2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor
  4. DiMNF

DiMNF  (Synonyms: 3',4'-Dimethoxy-αNF)

目录号: HY-103222 纯度: 98.01%
COA 产品使用指南

摩尔计算器

DiMNF (3',4'-Dimethoxy-αNF) 是一种选择性芳基烃受体 (AHR) 调节剂。 DiMNF 是一种具有明显拮抗活性的竞争性 AHR 配体 (IC50 = 21 nM)。 DiMNF 可用作抗炎剂。

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DiMNF Chemical Structure

DiMNF Chemical Structure

CAS No. : 14756-24-2

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1100
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5 mg ￥1000
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10 mg ￥1600
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25 mg ￥3500
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50 mg ￥5500
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Customer Review

DiMNF 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
2008 IC50
1.76 μM
Compound: 16
Inhibition of MRP1 (unknown origin) expressed in human 2008 cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay
Inhibition of MRP1 (unknown origin) expressed in human 2008 cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay
[PMID: 23851114]
A2780 ADR IC50
4 μM
Compound: 16
Inhibition of p-glycoprotein (unknown origin) expressed in human A2780Adr cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay
Inhibition of p-glycoprotein (unknown origin) expressed in human A2780Adr cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay
[PMID: 23851114]
MDCK-II IC50
1.13 μM
Compound: 16
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of pheophorbide-A preincubated for 30 mins before pheophorbide-A addition measured after 120 mins by flow cytometry
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of pheophorbide-A preincubated for 30 mins before pheophorbide-A addition measured after 120 mins by flow cytometry
[PMID: 23851114]
MDCK-II IC50
1.23 μM
Compound: 16
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of Hoechst 33342 preincubated for 30 mins before Hoechst 33342 addition measured after 120 mins by fluorescence assay
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of Hoechst 33342 preincubated for 30 mins before Hoechst 33342 addition measured after 120 mins by fluorescence assay
[PMID: 23851114]
体外研究
(In Vitro)

DiMNF (3',4'-Dimethoxy-αNF) (10 μM; 4 h) minimally influences AHR gene battery[1].
DiMNF (10 μM; 1 h) effectively suppresses cytokine-mediated inflammatory gene expression[1].
DiMNF adopts a unique orientation within the ligand binding pocket of AHR[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DiMNF 相关抗体:

RT-PCR[1]

Cell Line: Huh7 cell
Concentration: 10 μM
Incubation Time: 4 h or 1 h
Result: Decreased CYP1A1 mRNA expression (4 h). Exhibited repressive activity toward cytokine-mediated SAA1 induction (1 h). Significantly reduced IL1β-mediated mRNA induction of C4, C1S, C1R, and C3.
分子量

332.35

Formula

C21H16O4
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 12.5 mg/mL (37.61 mM; 超声助溶 (<70°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0089 mL 15.0444 mL 30.0888 mL
5 mM 0.6018 mL 3.0089 mL 6.0178 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

DiMNF 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0089 mL 15.0444 mL 30.0888 mL 75.2219 mL
5 mM 0.6018 mL 3.0089 mL 6.0178 mL 15.0444 mL
10 mM 0.3009 mL 1.5044 mL 3.0089 mL 7.5222 mL
15 mM 0.2006 mL 1.0030 mL 2.0059 mL 5.0148 mL
20 mM 0.1504 mL 0.7522 mL 1.5044 mL 3.7611 mL
25 mM 0.1204 mL 0.6018 mL 1.2036 mL 3.0089 mL
30 mM 0.1003 mL 0.5015 mL 1.0030 mL 2.5074 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DiMNF14756-24-23',4'-Dimethoxy-αNFAryl Hydrocarbon ReceptorAhRanti-inflammatoryHuh7Inhibitorinhibitorinhibit

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目录号：
HY-103222
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