1. Gene
  2. HDAC3 - histone deacetylase 3 Gene

HDAC3 - histone deacetylase 3 Gene

中文名称:组蛋白脱乙酰酶 3

种属: Homo sapiens

同用名: HD3; RPD3; KDAC3; RPD3-2

基因 ID: 8841 | 基因类型: protein coding

关于 HDAC3

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,620,881-141,636,849 (from NCBI)

This gene has 16 transcripts (splice variants), 155 orthologues and 10 paralogues. Ubiquitous expression in lymph node (RPKM 21.1), adrenal (RPKM 20.9) and 25 other tissues.

功能概要

组蛋白在转录调控、细胞周期进程和发育事件中发挥关键作用。组蛋白乙酰化/去乙酰化改变染色体结构并影响转录因子对 DNA 的访问。该基因编码的蛋白质属于组蛋白脱乙酰酶/acuc/apha 家族。它具有组蛋白脱乙酰酶活性,并在连接到启动子时抑制转录。它可能通过与锌指转录因子 YY1 结合参与转录调控。这种蛋白质还可以下调 p53 功能,从而调节细胞生长和凋亡。该基因被认为是潜在的肿瘤抑制基因。[RefSeq 提供,2008 年 7 月]

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and Apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

HDAC3 基因产物(10)

mRNA Protein Name
NR_149169.2
NM_001355041.2 NP_001341970.1 histone deacetylase 3 isoform 4
NR_149167.2
NM_001355040.2 NP_001341969.1 histone deacetylase 3 isoform 3
NR_149166.2
NR_149164.2
NM_003883.4 NP_003874.2 histone deacetylase 3 isoform 2
NR_149168.2
NR_149165.2
NM_001355039.2 NP_001341968.1 histone deacetylase 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NF-kappaB binding IPI
IPI: 通过物理相互作用推断
17785205 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
16569215 GOA
enables cyclin binding IPI
IPI: 通过物理相互作用推断
18417529 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
11641274 GOA
enables histone deacetylase activity IDA
IDA: 通过直接分析推断
28497810 GOA
enables histone deacetylase activity IMP
IMP: 通过突变表型推断
16924111 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
10869435 GOA
enables histone decrotonylase activity IDA
IDA: 通过直接分析推断
28497810 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11006275 GOA
enables protein de-2-hydroxyisobutyrylase activity IDA
IDA: 通过直接分析推断
29192674 GOA
enables protein decrotonylase activity IDA
IDA: 通过直接分析推断
34608293 GOA
enables protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
15653507 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
16569215 GOA
enables transcription corepressor activity IMP
IMP: 通过突变表型推断
12628926 GOA
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
10898795 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA repair-dependent chromatin remodeling IDA
IDA: 通过直接分析推断
25301942 GOA
involved in cellular response to fluid shear stress IDA
IDA: 通过直接分析推断
25190803 GOA
involved in establishment of mitotic spindle orientation IDA
IDA: 通过直接分析推断
34608293 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
16924111 GOA
involved in negative regulation of JNK cascade IMP
IMP: 通过突变表型推断
11931768 GOA
NOT involved in negative regulation of myotube differentiation IMP
IMP: 通过突变表型推断
10983972 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16569215 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
12628926 GOA
involved in positive regulation of TOR signaling IMP
IMP: 通过突变表型推断
25190803 GOA
involved in positive regulation of protein import into nucleus IDA
IDA: 通过直接分析推断
25190803 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
25190803 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
25190803 GOA
involved in protein deacetylation IDA
IDA: 通过直接分析推断
21030595 GOA
involved in regulation of protein stability IDA
IDA: 通过直接分析推断
25190803 GOA
involved in spindle assembly IMP
IMP: 通过突变表型推断
18326024 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
25190803 GOA
located in cytosol IDA
IDA: 通过直接分析推断
21030595 GOA
part of histone deacetylase complex IDA
IDA: 通过直接分析推断
18326024 GOA
located in mitotic spindle IDA
IDA: 通过直接分析推断
18326024 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18326024 GOA
part of transcription repressor complex IDA
IDA: 通过直接分析推断
11804585 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HDAC3 蛋白结构

