2. Gene
  3. AHR - aryl hydrocarbon receptor Gene

AHR - aryl hydrocarbon receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：芳烃受体

种属: Homo sapiens

同用名: RP85; bHLHe76

基因 ID: 196 | 基因类型: protein coding

关于 AHR

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:17,298,652-17,346,147 (from NCBI)

This gene has 7 transcripts (splice variants), 151 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in urinary bladder (RPKM 37.2), gall bladder (RPKM 28.4) and 24 other tissues.

功能概要

该基因编码的蛋白质是配体激活的螺旋-环-螺旋转录因子，参与平面芳烃生物反应的调节。该受体已被证明可以调节异生素代谢酶，例如细胞色素 P450。在配体结合之前，编码的蛋白质被隔离在细胞质中；在配体结合后，该蛋白质移动到细胞核并刺激靶基因的转录。[RefSeq 提供，2015 年 9 月]

The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing Enzymes such as Cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]

AHR 基因产物(1)

mRNA Protein Name
NM_001621.5 NP_001612.1 aryl hydrocarbon receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15681594 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
11782478 GOA
enables Hsp90 protein binding IDA
IDA: 通过直接分析推断
9079689 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
9079689 GOA
enables TBP-class protein binding IPI
IPI: 通过物理相互作用推断
15641800 GOA
enables TFIID-class transcription factor complex binding IPI
IPI: 通过物理相互作用推断
15641800 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23275542 GOA
contributes to nuclear receptor activity IDA
IDA: 通过直接分析推断
34521881 GOA
enables nuclear receptor activity IDA
IDA: 通过直接分析推断
10395741 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9079689 GOA
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
28602820 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28602820 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
15681594 GOA
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
15641800 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cAMP-mediated signaling IDA
IDA: 通过直接分析推断
17329248 GOA
involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine IDA
IDA: 通过直接分析推断
17329248 GOA
involved in cellular response to cAMP IDA
IDA: 通过直接分析推断
17329248 GOA
involved in cellular response to forskolin IDA
IDA: 通过直接分析推断
17329248 GOA
involved in cellular response to molecule of bacterial origin IDA
IDA: 通过直接分析推断
29454749 GOA
involved in negative regulation of T cell mediated immune response to tumor cell IDA
IDA: 通过直接分析推断
32818467 GOA
involved in negative regulation of inflammatory response IDA
IDA: 通过直接分析推断
29454749 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
32818467 GOA
involved in regulation of B cell proliferation IDA
IDA: 通过直接分析推断
15681594 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10395741 GOA
involved in regulation of adaptive immune response IDA
IDA: 通过直接分析推断
32818467 GOA
involved in regulation of gene expression IDA
IDA: 通过直接分析推断
15681594 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15681594 GOA
involved in response to toxic substance IDA
IDA: 通过直接分析推断
7961644 GOA
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
7961644 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15681594 GOA
located in cytosol IDA
IDA: 通过直接分析推断
17329248 GOA
part of nuclear aryl hydrocarbon receptor complex IDA
IDA: 通过直接分析推断
34521881 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
28602820 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10395741 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
15641800 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AHR 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (37 - 78)

PAS

PAS: PAS fold (114 - 226)

PAS_3

PAS_3: PAS fold (300 - 382)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 848 a.a.
蛋白主名 其他名称

aryl hydrocarbon receptor

AH-receptor

AHR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra AHR P35869 NCOA7 Homo sapiens Q8NI08
CoIP
10395741
Intra AHR P35869 ARNT Homo sapiens P27540
Y2H
9704006
Intra AHR P35869 ARNT Homo sapiens P27540
CoIP
10395741
Intra AHR P35869 NCOR2 Homo sapiens Q9Y618
CoIP
10395741
Cross AHR P35869 EBNA3 Epstein-Barr virus P12977
IF
16257957
Cross AHR P35869 EBNA3 Epstein-Barr virus P12977
Pull Down
16257957
Cross AHR P35869 EBNA3 Epstein-Barr virus P12977
Anti Tag CoIP
16257957
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 85

RP85

Retinitis Pigmentosa, Type 85
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Aryl Hydrocarbon Hydroxylase Inducibility

