UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
24056303
种属内
UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
22493499
种属内
UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
24785657
种属内
UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Pull Down
25490155
种属内
UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
24849286
种属内
UVRAG Q9P2Y5 VPS33A Homo sapiens Q96AX1
Anti Tag CoIP
20562859
种属间
UVRAG Q9P2Y5 ap3a_sars2 SARS-CoV-2 P0DTC3
Anti Bait CoIP
34386498
种属间
UVRAG Q9P2Y5 ap3a_sars2 SARS-CoV-2 P0DTC3
Confocal
34386498
种属间
UVRAG Q9P2Y5 ap3a_sars2 SARS-CoV-2 P0DTC3
Anti Tag CoIP
34386498
种属内
UVRAG Q9P2Y5 SH3GLB1 Homo sapiens Q9Y371
Anti Tag CoIP
24056303
种属内
UVRAG Q9P2Y5 SH3GLB1 Homo sapiens Q9Y371
Anti Bait CoIP
24056303
种属内
UVRAG Q9P2Y5 RUBCN Homo sapiens Q92622
Anti Tag CoIP
35271311
种属内
UVRAG Q9P2Y5 RUBCN Homo sapiens Q92622
Anti Tag CoIP
34386498
种属内
UVRAG Q9P2Y5 RUBCN Homo sapiens Q92622
Pull Down
21062745
种属内
UVRAG Q9P2Y5 RUBCN Homo sapiens Q92622
Anti Tag CoIP
20562859
种属内
UVRAG Q9P2Y5 BAX Homo sapiens Q07812
Anti Bait CoIP
21597469
种属内
UVRAG Q9P2Y5 BAX Homo sapiens Q07812
Anti Tag CoIP
21597469
种属内
UVRAG Q9P2Y5 RINT1 Homo sapiens Q6NUQ1
Anti Tag CoIP
24056303
种属内
UVRAG Q9P2Y5 RINT1 Homo sapiens Q6NUQ1
Anti Bait CoIP
24056303
种属间
UVRAG Q9P2Y5 Slamf1 Mus musculus Q9QUM4
Anti Bait CoIP
22493499
种属间
UVRAG Q9P2Y5 Slamf1 Mus musculus Q9QUM4
Anti Tag CoIP
22493499
种属内
UVRAG Q9P2Y5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
20562859
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cholecystolithiasis
Cornea Cancer

Malignant Neoplasm Of Cornea

Neoplasm Of Cornea

Corneal Tumor

Malignant Corneal Tumor

Malignant Tumor Of Cornea

Primary Malignant Neoplasm Of Cornea
Situs Inversus

Situs Inversus Viscerum

Laterality Sequence

Complete Transposition

Siv
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-156237 Beclin1-ATG14L interaction inhibitor 1 Inhibitor 99.88% 否
HY-152100 CUR5g Inhibitor 98.69% 否
HY-RS15588 UVRAG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta UVRAG VGNC VGNC:78751
Felis catus UVRAG VGNC VGNC:66909
Rattus norvegicus UVRAG RGD RGD:1589754
Mus musculus UVRAG MGD MGI:1925860
Bos taurus UVRAG VGNC VGNC:36751
Canis familiaris UVRAG VGNC VGNC:48218
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