1. Gene
  2. AHR - aryl hydrocarbon receptor Gene

AHR - aryl hydrocarbon receptor Gene

中文名称:芳烃受体

种属: Homo sapiens

同用名: RP85; bHLHe76

基因 ID: 196 | 基因类型: protein coding

关于 AHR

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:17,298,652-17,346,147 (from NCBI)

This gene has 7 transcripts (splice variants), 151 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in urinary bladder (RPKM 37.2), gall bladder (RPKM 28.4) and 24 other tissues.

功能概要

该基因编码的蛋白质是配体激活的螺旋-环-螺旋转录因子,参与平面芳烃生物反应的调节。该受体已被证明可以调节异生素代谢酶,例如细胞色素 P450。在配体结合之前,编码的蛋白质被隔离在细胞质中;在配体结合后,该蛋白质移动到细胞核并刺激靶基因的转录。[RefSeq 提供,2015 年 9 月]

The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing Enzymes such as Cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]

AHR 基因产物(1)

mRNA Protein Name
NM_001621.5 NP_001612.1 aryl hydrocarbon receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15681594 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
11782478 GOA
enables Hsp90 protein binding IDA
IDA: 通过直接分析推断
9079689 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
9079689 GOA
enables TBP-class protein binding IPI
IPI: 通过物理相互作用推断
15641800 GOA
enables TFIID-class transcription factor complex binding IPI
IPI: 通过物理相互作用推断
15641800 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23275542 GOA
contributes to nuclear receptor activity IDA
IDA: 通过直接分析推断
34521881 GOA
enables nuclear receptor activity IDA
IDA: 通过直接分析推断
10395741 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9079689 GOA
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
28602820 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28602820 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
15681594 GOA
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
15641800 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cAMP-mediated signaling IDA
IDA: 通过直接分析推断
17329248 GOA
involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine IDA
IDA: 通过直接分析推断
17329248 GOA
involved in cellular response to cAMP IDA
IDA: 通过直接分析推断
17329248 GOA
involved in cellular response to forskolin IDA
IDA: 通过直接分析推断
17329248 GOA
involved in cellular response to molecule of bacterial origin IDA
IDA: 通过直接分析推断
29454749 GOA
involved in negative regulation of T cell mediated immune response to tumor cell IDA
IDA: 通过直接分析推断
32818467 GOA
involved in negative regulation of inflammatory response IDA
IDA: 通过直接分析推断
29454749 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
32818467 GOA
involved in regulation of B cell proliferation IDA
IDA: 通过直接分析推断
15681594 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10395741 GOA
involved in regulation of adaptive immune response IDA
IDA: 通过直接分析推断
32818467 GOA
involved in regulation of gene expression IDA
IDA: 通过直接分析推断
15681594 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15681594 GOA
involved in response to toxic substance IDA
IDA: 通过直接分析推断
7961644 GOA
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
7961644 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15681594 GOA
located in cytosol IDA
IDA: 通过直接分析推断
17329248 GOA
part of nuclear aryl hydrocarbon receptor complex IDA
IDA: 通过直接分析推断
34521881 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
28602820 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10395741 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
15641800 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AHR 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (37 - 78)

PAS

PAS: PAS fold (114 - 226)

PAS_3

PAS_3: PAS fold (300 - 382)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 848 a.a.
蛋白主名 其他名称

aryl hydrocarbon receptor

AH-receptor

AHR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AHR P35869 NCOA7 Homo sapiens Q8NI08
CoIP
10395741
种属内
AHR P35869 ARNT Homo sapiens P27540
Y2H
9704006
种属内
AHR P35869 ARNT Homo sapiens P27540
CoIP
10395741
种属内
AHR P35869 NCOR2 Homo sapiens Q9Y618
CoIP
10395741
种属间
AHR P35869 EBNA3 Epstein-Barr virus P12977
IF
16257957
种属间
AHR P35869 EBNA3 Epstein-Barr virus P12977
Pull Down
16257957
种属间
AHR P35869 EBNA3 Epstein-Barr virus P12977
Anti Tag CoIP
16257957
种属间: 跨种属相互作用 种属内: 同种属相互作用

AHR 抗体

目录号 产品名 应用 反应物种
HY-P80378 AHR Antibody WB, ICC/IF Human
HY-P82417 Aryl Hydrocarbon Receptor Antibody (YA2162) WB Human

关联疾病

疾病名称 别名
Retinitis Pigmentosa 85

RP85

Retinitis Pigmentosa, Type 85

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Aryl Hydrocarbon Hydroxylase Inducibility

Ahh Inducibility

Ahhi

Eosinophilia-Myalgia Syndrome

Eosinophilia Myalgia Syndrome

Ems

L-Tryptophan Induced Ems

Severe Muscle Pain And Abnormally High Eosinophils

Syndrome With Inflammatory And Autoimmune Components That Affect The Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, And Heart

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Penis Agenesis

Micropenis

Agenesis Of The Penis

Penis Agenesia

Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris AHR VGNC VGNC:54752
Rattus norvegicus AHR RGD RGD:2074
Mus musculus AHR MGD MGI:105043