2. Apoptosis Anti-infection
  3. Bcl-2 Family Apoptosis Fungal Antibiotic
  4. Spicamycin

Spicamycin 是一种具有抗真菌和抗肿瘤活性的腺嘌呤核苷类抗生素。Spicamycin 也是髓系白血病细胞分化的有效诱导剂。Spicamycin 通过下调 Bcl-2 表达和调节 PML 蛋白诱导 NB4 细胞凋亡 (apoptosis)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Spicamycin Chemical Structure

Spicamycin Chemical Structure

CAS No. : 87099-85-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Spicamycin 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

查看 Antibiotic 亚型特异性产品:

查看所有亚型
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Spicamycin, an adenine nucleoside antibiotic with antifungal and antitumor activities. Spicamycin is also a potent inducer of differentiation of myeloid leukemia cells. Spicamycin induces apoptosis in NB4 cells via down-regulation of Bcl-2 expression and modulation of PML protein[1][2].

IC50 & Target[1]

Bcl-2

 

体外研究
(In Vitro)

Spicamycin (10-160 ng/mL; 0-5 d) 有效抑制 NB4、NKM-1 和 HL-60 细胞的增殖和活力[1]。
Spicamycin (20 ng/mL, 80 ng/mL; 48 h) 诱导 NB4、HL-60 和 NKM-1 细胞凋亡[1]。
Spicamycin (20 ng /mL、40 ng /mL; 36 h) 下调 NB4 细胞中 Bcl-2 的表达[1]。
Spicamycin (2.5-640 ng/mL) 对酿酒酵母菌 ATCC 9763、假丝酵母菌 IFO 0396 和mentagrophytotrichophyton 的 MIC 值分别为 25μg/mL、25μg/mL 和 1.56 μg/mL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Spicamycin 相关抗体:

Cell Viability Assay[1]

Cell Line: NB4, HL-60, NKM-1, NOP-1 and Daudi cells
Concentration: 10 ng/mL, 20 ng/mL, 40 ng/mL, 80 ng/mL, 160 ng/mL
Incubation Time: 0, 1, 2, 3, 4, and 5 days or 72 hours
Result: Completely inhibited cell proliferation and viability of NB4 and NKM-1 at 40 ng/mL, of HL-60 at 80 ng/mL, but failed to inhibit NOP-1 and Daudi cells at higher dose of 160 ng/mL.
Inhibited cells viability of IC50s of 18.2 ng/mL, 28.6 ng/mL, 23.8 ng/mL, 74.9 ng/mL, and 37.4 ng/mL, respectively.

Western Blot Analysis[1]

Cell Line: NB4 cells
Concentration: 20 ng/mL, 40 ng/mL
Incubation Time: 36 hours
Result: Reduced the Bcl-2 expression without affecting Bcl-xL and Bax expression.
体内研究
(In Vivo)

Spicamycin (0.125-2 mg/kg; 腹腔注射; 每天 1 次，共 9 天) 对 P388 小鼠白血病模型具有抗癌活性[2]。
Spicamycin 对小鼠的 LD50 值为 40 mg/kg[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P388 Mouse Leukemia model[2]
Dosage: 0.125, 0.25, 0.5, 1.0, and 2.0 mg/kg
Administration: Intraperitoneal injection; once daily for 9 days
Result: Showed no biotoxicity at dose below 2.0 mg/kg.
分子量

621.77

Formula

C30H51N7O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Spicamycin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spicamycin87099-85-2Bcl-2 FamilyApoptosisFungalAntibioticInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Spicamycin
目录号：
HY-127130
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z