2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Cytochrome P450 Aryl Hydrocarbon Receptor
  4. hCYP1B1-IN-2

hCYP1B1-IN-2 (compound 3n) 是一种有效的人细胞色素P450 1B1酶 hCYP1B1 抑制剂。hCYP1B1-IN-2 显示出有效的抗 hCYP1B1 活性(IC50=0.040 nM)，还可阻断 AhR 转录活性。hCYP1B1-IN-2 通过混合抑制方式有效抑制 hCYP1B1，其 Ki 值为 21.71 pM。

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hCYP1B1-IN-2 Chemical Structure

hCYP1B1-IN-2 Chemical Structure

CAS No. : 3043683-33-3

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hCYP1B1-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCYP1B1-IN-2 (compound 3n) is a potent human cytochrome P450 1B1 enzyme hCYP1B1 inhibitor. hCYP1B1-IN-2 shows the extremely potent anti-hCYP1B1 activity (IC50=0.040 nM) and blocks AhR transcription activity. hCYP1B1-IN-2 potently inhibits hCYP1B1 via a mix inhibition manner, showing a Ki value of 21.71 pM[1].

IC50 & Target

CYP1B1

0.040 nM (IC50)

CYP1A1

0.38 nM (IC50)

体外研究
(In Vitro)

hCYP1B1-IN-2 (compound 3n) (5 μM) 可以显著逆转 H460/PTX 细胞中的紫杉醇（PTX、HY-B0015）耐药性，其证据是 IC50 值从 632.6 nM（单独使用 PTX）降至 100.8 nM（PTX 加 3n）[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hCYP1B1-IN-2 相关抗体:
分子量

368.18

Formula

C17H10BrN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCYP1B1-IN-2 相关分类

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Keywords:

hCYP1B1-IN-23043683-33-3Cytochrome P450Aryl Hydrocarbon ReceptorCYPsAhRH460Inhibitorinhibitorinhibit

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