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  2. ATF5 - activating transcription factor 5 Gene

ATF5 - activating transcription factor 5 Gene

中文名称:激活转录因子 5

种属: Homo sapiens

同用名: ATFX; HMFN0395

基因 ID: 22809 | 基因类型: protein coding

关于 ATF5

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,928,906-49,933,935 (from NCBI)

This gene has 5 transcripts (splice variants), 234 orthologues and 1 paralogue. Biased expression in liver (RPKM 197.1), thyroid (RPKM 55.7) and 2 other tissues.

功能概要

启用多种功能,包括 DNA 结合转录激活剂活性、RNA 聚合酶 II 特异性; RNA 聚合酶 II 转录调节区序列特异性 DNA 结合活性;和微管蛋白结合活性。参与多个过程,包括脂肪细胞分化;调节细胞周期过程;和转录调控,DNA 模板化。位于中心体;胞质溶胶;和核质。 [由基因组资源联盟提供,2022 年 4 月]

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and tubulin binding activity. Involved in several processes, including fat cell differentiation; regulation of cell cycle process; and regulation of transcription, DNA-templated. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ATF5 基因产物(3)

mRNA Protein Name
NM_001193646.2 NP_001180575.1 cyclic AMP-dependent transcription factor ATF-5
NM_001290746.2 NP_001277675.1 cyclic AMP-dependent transcription factor ATF-5
NM_012068.6 NP_036200.2 cyclic AMP-dependent transcription factor ATF-5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
16300731 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
20654631 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
15890932 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
21212266 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
25512613 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10373550 GOA
enables tubulin binding IDA
IDA: 通过直接分析推断
26213385 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IPI
IPI: 通过物理相互作用推断
20102225 GOA
located in centrosome IDA
IDA: 通过直接分析推断
26213385 GOA
located in nucleus IDA
IDA: 通过直接分析推断
22528486 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ATF5 蛋白结构

bZIP_1

bZIP_1: bZIP transcription factor (209 - 266)

  • 0
  • 100
  • 200
  • 282 a.a.
蛋白主名 其他名称

cyclic AMP-dependent transcription factor ATF-5

cAMP-dependent transcription factor ATF-5

ATF5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ATF5 Q9Y2D1 CEBPA Homo sapiens P49715 20102225
种属内
ATF5 Q9Y2D1 DISC1 Homo sapiens Q9NRI5
Y2H
12812986
种属内
ATF5 Q9Y2D1 CEBPG Homo sapiens P53567 23661758
种属内
ATF5 Q9Y2D1 CEBPG Homo sapiens P53567 20102225
种属间: 跨种属相互作用 种属内: 同种属相互作用

ATF5 抗体

目录号 产品名 应用 反应物种
HY-P82439 ATF5 Antibody (YA2184) WB, IHC-P, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Cardiomyopathy, Familial Hypertrophic, 15

Hypertrophic Cardiomyopathy 15

CMH15

Cardiomyopathy, Hypertrophic, 15

Cardiomyopathy Familial Hypertrophic 15

Cardiomyopathy, Familial Hypertrophic 15

Cardiomyopathy, Hypertrophic, Familial, Type 15

Triple-Receptor Negative Breast Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ATF5 VGNC VGNC:38211
Rattus norvegicus ATF5 RGD RGD:628902
Macaca mulatta ATF5 VGNC VGNC:108472
Bos taurus ATF5 VGNC VGNC:26243
Mus musculus ATF5 MGD MGI:2141857