2. Gene
  3. CCDC6 - coiled-coil domain containing 6 Gene

CCDC6 - coiled-coil domain containing 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含卷曲螺旋结构域 6

种属: Homo sapiens

同用名: H4; PTC; TPC; PTC1; TST1; D10S170

基因 ID: 8030 | 基因类型: protein coding

关于 CCDC6

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:59,788,747-59,906,556 (from NCBI)

This gene has 3 transcripts (splice variants), 223 orthologues and is associated with 78 phenotypes. Ubiquitous expression in esophagus (RPKM 21.3), brain (RPKM 15.5) and 25 other tissues.

功能概要

该基因编码含有卷曲螺旋结构域的蛋白质。所编码的蛋白质普遍表达，可能起到肿瘤抑制因子的作用。导致包含该基因的一部分和 RET 原癌基因的细胞内激酶编码域的融合基因表达的染色体重排是甲状腺乳头状癌的原因。[RefSeq 提供，2010 年 9 月]

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the RET proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

CCDC6 基因产物(1)

mRNA Protein Name
NM_005436.5 NP_005427.2 coiled-coil domain-containing protein 6
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23108047 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCDC6 蛋白结构

DUF2046

DUF2046: Uncharacterized conserved protein H4 (DUF2046) (2 - 341)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 474 a.a.
蛋白主名 其他名称

coiled-coil domain-containing protein 6

papillary thyroid carcinoma-encoded protein

CCDC6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CCDC6 Q16204 LUZP4 Homo sapiens Q9P127
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 LUZP4 Homo sapiens Q9P127
Validated Y2H
32296183
Intra CCDC6 Q16204 LUZP4 Homo sapiens Q9P127
Y2H Array
32296183
Intra CCDC6 Q16204 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra CCDC6 Q16204 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 ZNF774 Homo sapiens Q6NX45
Validated Y2H
32296183
Intra CCDC6 Q16204 PPP4C Homo sapiens P60510
Anti Tag CoIP
33961781
Intra CCDC6 Q16204 PPP4C Homo sapiens P60510
Anti Tag CoIP
28514442
Intra CCDC6 Q16204 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra CCDC6 Q16204 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra CCDC6 Q16204 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra CCDC6 Q16204 CYTH4 Homo sapiens Q9UIA0
Y2H Array
32296183
Intra CCDC6 Q16204 CYTH4 Homo sapiens Q9UIA0
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 CYTH4 Homo sapiens Q9UIA0
Validated Y2H
32296183
Intra CCDC6 Q16204 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra CCDC6 Q16204 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra CCDC6 Q16204 SNAPC1 Homo sapiens Q16533
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 SNAPC1 Homo sapiens Q16533
Validated Y2H
32296183
Intra CCDC6 Q16204 SNAPC1 Homo sapiens Q16533
Y2H Array
32296183
Intra CCDC6 Q16204 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
Intra CCDC6 Q16204 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 LHX3 Homo sapiens Q9UBR4-2
Validated Y2H
32296183
Intra CCDC6 Q16204 MAPK7 Homo sapiens Q13164
Y2H Array
32296183
Intra CCDC6 Q16204 MAPK7 Homo sapiens Q13164
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra CCDC6 Q16204 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra CCDC6 Q16204 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 CENPQ Homo sapiens Q7L2Z9
Validated Y2H
32296183
Intra CCDC6 Q16204 CENPQ Homo sapiens Q7L2Z9
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 CENPQ Homo sapiens Q7L2Z9
Y2H Array
32296183
Intra CCDC6 Q16204 TRIM14 Homo sapiens Q14142
Y2H Array
32296183
Intra CCDC6 Q16204 TRIM14 Homo sapiens Q14142
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 FBXW7 Homo sapiens Q969H0
Anti Tag CoIP
23108047
Intra CCDC6 Q16204 FBXW7 Homo sapiens Q969H0
Anti Bait CoIP
23108047
Intra CCDC6 Q16204 ZNF620 Homo sapiens Q6ZNG0
Validated Y2H
32296183
Intra CCDC6 Q16204 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra CCDC6 Q16204 ATF5 Homo sapiens Q9Y2D1
Y2H Array
32296183
Intra CCDC6 Q16204 ATF5 Homo sapiens Q9Y2D1
Validated Y2H
32296183
Intra CCDC6 Q16204 ATF5 Homo sapiens Q9Y2D1
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 ANKRD23 Homo sapiens Q86SG2
Validated Y2H
32296183
Intra CCDC6 Q16204 ANKRD23 Homo sapiens Q86SG2
Y2H Array
32296183
Intra CCDC6 Q16204 ANKRD23 Homo sapiens Q86SG2
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 ZNF835 Homo sapiens Q9Y2P0
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra CCDC6 Q16204 ZNF835 Homo sapiens Q9Y2P0
Y2H Array
32296183
Intra CCDC6 Q16204 PIN1 Homo sapiens Q13526
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 PIN1 Homo sapiens Q13526
Y2H Array
32296183
Intra CCDC6 Q16204 LRSAM1 Homo sapiens Q6UWE0
Validated Y2H
32296183
Intra CCDC6 Q16204 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 HMG20A Homo sapiens Q9NP66
Validated Y2H
32296183
Intra CCDC6 Q16204 HMG20A Homo sapiens Q9NP66
Y2H Array
32296183
Intra CCDC6 Q16204 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra CCDC6 Q16204 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra CCDC6 Q16204 PAX6 Homo sapiens P26367
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma

