2. Gene
  3. ARNT - aryl hydrocarbon receptor nuclear translocator Gene

ARNT - aryl hydrocarbon receptor nuclear translocator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：芳烃受体核转位子

种属: Homo sapiens

同用名: HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta

基因 ID: 405 | 基因类型: protein coding

关于 ARNT

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,809,713-150,876,599 (from NCBI)

This gene has 12 transcripts (splice variants), 212 orthologues, 6 paralogues and is associated with 69 phenotypes. Ubiquitous expression in ovary (RPKM 16.9), placenta (RPKM 14.7) and 25 other tissues.

功能概要

该基因编码的蛋白质包含一个基本的螺旋-环-螺旋结构域和两个特征性 PAS 结构域以及一个 PAC 结构域。编码的蛋白质与配体结合的芳基烃受体结合，并帮助该复合物移动到细胞核，在那里它促进参与异生物质代谢的基因的表达。该蛋白也是缺氧诱导因子 1 转录调控的辅助因子。该基因座与 12 号染色体上的 ETV6 (ets 变体 6) 基因的染色体易位已在白血病中得到描述。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 10 月]

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound Aryl Hydrocarbon Receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

ARNT 基因产物(8)

mRNA Protein Name
NM_001197325.2 NP_001184254.1 aryl hydrocarbon receptor nuclear translocator isoform 4
NM_001286035.2 NP_001272964.1 aryl hydrocarbon receptor nuclear translocator isoform 5
NM_001286036.2 NP_001272965.1 aryl hydrocarbon receptor nuclear translocator isoform 6
NM_001350224.2 NP_001337153.1 aryl hydrocarbon receptor nuclear translocator isoform 7
NM_001350225.2 NP_001337154.1 aryl hydrocarbon receptor nuclear translocator isoform 8
NM_001350226.2 NP_001337155.1 aryl hydrocarbon receptor nuclear translocator isoform 9
NM_001668.4 NP_001659.1 aryl hydrocarbon receptor nuclear translocator isoform 1
NM_178427.3 NP_848514.1 aryl hydrocarbon receptor nuclear translocator isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
29454749 GOA
contributes to DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
7539918 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
7539918 GOA
enables aryl hydrocarbon receptor binding IPI
IPI: 通过物理相互作用推断
9079689 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23275542 GOA
contributes to nuclear receptor activity IDA
IDA: 通过直接分析推断
34521881 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10395741 GOA
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
16181639 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
9079689 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
16181639 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
7539918 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28396409 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of inflammatory response IDA
IDA: 通过直接分析推断
29454749 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7539918 GOA
involved in positive regulation of vascular endothelial growth factor production IDA
IDA: 通过直接分析推断
8756616 GOA
involved in response to hypoxia IDA
IDA: 通过直接分析推断
8756616 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
7539918 GOA
part of nuclear aryl hydrocarbon receptor complex IDA
IDA: 通过直接分析推断
34521881 GOA
located in nucleus IDA
IDA: 通过直接分析推断
34521881 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARNT 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (91 - 142)

PAS

PAS: PAS fold (166 - 269)

PAS_11

PAS_11: PAS domain (362 - 465)

  • 0
  • 200
  • 400
  • 600
  • 789 a.a.
蛋白主名 其他名称

aryl hydrocarbon receptor nuclear translocator

class E basic helix-loop-helix protein 2

ARNT 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ARNT P27540 HIF1A Homo sapiens Q16665
Anti Bait CoIP
20932347
Intra ARNT P27540 HIF1A Homo sapiens Q16665
NMR
14668441
Intra ARNT P27540 HIF1A Homo sapiens Q16665
Y2H
9704006
Intra ARNT P27540 EPAS1 Homo sapiens Q99814
Y2H
11018023
Intra ARNT P27540 EPAS1 Homo sapiens Q99814
NMR
14668441
Intra ARNT P27540 AHR Homo sapiens P35869
Anti Tag CoIP
33961781
Intra ARNT P27540 AHR Homo sapiens P35869
Anti Tag CoIP
28514442
Intra ARNT P27540 AHR Homo sapiens P35869
CoIP
10395741
Intra ARNT P27540 NCOA7 Homo sapiens Q8NI08
CoIP
10395741
Intra ARNT P27540 NCOR2 Homo sapiens Q9Y618
CoIP
10395741
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia
Esophagus Carcinoma In Situ

Carcinoma In Situ Of Esophagus

Carcinoma In Situ Of Oesophagus

Oesophagus Carcinoma In Situ

Severe Esophageal Dysplasia

Stage 0 Carcinoma Of The Esophagus

Stage 0 Carcinoma Of The Oesophagus

Severe Oesophageal Dysplasia
Primary Polycythemia

Familial Erythrocytosis

Familiar Polycythemia

Benign Familial Polycythemia

Congenital Erythrocytosis

Familial Polycythemia

Hereditary Erythrocytosis

Primary Familial Polycythemia

Erythrocytosis, Familial

Polycythemia Vera

Primary Familial Polycythaemia

Primary Inherited Polycythaemia
Erythrocytosis, Familial, 2

Chuvash Polycythemia

ECYT2

Familial Erythrocytosis 2

Autosomal Recessive Benign Erythrocytosis

Polycythemia, Vhl-Dependent

Chuvash Erythromatosis

Chuvash Type Polycythemia

Chuvash Erythrocytosis

Von Hippel-Lindau-Dependent Polycythemia

Polycythemia Chuvash Type

Vhl-Dependent Polycythemia

Erythrocytosis, Familial, Type 2
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity

Retrolental Fibroplasia

EVR1

Criswick-Schepens Syndrome

Rop

Exudative Vitreoretinopathy, Familial, Autosomal Dominant

Fevr, Autosomal Dominant

Premature Retinopathy

Vitreoretinopathy, Exudative 1

Autosomal Dominant Familial Exudative Vitreoretinopathy

Fevr

Vitreoretinopathy, Exudative, Type 1

Retinopathy Of Prematurity Nos

Rlf- [Retrolental Fibroplasia]

Rop - [Retinopathy Of Prematurity]

Terry Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120087 KG-548 Inhibitor 99.92% 否
HY-RS01011 ARNT Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-112374 NPAS3-IN-1 98.29% 否
HY-W012248 KG-655 Modulator 99.87% 否
HY-P10090 Apoptin-derived peptide / 否
HY-RS01012 ARNT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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