KLHL20 - kelch like family member 20 Gene

中文名称：kelch 样家族成员 20

种属: Homo sapiens

同用名: KHLHX; KLEIP; KLHLX

基因 ID: 27252 | 基因类型: protein coding

关于 KLHL20

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,714,981-173,786,692 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 54 paralogues. Ubiquitous expression in testis (RPKM 10.0), fat (RPKM 7.7) and 25 other tissues.

功能概要

由该基因编码的蛋白质是 kelch 蛋白质家族的成员，其特征是具有 44-56 个氨基酸重复基序。 kelch 基序出现在许多不同的多肽环境中，并包含多个潜在的蛋白质-蛋白质接触位点。这个家族的成员存在于整个细胞和细胞外，具有不同的活动。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]

KLHL20 基因产物(1)

mRNA	Protein	Name
NM_014458.4	NP_055273.2	kelch-like protein 20

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	20389280	GOA
enables type II interferon binding	IDA IDA: 通过直接分析推断	20389280	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	24768539	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	20389280	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi to endosome transport	IMP IMP: 通过突变表型推断	24768539	GOA
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	20389280	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	20389280	GOA
involved in protein K33-linked ubiquitination	IDA IDA: 通过直接分析推断	24768539	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	20389280	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cul3-RING ubiquitin ligase complex	IDA IDA: 通过直接分析推断	20389280	GOA
located in PML body	IDA IDA: 通过直接分析推断	20389280	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	20389280	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	24768539	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLHL20 蛋白结构

BTB

BACK

Kelch_1

0
100
200
300
400
500
609 a.a.

蛋白主名

其他名称

kelch-like protein 20

Kelch motif containing protein

KLHL20 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	KLHL20	Q9Y2M5	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590	Pull Down	21840486
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590	IF	20389280
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590	Anti Tag CoIP	20389280
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590	Anti Tag CoIP	25619834
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590-1	Anti Tag CoIP	21840486
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590-1	Pull Down	25619834
Intra	KLHL20	Q9Y2M5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	DAPK1	Homo sapiens	P53355	Anti Bait CoIP	20389280
Intra	KLHL20	Q9Y2M5	DAPK1	Homo sapiens	P53355	Anti Tag CoIP	20389280
Intra	KLHL20	Q9Y2M5	DAPK1	Homo sapiens	P53355	Anti Tag CoIP	25619834
Intra	KLHL20	Q9Y2M5	DAPK1	Homo sapiens	P53355	Pull Down	25619834
Intra	KLHL20	Q9Y2M5	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	20389280
Intra	KLHL20	Q9Y2M5	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	25619834
Intra	KLHL20	Q9Y2M5	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	33961781
Intra	KLHL20	Q9Y2M5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	IVNS1ABP	Homo sapiens	Q9Y6Y0	Pull Down	25619834
Intra	KLHL20	Q9Y2M5	IVNS1ABP	Homo sapiens	Q9Y6Y0	Anti Bait CoIP	25619834
Intra	KLHL20	Q9Y2M5	IVNS1ABP	Homo sapiens	Q9Y6Y0	Anti Tag CoIP	25619834
Intra	KLHL20	Q9Y2M5	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	PHYH	Homo sapiens	O14832	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	PHYH	Homo sapiens	O14832	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	PHYH	Homo sapiens	O14832	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	DBH	Homo sapiens	P09172	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	DBH	Homo sapiens	P09172	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	DBH	Homo sapiens	P09172	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	PRMT6	Homo sapiens	Q96LA8	Y2H	23455924
Intra	KLHL20	Q9Y2M5	PRMT6	Homo sapiens	Q96LA8	Anti Tag CoIP	23455924

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes	ASGD5
Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07362	KLHL20 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	KLHL20	VGNC	VGNC:30649
Macaca mulatta	KLHL20	VGNC	VGNC:74120
Felis catus	KLHL20	VGNC	VGNC:81199
Mus musculus	KLHL20	MGD	MGI:2444855
Canis familiaris	KLHL20	VGNC	VGNC:42455
Rattus norvegicus	KLHL20	RGD	RGD:1309490

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