PIK3C3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

中文名称：磷脂酰肌醇 3-激酶催化亚基 3 型

种属: Homo sapiens

同用名: VPS34; Vps34; hVps34

基因 ID: 5289 | 基因类型: protein coding

关于 PIK3C3

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:41,955,234-42,087,830 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 7.2), brain (RPKM 7.0) and 25 other tissues.

功能概要

启用 1-磷脂酰肌醇-3-激酶活性。参与早期内体到晚期内体的转运和胞质分裂的调节。作用于自噬和蛋白质脂化的上游或内部。位于自溶酶体；晚期内体；和中体。 [由基因组资源联盟提供，2022 年 4 月]

Enables 1-phosphatidylinositol-3-kinase activity. Involved in early endosome to late endosome transport and regulation of cytokinesis. Acts upstream of or within Autophagy and protein lipidation. Located in autolysosome; late endosome; and midbody. [provided by Alliance of Genome Resources, Apr 2022]

PIK3C3 基因产物(5)

mRNA	Protein	Name
XM_047437549.1	XP_047293505.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1
NM_002647.4	NP_002638.2	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 1
XM_047437550.1	XP_047293506.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2
XM_047437551.1	XP_047293507.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X3
NM_001308020.2	NP_001294949.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 1-phosphatidylinositol-3-kinase activity	IDA IDA: 通过直接分析推断	7628435	GOA
enables 1-phosphatidylinositol-3-kinase activity	IMP IMP: 通过突变表型推断	20208530	GOA
enables kinase activity	IDA IDA: 通过直接分析推断	25327288	GOA
enables phosphatidylinositol kinase activity	IDA IDA: 通过直接分析推断	7628435	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7504174	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in autophagosome assembly	IDA IDA: 通过直接分析推断	33637724	GOA
involved in autophagosome maturation	IDA IDA: 通过直接分析推断	10625637	GOA
acts upstream of or within autophagy	IMP IMP: 通过突变表型推断	25327288	GOA
involved in early endosome to late endosome transport	IDA IDA: 通过直接分析推断	14617358	GOA
involved in early endosome to late endosome transport	IMP IMP: 通过突变表型推断	14617358	GOA
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: 通过直接分析推断	7628435	GOA
involved in phosphatidylinositol-3-phosphate biosynthetic process	IDA IDA: 通过直接分析推断	8999962	GOA
involved in positive regulation by host of viral genome replication	IDA IDA: 通过直接分析推断	34320401	GOA
acts upstream of or within protein lipidation	IMP IMP: 通过突变表型推断	25327288	GOA
involved in regulation of autophagy	IDA IDA: 通过直接分析推断	16799551	GOA
involved in regulation of cytokinesis	IMP IMP: 通过突变表型推断	20208530	GOA
involved in regulation of macroautophagy	IDA IDA: 通过直接分析推断	10625637	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in autolysosome	IDA IDA: 通过直接分析推断	25327288	GOA
located in late endosome	IDA IDA: 通过直接分析推断	14617358	GOA
located in midbody	IDA IDA: 通过直接分析推断	20208530	GOA
part of phosphatidylinositol 3-kinase complex, class III	IPI IPI: 通过物理相互作用推断	25490155	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIK3C3 蛋白结构

PI3K_C2

PI3Ka

PI3_PI4_kinase

0
200
400
600
800
887 a.a.

蛋白主名

其他名称

phosphatidylinositol 3-kinase catalytic subunit type 3

PI3-kinase type 3	PI3K type 3
PtdIns-3-kinase type 3	phosphatidylinositol 3-kinase p100 subunit
phosphoinositide-3-kinase, class 3	vacuolar protein sorting 34 homolog

