2. Gene
  3. PPP4C - protein phosphatase 4 catalytic subunit Gene

PPP4C - protein phosphatase 4 catalytic subunit Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶 4 催化亚基

种属: Homo sapiens

同用名: PP4; PPX; PP-X; PP4C; PPH3; PPP4

基因 ID: 5531 | 基因类型: protein coding

关于 PPP4C

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,075,994-30,085,376 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 31.5), placenta (RPKM 25.7) and 25 other tissues.

功能概要

启用蛋白质丝氨酸/苏氨酸磷酸酶活性。参与通过同源重组调节双链断裂修复。位于胞质溶胶中；核质；和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine Phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PPP4C 基因产物(5)

mRNA Protein Name
NM_001303503.2 NP_001290432.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 1
NM_001303504.2 NP_001290433.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 2
NM_001303506.2 NP_001290435.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 3
NM_001303507.2 NP_001290436.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 3
NM_002720.3 NP_002711.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9647778 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
18715871 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of double-strand break repair IMP
IMP: 通过突变表型推断
18614045 GOA
involved in regulation of double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
20154705 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
18614045 GOA
part of protein phosphatase 4 complex IPI
IPI: 通过物理相互作用推断
18614045 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP4C 蛋白结构

Metallophos

Metallophos: Calcineurin-like phosphoesterase (48 - 240)

  • 0
  • 100
  • 200
  • 307 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase 4 catalytic subunit

epididymis secretory sperm binding protein

PPP4C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Tag CoIP
16085932
种属内
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Tag CoIP
19156129
种属内
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Tag CoIP
18715871
种属内
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
TAP
16085932
种属内
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Bait CoIP
17353931
种属内
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Tag CoIP
33961781
种属内
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Tag CoIP
27880917
种属内
PPP4C P60510 TIPRL Homo sapiens O75663
Anti Tag CoIP
17384681
种属内
PPP4C P60510 TIPRL Homo sapiens O75663
Anti Tag CoIP
27880917
种属内
PPP4C P60510 TIPRL Homo sapiens O75663
Anti Tag CoIP
16085932
种属内
PPP4C P60510 TIPRL Homo sapiens O75663
Anti Bait CoIP
17353931
种属内
PPP4C P60510 IGBP1 Homo sapiens P78318
Anti Tag CoIP
18715871
种属内
PPP4C P60510 IGBP1 Homo sapiens P78318
Y2H
9647778
种属内
PPP4C P60510 IGBP1 Homo sapiens P78318
Y2H Array
32296183
种属内
PPP4C P60510 IGBP1 Homo sapiens P78318
TAP
16085932
种属内
PPP4C P60510 IGBP1 Homo sapiens P78318
Anti Tag CoIP
33961781
种属内
PPP4C P60510 IGBP1 Homo sapiens P78318
Anti Tag CoIP
19156129
种属内
PPP4C P60510 IGBP1 Homo sapiens P78318
Y2H Prey Pooling
32296183
种属内
PPP4C P60510 IGBP1 Homo sapiens P78318
Anti Tag CoIP
27880917
种属内
PPP4C P60510 IGBP1 Homo sapiens P78318
Anti Bait CoIP
18614045
种属内
PPP4C P60510 IGBP1 Homo sapiens P78318
Validated Y2H
32296183
种属内
PPP4C P60510 PPP4R1 Homo sapiens Q8TF05
Anti Tag CoIP
27880917
种属内
PPP4C P60510 PPP4R1 Homo sapiens Q8TF05
Anti Tag CoIP
18715871
种属内
PPP4C P60510 PPP4R1 Homo sapiens Q8TF05
TAP
16085932
种属内
PPP4C P60510 PPP4R1 Homo sapiens Q8TF05
Anti Tag CoIP
33961781
种属内
PPP4C P60510 PPP4R1 Homo sapiens Q8TF05
Anti Bait CoIP
17353931
种属内
PPP4C P60510 PTPA Homo sapiens Q15257
Anti Tag CoIP
33961781
种属内
PPP4C P60510 PPP4R4 Homo sapiens Q6NUP7
Anti Tag CoIP
27880917
种属内
PPP4C P60510 PPP4R4 Homo sapiens Q6NUP7
Anti Tag CoIP
18715871
种属内
PPP4C P60510 PPP4R4 Homo sapiens Q6NUP7
Anti Tag CoIP
33961781
种属内
PPP4C P60510 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
33961781
种属内
PPP4C P60510 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
19156129
种属内
PPP4C P60510 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
27880917
种属内
PPP4C P60510 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
18715871
种属内
PPP4C P60510 PPP2R1A Homo sapiens P30153
Anti Bait CoIP
17353931
种属内
PPP4C P60510 HDAC3 Homo sapiens O15379
Anti Tag CoIP
15805470
种属内
PPP4C P60510 HDAC3 Homo sapiens O15379
Pull Down
15805470
种属间: 跨种属相互作用 种属内: 同种属相互作用

PPP4C 抗体

目录号 产品名 应用 反应物种
HY-P80873 PPP4C Antibody (YA687) WB, IHC-F, IHC-P, ICC/IF Human

关联疾病

疾病名称 别名
Contagious Pustular Dermatitis

Ecthyma, Contagious

Orf

Ecthyma Contagiosum

Scabby Mouth

Sheep Pox

Thistle Disease

Contagious Pustular Dermatosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11028 PPP4C Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PPP4C VGNC VGNC:69022
Mus musculus PPP4C MGD MGI:1891763
Bos taurus PPP4C VGNC VGNC:33268
Macaca mulatta PPP4C VGNC VGNC:76384
Rattus norvegicus PPP4C RGD RGD:621225
Canis familiaris PPP4C VGNC VGNC:44921
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