Ahh Inducibility

Ahhi
Eosinophilia-Myalgia Syndrome

Eosinophilia Myalgia Syndrome

Ems

L-Tryptophan Induced Ems

Severe Muscle Pain And Abnormally High Eosinophils

Syndrome With Inflammatory And Autoimmune Components That Affect The Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, And Heart
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Penis Agenesis

Micropenis

Agenesis Of The Penis

Penis Agenesia
Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (11)
目录号 产品名 作用方式
纯度 是否罕见病
HY-109044 Tapinarof Agonist 99.95% 否
HY-N0178 Diosmin Agonist 99.51% 是
HY-A0083 Methacholine chloride Agonist ≥98.0% 是
HY-B0311 Carbidopa Modulator ≥98.0% 是
HY-B0678 Metaxalone 99.77% 否
HY-17357 Nepafenac Inhibitor 99.51% 否
HY-W017113 2-Mercaptobenzothiazole Activator 99.85% 是
HY-B0311A Carbidopa monohydrate Modulator ≥98.0% 是
HY-A0083B Methacholine bromide Agonist / 否
HY-B0678R Metaxalone (Standard) / 否
HY-17479 Amfenac / 否
Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-N0170 Indole-3-carbinol 98.87% Phase 3
HY-15001 Stemregenin 1 Antagonist 99.95% Phase 2
HY-16031 AFP464 free base Inhibitor / Phase 2
HY-111449 BAY-218 Antagonist 99.95% Phase 1
Pre-clinical Phase
生物活性分子 (113)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12028 PD98059 99.96% 否
HY-12684 CH-223191 Antagonist 99.96% 否
HY-15484 Pifithrin-α hydrobromide 98.05% 否
HY-12451 FICZ Agonist 99.42% 否
HY-W028393 Indole-3-pyruvic acid Agonist 99.79% 否
HY-19317 ITE Agonist 99.27% 否
HY-135829 BAY 2416964 Antagonist 99.59% 否
HY-W007355 Skatole 99.97% 否
HY-102023 GNF351 Antagonist 99.90% 否
HY-W015273A trans-3-Indoleacrylic acid Inhibitor 99.45% 否
HY-135750 VAF347 Agonist 99.90% 否
HY-114740 β-Naphthoflavone 99.95% 否
HY-122208 SGA360 Inhibitor 99.52% 否
HY-103220 6,2',4'-Trimethoxyflavone Antagonist 98.09% 否
HY-134217 KYN-101 Inhibitor 98.17% 否
HY-112629 PDM2 Antagonist 98.76% 否
HY-W014502 D-Kynurenine Agonist 99.67% 否
HY-W011338 Benzyl butyl phthalate Activator ≥97.0% 否
HY-144339 AhR agonist 2 99.53% 否
HY-119019 ASB14780 Inhibitor 99.83% 否
HY-18619 YL-109 Modulator 99.26% 否
HY-112627 CAY 10465 Agonist 98.30% 否
HY-B0845 Prochloraz 99.77% 否
HY-103221 MeBIO ≥98.0% 否
HY-135831 AHR antagonist 2 Antagonist 99.91% 否
HY-141609 AHR antagonist 5 free base Inhibitor 99.56% 否
HY-112628 CAY10464 Antagonist 99.77% 否
HY-118438 10-Cl-BBQ Agonist 99.48% 否
HY-N4095 Brevifolincarboxylic acid Inhibitor 99.90% 否
HY-136220 AHR antagonist 5 Antagonist 98.05% 否
HY-124421 5F-203 Inducer 99.04% 否
HY-105791 Sulazepam 99.56% 否
HY-117102 ANI-7 Activator 98.13% 否
HY-130256 β-NF-JQ1 Inhibitor 99.37% 否
HY-100242 Mivotilate Activator 99.58% 否
HY-103223 Phortress Inducer 99.25% 否
HY-111441 1,4-Chrysenequinone Activator 98.42% 否
HY-118780 CHD-5 Antagonist ≥98.0% 否
HY-12545 Brevetoxin-3 Activator ≥95.0% 否
HY-17357S Nepafenac-d5 Inhibitor 98.84% 否
HY-N6264 26-Deoxyactein Inhibitor 99.76% 否
HY-111450 CB7993113 Antagonist ≥98.0% 否
