2. Gene
  3. PML - PML nuclear body scaffold Gene

PML - PML nuclear body scaffold Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PML 核体支架

种属: Homo sapiens

同用名: MYL; RNF71; PP8675; TRIM19

基因 ID: 5371 | 基因类型: protein coding

关于 PML

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,994,716-74,047,827 (from NCBI)

This gene has 22 transcripts (splice variants), 157 orthologues, 80 paralogues and is associated with 76 phenotypes. Ubiquitous expression in fat (RPKM 11.8), spleen (RPKM 8.1) and 25 other tissues.

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。这种磷蛋白定位于核体，在核体中起转录因子和肿瘤抑制因子的作用。它的表达与细胞周期相关，它调节 p53 对致癌信号的反应。该基因通常参与与急性早幼粒细胞白血病 (APL) 相关的视黄酸受体 α 基因的易位。该基因的广泛选择性剪接导致蛋白质中心和 C 末端区域的多种变异；所有变体编码相同的 N 末端。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PML 基因产物(9)

mRNA Protein Name
NM_002675.4 NP_002666.1 protein PML isoform 6
NM_033238.3 NP_150241.2 protein PML isoform 1
NM_033239.3 NP_150242.1 protein PML isoform 9
NM_033240.3 NP_150243.2 protein PML isoform 2
NM_033244.4 NP_150247.2 protein PML isoform 5
NM_033246.3 NP_150249.1 protein PML isoform 7
NM_033247.3 NP_150250.2 protein PML isoform 8
NM_033249.3 NP_150252.1 protein PML isoform 10
NM_033250.3 NP_150253.2 protein PML isoform 11
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SUMO binding IPI
IPI: 通过物理相互作用推断
17081985 GOA
enables SUMO transferase activity EXP
EXP: 通过实验结果推断
12393906 GOA
enables cobalt ion binding IDA
IDA: 通过直接分析推断
7729428 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
20719947 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9294197 GOA
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
7935403 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
9230084 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
11080164 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
12915590 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
7729428 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in PML body organization IDA
IDA: 通过直接分析推断
8643677 GOA
involved in PML body organization IMP
IMP: 通过突变表型推断
17081985 GOA
involved in apoptotic process IDA
IDA: 通过直接分析推断
9583681 GOA
involved in cellular senescence IDA
IDA: 通过直接分析推断
22002537 GOA
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
11259576 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
18248090 GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage IDA
IDA: 通过直接分析推断
12402044 GOA
acts upstream of or within maintenance of protein location in nucleus IDA
IDA: 通过直接分析推断
17332504 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
7935403 GOA
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
16915281 GOA
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
7935403 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12006491 GOA
involved in negative regulation of mitotic cell cycle IDA
IDA: 通过直接分析推断
9395203 GOA
involved in negative regulation of telomere maintenance via telomerase IMP
IMP: 通过突变表型推断
19567472 GOA
involved in negative regulation of translation in response to oxidative stress IDA
IDA: 通过直接分析推断
16915281 GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
15195100 GOA
involved in positive regulation of apoptotic process involved in mammary gland involution IDA
IDA: 通过直接分析推断
11080164 GOA
involved in positive regulation of defense response to virus by host IMP
IMP: 通过突变表型推断
16873256 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
21803845 GOA
involved in positive regulation of protein localization to chromosome, telomeric region IDA
IDA: 通过直接分析推断
22641345 GOA
involved in positive regulation of telomere maintenance IMP
IMP: 通过突变表型推断
22641345 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
22406621 GOA
involved in protein stabilization IDA
IDA: 通过直接分析推断
12773567 GOA
involved in protein targeting IDA
IDA: 通过直接分析推断
11080164 GOA
involved in protein targeting IMP
IMP: 通过突变表型推断
15195100 GOA
involved in protein-containing complex assembly IDA
IDA: 通过直接分析推断
12915590 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
23007646 GOA
involved in regulation of cell cycle IDA
IDA: 通过直接分析推断
9583681 GOA
involved in regulation of double-strand break repair IMP
IMP: 通过突变表型推断
21639834 GOA
involved in response to cytokine IDA
IDA: 通过直接分析推断
9412458 GOA
involved in response to hypoxia IDA
IDA: 通过直接分析推断
16915281 GOA
involved in suppression of viral release by host IDA
IDA: 通过直接分析推断
18248090 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
9412458 GOA
located in chromosome, telomeric region IDA
IDA: 通过直接分析推断
26119943 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
9885291 GOA
located in nuclear matrix IDA
IDA: 通过直接分析推断
11080164 GOA
located in nuclear membrane IDA
IDA: 通过直接分析推断
16778193 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
15195100 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
12915590 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9294197 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PML 蛋白结构

zf-B_box

zf-B_box: B-box zinc finger (126 - 165)