Hist_deacetyl

Hist_deacetyl: Histone deacetylase domain (18 - 314)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
蛋白主名 其他名称

histone deacetylase 3

SMAP45

protein deacetylase HDAC3

protein deacylase HDAC3

HDAC3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HDAC3 O15379 AKAP8 Homo sapiens O43823 16980585
种属内
HDAC3 O15379 AKAP8 Homo sapiens O43823 16980585
种属内
HDAC3 O15379 AKAP8 Homo sapiens O43823 16980585
种属内
HDAC3 O15379 SUZ12 Homo sapiens Q15022 23079660
种属内
HDAC3 O15379 NCOR1 Homo sapiens O75376 23752268
种属内
HDAC3 O15379 NCOR1 Homo sapiens O75376 35271311
种属内
HDAC3 O15379 NCOR1 Homo sapiens O75376 11013263
种属内
HDAC3 O15379 NCOR1 Homo sapiens O75376 16980585
种属内
HDAC3 O15379 NCOR1 Homo sapiens O75376 21258344
种属间
HDAC3 O15379 Ncor1 Mus musculus Q60974 16917504
种属间
HDAC3 O15379 Ncor1 Mus musculus Q60974 17956988
种属内
HDAC3 O15379 AKAP8L Homo sapiens Q9ULX6 16980585
种属内
HDAC3 O15379 AKAP8L Homo sapiens Q9ULX6 16980585
种属内
HDAC3 O15379 MYC Homo sapiens P01106 23079660
种属内
HDAC3 O15379 MYC Homo sapiens P01106 23079660
种属内
HDAC3 O15379 MAGEA2 Homo sapiens P43356 16847267
种属内
HDAC3 O15379 PGK1 Homo sapiens P00558 26356530
种属内
HDAC3 O15379 PGK1 Homo sapiens P00558 26356530
种属内
HDAC3 O15379 KDM1A Homo sapiens O60341 23752268
种属内
HDAC3 O15379 KDM1A Homo sapiens O60341 23752268
种属内
HDAC3 O15379 KDM1A Homo sapiens O60341 21258344
种属内
HDAC3 O15379 GPS2 Homo sapiens Q13227 23752268
种属内
HDAC3 O15379 GPS2 Homo sapiens Q13227 21258344
种属内
HDAC3 O15379 GPS2 Homo sapiens Q13227 35271311
种属内
HDAC3 O15379 GPS2 Homo sapiens Q13227 16980585
种属内
HDAC3 O15379 L3MBTL2 Homo sapiens Q969R5
IF
20385135
种属内
HDAC3 O15379 L3MBTL2 Homo sapiens Q969R5 20385135
种属内
HDAC3 O15379 APPL1 Homo sapiens Q9UKG1 23752268
种属内
HDAC3 O15379 APPL1 Homo sapiens Q9UKG1 23752268
种属内
HDAC3 O15379 NRIP1 Homo sapiens P48552
Y2H
17053781
种属内
HDAC3 O15379 NRIP1 Homo sapiens P48552 17053781
种属内
HDAC3 O15379 NCOR2 Homo sapiens Q9Y618 22230954
种属内
HDAC3 O15379 NCOR2 Homo sapiens Q9Y618 22230954
种属内
HDAC3 O15379 NCOR2 Homo sapiens Q9Y618 21624135
种属内
HDAC3 O15379 NCOR2 Homo sapiens Q9Y618 21258344
种属内
HDAC3 O15379 NCOR2 Homo sapiens Q9Y618 16980585
种属内
HDAC3 O15379 NCOR2 Homo sapiens Q9Y618 22230954
种属内
HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
GMS
22230954
种属内
HDAC3 O15379 NCOR2 Homo sapiens Q9Y618 23752268
种属内
HDAC3 O15379 NCOR2 Homo sapiens Q9Y618 35271311
种属内
HDAC3 O15379 NCOR2 Homo sapiens Q9Y618 16980585
种属内
HDAC3 O15379 NCOR2 Homo sapiens Q9Y618 16924111
种属内
HDAC3 O15379 MBD1 Homo sapiens Q9UIS9 16432238
种属间
HDAC3 O15379 ICP0 Human herpesvirus 1 P08393 15194749
种属间
HDAC3 O15379 ICP0 Human herpesvirus 1 P08393 15194749
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures

OPA10

Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures

Optic Atrophy 10

Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures

Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Rett Syndrome

Atypical Rett Syndrome

RTT

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Atypical

Rett Syndrome, Preserved Speech Variant

Rett'S Disorder

Rett Syndrome Variant

Rett Disorder

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus HDAC3 VGNC VGNC:67549
Canis familiaris HDAC3 VGNC VGNC:50628
Rattus norvegicus HDAC3 RGD RGD:619977
Mus musculus HDAC3 MGD MGI:1343091
Bos taurus HDAC3 VGNC VGNC:106764
Macaca mulatta HDAC3 VGNC VGNC:73359
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