Well-Differentiated Thyroid Carcinoma

Differentiated Thyroid Gland Carcinoma
Papillary Carcinoma

Carcinoma, Papillary

Carcinoma Papillary
Thyroid Gland Cancer

Thyroid Gland Carcinoma

Malignant Neoplasm Of Thyroid Gland

Malignant Tumour Of Thyroid Gland

Thyroid Neoplasm

Thyroid Neoplasms

Neoplasm Of Thyroid Gland

Thyroid Gland Neoplasm

Head And Neck Cancer, Thyroid

Neoplasm Of The Thyroid Gland

Cancer Of The Thyroid

Primary Malignant Neoplasm Of Thyroglossal Duct

Malignant Neoplasm Of Thyroglossal Duct

Primary Malignant Neoplasm Of Thyroid Gland

Thyroglossal Duct Cancer

Toxic Goitre Malignant Tumour

Cancerous Goitre
Internal Hordeolum
Multiple Endocrine Neoplasia, Type Iib

Multiple Endocrine Neoplasia Type 2b

MEN2B

Wagenmann-Froboese Syndrome

Multiple Endocrine Neoplasia Iib

Mucosal Neuroma Syndrome

Multiple Endocrine Neoplasia, Type 3

Multiple Endocrine Neoplasia, Type 2b

Men Iib

Neuromata, Mucosal, With Endocrine Tumors

Multiple Endocrine Neoplasia, Type Iii, Formerly

Men3, Formerly

Men Type Iib

Men 2b

Multiple Endocrine Neoplasia Type 3

Multiple Neoplasia 2b

Neoplasia, Endocrine, Multiple, Type Iib
Thyroid Gland Medullary Carcinoma

Medullary Thyroid Carcinoma

Medullary Carcinoma Of The Thyroid Gland

Ultimobranchial Thyroid Tumor

Ultimobranchial Thyroid Tumour

Thyroid Cancer, Medullary
Commensal Bacterial Infectious Disease
Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma

Follicular Adenocarcinoma

Follicular Adenocarcinoma, Well Differentiated

Follicular Carcinoma

Thyroid Adenocarcinoma

Adenocarcinoma, Follicular
Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma

Anaplastic Thyroid Cancer

Thyroid Cancer, Anaplastic

Thyroid Carcinoma, Anaplastic

Thyroid Carcinoma Anaplastic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-112301 Pralsetinib Inhibitor 99.98% 是
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-133551 WF-47-JS03 Inhibitor 99.63% 否
HY-144131 RET-IN-11 / 否
HY-146710 RET-IN-16 Inhibitor / 否
HY-153676 RET-IN-23 Inhibitor / 否
HY-RS02051 CCDC6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CCDC6 MGD MGI:1923801
Canis familiaris CCDC6 VGNC VGNC:38845
Rattus norvegicus CCDC6 RGD RGD:1587433
Bos taurus CCDC6 VGNC VGNC:26904
Macaca mulatta CCDC6 VGNC VGNC:70825
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