MAPK7 - mitogen-activated protein kinase 7 Gene

中文名称：丝裂原活化蛋白激酶 7

种属: Homo sapiens

同用名: BMK1; ERK4; ERK5; PRKM7

基因 ID: 5598 | 基因类型: protein coding

关于 MAPK7

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,377,750-19,383,544 (from NCBI)

This gene has 18 transcripts (splice variants), 193 orthologues and 19 paralogues. Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是 MAP 激酶家族的成员。 MAP 激酶作为多种生化信号的整合点，参与多种细胞过程，如增殖、分化、转录调控和发育。该激酶由丝裂原活化蛋白激酶激酶 5 (MAP2K5/MEK5) 特异性激活。它参与各种受体分子的下游信号过程，包括受体型激酶和 G 蛋白偶联受体。响应细胞外信号，该激酶转移到细胞核，在那里它通过磷酸化和激活不同的转录因子来调节基因表达。已经报道了编码两种不同同种型的该基因的四种可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

MAPK7 基因产物(15)

mRNA	Protein	Name
XM_006721558.4	XP_006721621.1	mitogen-activated protein kinase 7 isoform X1
XM_047436401.1	XP_047292357.1	mitogen-activated protein kinase 7 isoform X1
NM_002749.4	NP_002740.2	mitogen-activated protein kinase 7 isoform 1
NM_139034.3	NP_620603.2	mitogen-activated protein kinase 7 isoform 1
XM_047436406.1	XP_047292362.1	mitogen-activated protein kinase 7 isoform X2
XM_047436405.1	XP_047292361.1	mitogen-activated protein kinase 7 isoform X2
XM_006721559.4	XP_006721622.1	mitogen-activated protein kinase 7 isoform X1
XM_047436407.1	XP_047292363.1	mitogen-activated protein kinase 7 isoform X3
XM_047436404.1	XP_047292360.1	mitogen-activated protein kinase 7 isoform X2
NM_139032.3	NP_620601.1	mitogen-activated protein kinase 7 isoform 2
XM_047436402.1	XP_047292358.1	mitogen-activated protein kinase 7 isoform X1
XM_011523957.4	XP_011522259.1	mitogen-activated protein kinase 7 isoform X4
XM_006721557.4	XP_006721620.1	mitogen-activated protein kinase 7 isoform X1
XM_047436403.1	XP_047292359.1	mitogen-activated protein kinase 7 isoform X1
NM_139033.3	NP_620602.2	mitogen-activated protein kinase 7 isoform 1

MAPK7 蛋白结构

Pkinase

0
200
400
600
816 a.a.

蛋白主名

其他名称

mitogen-activated protein kinase 7

BMK-1	BMK1 kinase
ERK-5	MAP kinase 7
MAPK 7	big MAP kinase 1
extracellular-signal-regulated kinase 5

MAPK7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MAPK7	Q13164	UBE2C	Homo sapiens	Q5TZN3	Y2H Prey Pooling	25416956
Intra	MAPK7	Q13164	UBE2C	Homo sapiens	Q5TZN3	Validated Y2H	25416956
Intra	MAPK7	Q13164	CCDC6	Homo sapiens	Q16204	Validated Y2H	32296183
Intra	MAPK7	Q13164	PML	Homo sapiens	P29590	Anti Bait CoIP	20832753
Intra	MAPK7	Q13164	PML	Homo sapiens	P29590	IF	20832753
Intra	MAPK7	Q13164	BAG2	Homo sapiens	O95816	Anti Tag CoIP	31980649

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Multiple Endocrine Neoplasia, Type Iia

Multiple Endocrine Neoplasia Type 2a	Sipple Syndrome
Multiple Endocrine Neoplasia Type 2	MEN2A
Men2	Ptc Syndrome
Multiple Endocrine Neoplasia, Type 2	Multiple Endocrine Neoplasia Iia
Men 2a	Multiple Endocrine Neoplasia, Type 2a
Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma	Multiple Endocrine Neoplasia Ii
Men2 Syndrome	Men-2a Syndrome
Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma	Multiple Neoplasia 2a
Multiple Neoplasia Type 2

Scoliosis

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Purulent Acute Otitis Media

Acute Suppurative Otitis Media	Acute Or Subacute Suppurative Otitis Media
Acute Or Subacute Purulent Otitis Media

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Scoliosis, Isolated 1

Adolescent Idiopathic Scoliosis	Scoliosis, Isolated, Susceptibility To, 1
Ais	IS1
Adolescent Isolated Scoliosis	Scoliosis, Idiopathic 1
Late Onset Idiopathic Scoliosis	Idiopathic Adolescent Scoliosis
Scoliosis, Idiopathic, Susceptibility To, Type 1

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Neuropathy, Hereditary Sensory And Autonomic, Type Iia

Hereditary Sensory And Autonomic Neuropathy Type 2	Hsan2
HSAN2A	Morvan Disease
Hereditary Sensory And Autonomic Neuropathy Type Ii	Neurogenic Acroosteolysis
Hsan Iia	Hsn2a
Hsn Iia	Neuropathy, Progressive Sensory, Of Children
Neuropathy, Congenital Sensory	Neuropathy, Hereditary Sensory And Autonomic, Type Ii
Hereditary Sensory And Autonomic Neuropathy Type 2a	Hereditary Sensory And Autonomic Neuropathy Type Iia
Hsanii	Congenital Sensory Neuropathy
Hsan Type Ii	Morvan Syndrome
Neuropathy, Hereditary Sensory And Autonomic, Type 2a	Neuropathy, Hereditary Sensory, Type Iia
Acroosteolysis, Neurogenic	Acroosteolysis, Giaccai Type
Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive	Hereditary Sensory Autonomic Neuropathy Type 2
Giaccai Type Acroosteolysis	Hereditary Sensory Neuropathy Type 2
Hereditary Sensory Radicular Neuropathy, Recessive Form	Hsan2b
Hsan2c	Hsan2d
Hsn Type Ii	Autosomal Recessive Sensory Radicular Neuropathy
Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome	Morvan Fibrillary Chorea
Neuropathy, Hereditary Sensory And Autonomic, 2a	Acroosteolysis Giaccai Type
Hereditary Sensory Neuropathy Type Iia	Hereditary Sensory Radicular Neuropathy Autosomal Recessive
Progressive Sensory Neuropathy Of Children	Neuropathy Congenital Sensory
Charcot-Marie-Tooth Disease	Neuropathy, Sensory And Autonomic, Hereditary, Type Iia
Morvan'S Disease	Hereditary Sensory Autonomic Neuropathy, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii	Sensory Neuropathy, Hereditary
Neuropathy, Hereditary Sensory And Autonomic, Type Iib

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148063	DB0614		98.80%	否
HY-148061	DB1113		99.28%	否
HY-148065	FMF-06-098-1		/	否
HY-149412	MHJ-627	Inhibitor	/	否
HY-RS08118	MAPK7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS08119	Mapk7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS08120	MAPK7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	MAPK7	VGNC	VGNC:68171
Bos taurus	MAPK7	VGNC	VGNC:31222
Mus musculus	MAPK7	MGD	MGI:1346347
Rattus norvegicus	MAPK7	RGD	RGD:621505
Canis familiaris	MAPK7	VGNC	VGNC:43000
Macaca mulatta	MAPK7	VGNC	VGNC:74648
Others	MAPK7	NCBI

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