2. Gene
  3. NCOR2 - nuclear receptor corepressor 2 Gene

NCOR2 - nuclear receptor corepressor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核受体辅阻遏物 2

种属: Homo sapiens

同用名: SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau

基因 ID: 9612 | 基因类型: protein coding

关于 NCOR2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:124,324,415-124,567,612 (from NCBI)

This gene has 24 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 94 phenotypes. Ubiquitous expression in fat (RPKM 14.9), lung (RPKM 14.3) and 25 other tissues.

功能概要

该基因编码介导某些靶基因转录沉默的核受体共阻遏物。编码的蛋白质是甲状腺激素和视黄酸受体相关共抑制因子家族的成员。这种蛋白质作为多亚基复合物的一部分，其中包括组蛋白脱乙酰酶以修饰染色质结构，从而阻止靶基因的基础转录活性。该基因的异常表达与某些癌症有关。交替剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 4 月]

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

NCOR2 基因产物(3)

mRNA Protein Name
NM_001077261.4 NP_001070729.2 nuclear receptor corepressor 2 isoform 2
NM_001206654.2 NP_001193583.1 nuclear receptor corepressor 2 isoform 3
NM_006312.6 NP_006303.4 nuclear receptor corepressor 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Notch binding IPI
IPI: 通过物理相互作用推断
10713164 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
11804585 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9605924 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
18052923 GOA
enables transcription corepressor activity IMP
IMP: 通过突变表型推断
12628926 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
20812024 GOA
involved in negative regulation of androgen receptor signaling pathway IMP
IMP: 通过突变表型推断
20812024 GOA
involved in negative regulation of miRNA transcription IMP
IMP: 通过突变表型推断
20388878 GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10097068 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
12628926 GOA
involved in regulation of cellular ketone metabolic process IMP
IMP: 通过突变表型推断
19955185 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
20388878 GOA
located in nuclear body IDA
IDA: 通过直接分析推断
16030140 GOA
located in nuclear matrix IDA
IDA: 通过直接分析推断
21328542 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10097068 GOA
part of transcription repressor complex IDA
IDA: 通过直接分析推断
11804585 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCOR2 蛋白结构

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (613 - 657)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2514 a.a.
蛋白主名 其他名称

nuclear receptor corepressor 2

CTG repeat protein 26

NCOR2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NCOR2 Q9Y618 TBL1X Homo sapiens O60907-2
Pull Down
21240272
Intra NCOR2 Q9Y618 HDAC1 Homo sapiens Q13547
Affinity Chrom
11013263
Intra NCOR2 Q9Y618 TP53 Homo sapiens P04637
Competition Binding
24449765
Intra NCOR2 Q9Y618 TP53 Homo sapiens P04637
Pull Down
24449765
Intra NCOR2 Q9Y618 THRB Homo sapiens P10828-1
EMSA
9605924
Intra NCOR2 Q9Y618 THRB Homo sapiens P10828-1
Pull Down
9605924
Intra NCOR2 Q9Y618 E2F1 Homo sapiens Q01094
TAP
20195357
Intra NCOR2 Q9Y618 E2F1 Homo sapiens Q01094
Display Tech
20195357
Intra NCOR2 Q9Y618 HDAC3 Homo sapiens O15379
Competition Binding
24449765
Intra NCOR2 Q9Y618 HDAC3 Homo sapiens O15379
Affinity Chrom
11013263
Intra NCOR2 Q9Y618 RBPJ Homo sapiens Q06330
Y2H
21475249
Intra NCOR2 Q9Y618 RBPJ Homo sapiens Q06330
Y2H
10713164
Intra NCOR2 Q9Y618 SNW1 Homo sapiens Q13573
Y2H
14985122
Intra NCOR2 Q9Y618 SNW1 Homo sapiens Q13573
Y2H
10713164
Intra NCOR2 Q9Y618 GPS2 Homo sapiens Q13227
Pull Down
21240272
Intra NCOR2 Q9Y618 AHR Homo sapiens P35869
CoIP
10395741
Intra NCOR2 Q9Y618 ARNT Homo sapiens P27540
CoIP
10395741
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Plasma Cell Neoplasm

Plasma Cell Dyscrasia

Paraproteinemias

Plasma Cell Tumour

Plasmacytic Tumor

Multiple Myeloma

Plasmacytoma

Plasma Cell Tumours

Plasma Cells Dyscrasia
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Clubfoot

Congenital Talipes Equinovarus

Congenital Clubfoot

Congenital Equinovarus

Equinovarus Deformity Of Foot

Club Foot
Rett Syndrome

Atypical Rett Syndrome

RTT

Rett Disorder

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Preserved Speech Variant

Rett Syndrome, Atypical

Rett'S Disorder

Rett Syndrome Variant

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant
Thrombophilia, X-Linked, Due To Factor Ix Defect

THPH8

Deep Venous Thrombosis, Protection Against

X-Linked Thrombophilia Due To Factor Ix Defect

Thrombophilia, X-Linked, Due To Factor 9 Defect

Thrombophilia 8, X-Linked, Due To Factor Ix Defect
Retinitis Pigmentosa 90

RP90

Retinitis Pigmentosa, Type 90
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09097 NCOR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NCOR2 VGNC VGNC:52954
Mus musculus NCOR2 MGD MGI:1337080
Macaca mulatta NCOR2 VGNC VGNC:75148
Bos taurus NCOR2 VGNC VGNC:58394
Rattus norvegicus NCOR2 RGD RGD:1310293
Felis catus NCOR2 VGNC VGNC:80458
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