DUF3583

DUF3583: Protein of unknown function (DUF3583) (240 - 570)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 882 a.a.
蛋白主名 其他名称

protein PML

E3 SUMO-protein ligase PML

PML 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PML P29590 PER2 Homo sapiens O15055
Anti Bait CoIP
22274616
Intra PML P29590 PER2 Homo sapiens O15055
IF
22274616
Intra PML P29590 MAPK7 Homo sapiens Q13164
Protein Kinase Assay
20832753
Intra PML P29590 MAPK7 Homo sapiens Q13164
Anti Bait CoIP
20832753
Intra PML P29590 TBX2 Homo sapiens Q13207
Anti Bait CoIP
22002537
Intra PML P29590 TET2 Homo sapiens Q6N021
Anti Bait CoIP
29735542
Intra PML P29590 PSMA3 Homo sapiens P25788
Anti Tag CoIP
21988832
Intra PML P29590 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra PML P29590 TP53 Homo sapiens P04637
PLA
25241761
Intra PML P29590 TP53 Homo sapiens P04637
Confocal
21057547
Intra PML P29590 TP53 Homo sapiens P04637
Anti Bait CoIP
12915590
Intra PML P29590 MDM2 Homo sapiens Q00987
Imaging
12915590
Intra PML P29590 MDM2 Homo sapiens Q00987
Anti Bait CoIP
12915590
Intra PML P29590 FAS Homo sapiens P25445
Anti Bait CoIP
21803845
Intra PML P29590 ZBTB16 Homo sapiens Q05516
Y2H
9294197
Intra PML P29590 ZBTB16 Homo sapiens Q05516
Imaging
9294197
Intra PML P29590 TGIF1 Homo sapiens Q15583
IF
18511908
Intra PML P29590 KLHL20 Homo sapiens Q9Y2M5
Confocal
21840486
Intra PML P29590 KLHL20 Homo sapiens Q9Y2M5
Competition Binding
20389280
Intra PML P29590 KLHL20 Homo sapiens Q9Y2M5
Anti Tag CoIP
21840486
Intra PML P29590 KLHL20 Homo sapiens Q9Y2M5
Anti Bait CoIP
21840486
Intra PML P29590 DAXX Homo sapiens Q9UER7
Anti Bait CoIP
21840486
Intra PML P29590 SUMO1 Homo sapiens P63165
Anti Tag CoIP
17036045
Intra PML P29590 SUMO1 Homo sapiens P63165
Anti Bait CoIP
21057547
Cross PML P29590 p03243-1 Human adenovirus C P03243-1
Anti Bait CoIP
20639899
Cross PML P29590 p03243-1 Human adenovirus C P03243-1
Confocal
20639899
Cross PML P29590 P27958-PRO_0000037566 Hepatitis C virus P27958-PRO_0000037566
Anti Bait CoIP
16322229
Cross PML P29590 P27958-PRO_0000037566 Hepatitis C virus P27958-PRO_0000037566
IF
16322229
Cross PML P29590 gag-pro-pol Moloney murine leukemia virus Q8UN00
Pull Down
22685230
Cross PML P29590 gag-pro-pol Moloney murine leukemia virus Q8UN00
Confocal
22685230
Cross PML P29590 gag-pro-pol Moloney murine leukemia virus Q8UN00
Anti Tag CoIP
22685230
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Rabies

Lyssa

Hydrophobia

St Hubert Disease
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Bloom Syndrome

BLM

Bs

Bls

Bloom-Torre-Machacek Syndrome

Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 1

Mgrisce1

Congenital Telangiectatic Erythema

Congenital Telangiectatic Erythema Syndrome

Growth Deficiency, Sun-Sensitive, Telangiectatic, Hypo And Hyperpigmented Skin, Predisposition To Malignancy And Chromosomal Instability

Bloom'S Syndrome

Bsyn
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Dentatorubral-Pallidoluysian Atrophy

DRPLA

Naito-Oyanagi Disease

Haw River Syndrome

Myoclonic Epilepsy With Choreoathetosis

Nod

Ataxia, Chorea, Seizures, And Dementia

Dentatorubropallidoluysian Atrophy

Hrs

Naito Oyanagi Disease

Dentatorubral Pallidoluysian Atrophy

Dentatorubro-Pallidoluysian Atrophy

Myoclonic Epilepsies, Progressive

Atrophy, Pallidoluysian, Dentatorubral
Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Alpha-Thalassemia

Alpha Thalassemia

Alpha Thalassaemia

Alpha Plus Thalassemia

Thalassemia, Alpha-

Thalassemias, Alpha-

A-Thalassemia

Α-Thalassemia

A-THAL

Thalassemia

Alpha Thalassaemia Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N10633 LSTc ≥98.0% 否
HY-127130 Spicamycin / 否
HY-RS10765 PML Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-U00237B L-771688 hydrochloride / 否
HY-118156 L-699333 / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PML MGD MGI:104662
Macaca mulatta PML VGNC VGNC:99295
Bos taurus PML VGNC VGNC:99292
Felis catus PML VGNC VGNC:99293
Canis familiaris PML VGNC VGNC:99291
Rattus norvegicus PML RGD RGD:1562602
Others PML NCBI
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