HY-125019 iJak-381 Inhibitor 99.86% 否
HY-N0586 Norisoboldine Agonist / 否
HY-N10123 Indolokine A5 Agonist ≥98.0% 否
HY-W014701 1,4-Dihydroxy-2-naphthoic acid Activator 99.58% 否
HY-W718300 Indole-3-pyruvic acid-d5 95.00% 否
HY-77278 25-Hydroxytachysterol3 Agonist 98.89% 否
HY-104026CS L-Kynurenine-13C10 sulfate hemihydrate Agonist 99.90% 否
HY-15001G Stemregenin 1 (GMP) Antagonist / 否
HY-16031B AFP464 dihydrochloride Inhibitor 99.67% 否
HY-N0586A Norisoboldine hydrochloride Agonist 99.72% 否
HY-RS00483 AHR Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-131340 LASSBio-1632 Inhibitor / 否
HY-136220A AHR antagonist 5 hemimaleate Antagonist / 否
HY-103222 DiMNF Modulator 98.01% 否
HY-104026B L-Kynurenine sulfate Agonist / 否
HY-106487 Pridefine / 否
HY-111157 Dezinamide / 否
HY-114682 Lenperone 97.26% 否
HY-114682A Lenperone hydrochloride Antagonist / 否
HY-116638 AHR-5333 Inhibitor / 否
HY-116638A AHR-5333 (mandelate) Inhibitor / 否
HY-117532 PenCB Inducer 99.94% 否
HY-117774 AHR-2244 hydrochloride / 否
HY-118792 AHR activator 1 / 否
HY-119960 AHR-10037 Inhibitor / 否
HY-120677 AHR-15010 Inhibitor / 否
HY-123461 Sul-121 hydrochloride / 否
HY-125926S 2-Ketodoxapram-d5 / 否
HY-129305 Tampramine fumarate Inhibitor / 否
HY-130269 β-Naphthoflavone-CH2-OH / 否
HY-130270 AhR Ligand-Linker Conjugates 1 / 否
HY-130842 β-Naphthoflavone-CH2-Br / 否
HY-135671 AhR modulator-1 / 否
HY-135830 AHR antagonist 4 Antagonist / 否
HY-155505 AHR agonist 4 Agonist / 否
HY-156908 3-OH-Kynurenamine Activator / 否
HY-158167 AhR agonist 5 / 否
HY-158168 AhR agonist 6 Agonist / 否
HY-158169 AhR agonist 7 Agonist / 否
HY-161649 hCYP1B1-IN-2 Inhibitor / 否
HY-168033 AhR agonist 8 Agonist / 否
HY-19826 Isofistularin-3 / 否
HY-A0083C Methacholine iodide Agonist / 否
HY-B0311AS Carbidopa-d3 monohydrate Modulator ≥98.0% 否
HY-B0311D Carbidopa hydrochloride Modulator / 否
HY-B0311S1 Carbidopa-d3-1 Modulator / 否
HY-B0678S Metaxalone-d3 ≥98.0% 否
HY-B0678S1 Metaxalone-d6 / 否
HY-N12537A (2R,3S)-PD-1/PD-L1-IN-38 / 否
HY-W011338S Benzyl butyl phthalate-d4 / 否
HY-W014502R D-Kynurenine (Standard) Agonist / 否
HY-W338764 AHR agonist 3 / 否
HY-101745 Rocastine Antagonist / 否
HY-101802 Fluzinamide / 否
HY-104026BS L-Kynurenine-13C10 sulfate Agonist / 否
HY-107063 AHR-1911 / 否
HY-116148 AHR-11797 / 否
HY-118910 AHR-14310C Antagonist / 否
HY-119018 AHR-6293 / 否
HY-119991 AHR-9294 Inhibitor / 否
HY-120377 CYP1A1 inhibitor 8a / 否
HY-123432 AHR-13268D / 否
HY-124021 Benzyl 2-naphthyl ether / 否
HY-125926S1 2-Ketodoxapram-d4 / 否
HY-128229 AHR antagonist 6 Antagonist / 否
HY-130456 AHR 10718 / 否
HY-136891 AHR-16303B / 否
HY-163665 AHR antagonist 8 Modulator / 否
HY-17479B Amfenac sodium / 否
HY-U00010 Dazopride / 否
HY-W764758 3-OH-Kynurenamine dihydroiodide Activator / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris AHR VGNC VGNC:54752
Rattus norvegicus AHR RGD RGD:2074
Mus musculus AHR MGD MGI:105043
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