PIK3C3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	PIK3C3	Q8NEB9	X	Hepatitis B virus	Q17UT5	Anti Bait CoIP	20142477
种属间	PIK3C3	Q8NEB9	X	Hepatitis B virus	Q17UT5	Anti Tag CoIP	20142477
种属内	PIK3C3	Q8NEB9	NRBF2	Homo sapiens	Q96F24	Anti Bait CoIP	24785657
种属内	PIK3C3	Q8NEB9	NRBF2	Homo sapiens	Q96F24	Anti Tag CoIP	20562859
种属内	PIK3C3	Q8NEB9	NRBF2	Homo sapiens	Q96F24	Anti Tag CoIP	24785657
种属内	PIK3C3	Q8NEB9	ATG14	Homo sapiens	Q6ZNE5	Anti Tag CoIP	19050071
种属内	PIK3C3	Q8NEB9	ATG14	Homo sapiens	Q6ZNE5	Anti Tag CoIP	20562859
种属内	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	35271311
种属内	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Bait CoIP	24785657
种属内	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	20562859
种属内	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Bait CoIP	24056303
种属内	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Phosphotransferase	25490155
种属内	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	24785657
种属内	PIK3C3	Q8NEB9	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	35271311
种属内	PIK3C3	Q8NEB9	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	20562859
种属内	PIK3C3	Q8NEB9	RUBCN	Homo sapiens	Q92622	Anti Bait CoIP	21062745

种属间: 跨种属相互作用 种属内: 同种属相互作用

PIK3C3 抗体

目录号	产品名	应用	反应物种
HY-P83044	PIK3C3 Antibody (YA2789)	WB, IHC-P	Human, Mouse, Rat

关联疾病

疾病名称

别名

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Danon Disease

Pseudoglycogenosis Ii	Antopol Disease
Glycogen Storage Disease Iib	Glycogen Storage Disease Type 2b
Glycogen Storage Disease Type Iib	Gsd2b
Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency	Vacuolar Cardiomyopathy And Myopathy X-Linked
Vacuolar Cardiomyopathy And Myopathy, X-Linked	Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency, Formerly
Gsd2b, Formerly	Gsd Iib, Formerly
Glycogen Storage Cardiomyopathy	Glycogen Storage Disease Limited To The Heart
Pseudoglycogenosis 2	X-Linked Vacuolar Cardiomyopathy And Myopathy
Lysosomal Glycogen Storage Disease With Normal Acid Maltase	Glycogen Storage Disease Due To Lamp-2 Deficiency
Gsd Due To Lamp-2 Deficiency	Glycogenosis Due To Lamp-2 Deficiency
Lysosomal Glycogen Storage Disease With Normal Acid Maltase Activity	DAND
Gsd-Iib

Myopathy, X-Linked, With Excessive Autophagy

X-Linked Myopathy With Excessive Autophagy	Xmea
MEAX	Vacuolar Myopathy

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Centronuclear Myopathy

Myopathy, Centronuclear	Myotubular Myopathy
Cnm	Myopathy, Myotubular
Congenital Structural Myopathy

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Myopathy, Centronuclear, X-Linked

X-Linked Myotubular Myopathy	Xlmtm
X-Linked Centronuclear Myopathy	Xlcnm
CNMX	Mtm1
Myotubular Myopathy, X-Linked	Mtmx
Myotubular Myopathy 1	Centronuclear Myopathy X-Linked
Myotubular Myopathy	Mtm
Cnm	Xmtm
Myotubular Myopathy Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12481	SAR405	Inhibitor	99.74%	否
HY-137506	XST-14		99.26%	否
HY-12481A	SAR405 R enantiomer		99.94%	否
HY-RS10520	PIK3C3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS10521	Pik3c3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS10522	Pik3c3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PIK3C3	VGNC	VGNC:44554
Bos taurus	PIK3C3	VGNC	VGNC:32888
Macaca mulatta	PIK3C3	VGNC	VGNC:75994
Mus musculus	PIK3C3	MGD	MGI:2445019
Rattus norvegicus	PIK3C3	RGD	RGD:620899
Felis catus	PIK3C3	VGNC	VGNC:68853
Others	PIK3C3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PIK3C3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

关于 PIK3C3

功能概要

PIK3C3 基因产物(5)

PIK3C3 蛋白结构

PIK3C3 蛋白互作信息

PIK3C3 抗体

关联疾病

直系同源

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PIK3C3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

关于 PIK3C3

功能概要

PIK3C3 基因产物(5)

PIK3C3 蛋白结构

PIK3C3 蛋白互作信息

PIK3C3 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z