NCOA7 - nuclear receptor coactivator 7 Gene

中文名称：核受体共激活因子 7

种属: Homo sapiens

同用名: ESNA1; TLDC4; ERAP140; NCOA7-AS; Nbla00052; Nbla10993; dJ187J11.3

基因 ID: 135112 | 基因类型: protein coding

关于 NCOA7

Cytogenetic location: 6q22.31-q22.32 Genomic coordinates (GRCh38): 6:125,781,115-125,932,034 (from NCBI)

This gene has 11 transcripts (splice variants), 295 orthologues and 3 paralogues. Ubiquitous expression in urinary bladder (RPKM 17.8), adrenal (RPKM 16.0) and 25 other tissues.

功能概要

启用核受体结合活性和核受体共激活因子活性。参与 RNA 聚合酶 II 对转录的正调控。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Enables nuclear receptor binding activity and nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NCOA7 基因产物(6)

mRNA	Protein	Name
NM_001122842.3	NP_001116314.1	nuclear receptor coactivator 7 isoform 2
NM_001199619.2	NP_001186548.1	nuclear receptor coactivator 7 isoform 1
NM_001199620.2	NP_001186549.1	nuclear receptor coactivator 7 isoform 1
NM_001199621.2	NP_001186550.1	nuclear receptor coactivator 7 isoform 3
NM_001199622.2	NP_001186551.1	nuclear receptor coactivator 7 isoform 4
NM_181782.5	NP_861447.3	nuclear receptor coactivator 7 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables nuclear receptor binding	IDA IDA: 通过直接分析推断	11971969	GOA
enables nuclear receptor coactivator activity	IDA IDA: 通过直接分析推断	11971969	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10395741	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	11971969	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCOA7 蛋白结构

LysM

TLD

0
200
400
600
800
942 a.a.

蛋白主名

其他名称

nuclear receptor coactivator 7

140 kDa estrogen receptor-associated protein

NCOA7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NCOA7	Q8NI08	DIRAS1	Homo sapiens	O95057	Anti Tag CoIP	33961781
种属内	NCOA7	Q8NI08	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
种属内	NCOA7	Q8NI08	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
种属内	NCOA7	Q8NI08	GABARAP	Homo sapiens	O95166	Pull Down	20562859
种属内	NCOA7	Q8NI08	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
种属内	NCOA7	Q8NI08	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome

Door Syndrome	Doors Syndrome
Digitorenocerebral Syndrome	Autosomal Recessive Deafness-Onychodystrophy Syndrome
Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome	DOORS
Drc Syndrome	Eronen Syndrome
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Brachydactyly Due To Absence Of Distal Phalanges
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome	Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome
Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome
Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome
Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome	Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome
Deafness, Congenital Onychodystrophy, Recessive Form	Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome

Developmental And Epileptic Encephalopathy 16

DEE16	Epileptic Encephalopathy, Early Infantile, 16
Eiee16	Developmental And Epileptic Encephalopathy, 16
Early Infantile Epileptic Encephalopathy 16	Progressive Myoclonic Epilepsy With Dystonia
Pmed	Progressive Myoclonus Epilepsy With Dystonia
Encephalopathy, Epileptic, Early Infantile, Type 16

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Martsolf Syndrome 1

Martsolf Syndrome	Cataract-Intellectual Disability-Hypogonadism Syndrome
MARTS1	Marts
Cataract-Mental Retardation-Hypogonadism	Martsolf

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09095	NCOA7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NCOA7	RGD	RGD:1566426
Felis catus	NCOA7	VGNC	VGNC:63743
Macaca mulatta	NCOA7	VGNC	VGNC:74998
Mus musculus	NCOA7	MGD	MGI:2444847
Canis familiaris	NCOA7	VGNC	VGNC:43664
Bos taurus	NCOA7	VGNC	VGNC:108132

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