2. PI3K/Akt/mTOR Apoptosis
  3. Akt PI3K Apoptosis
  4. Apoptin-derived peptide

Apoptin-derived peptide 是一种抗癌活性多肽，具有细胞毒性。Apoptin-derived peptide 通过调节 PI3K/AKT/ARNT 信号而促进胃癌细胞的凋亡 (apoptosis) 和坏死 (necrosis)。在细胞内，Apoptin-derived peptide 抑制癌细胞侵袭和迁移，并抑制 PI3K 的亚基 p85 的表达和磷酸化，进一步抑制胃癌发展有关的 PI3K/AKT 通路。

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Custom Peptide Synthesis

Apoptin-derived peptide Chemical Structure

Apoptin-derived peptide Chemical Structure

CAS No. : 2232156-31-7

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Apoptin-derived peptide 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and necrosis of gastric cancer (GC) cells by regulating PI3K/AKT/ARNT signaling. Apoptin-derived peptide inhibited the invasion and migration of cancer cells, and inhibited the expression and phosphorylation of the subunit p85 of PI3K, which further inhibited the PI3K/AKT pathway involved in the development of gastric cancer[1].

体外研究
(In Vitro)

Apoptin-derived peptide (40-100 μg/mL, 24 h) 通过抑制 PI3K/AKT 信号通路促进 ARNT 下调，从而逆转 SGC-7901/CDDP 细胞对 CDDP 的耐药性[1]。
Apoptin-derived peptide (10-30 μg/mL, 24 h) 抑制 SGC-7901、SGC-7901/CDDP 和 MGC-803 细胞的迁移和侵袭[1]。
Apoptin-derived peptide (30-60 μg/mL, 24 h) 增加 SGC-7901/CDDP 细胞对 CDDP 的敏感性[1]。
Apoptin-derived peptide (10-20 μg/mL, 24 h) 增加 SGC-7901/CDDP 细胞的 G2/M 期细胞比例并诱导细胞凋亡[1]。
Apoptin-derived peptide (10-70 μg/mL, 4-24 h) 对胃癌细胞有很好的抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptin-derived peptide 相关抗体:

Cell Viability Assay[1]

Cell Line: HEK293, SGC-7901, SGC-7901/CDDP
Concentration: 10 μg/mL, 20 μg/mL, 30 μg/mL, 40 μg/mL, 50 μg/mL, 60 μg/mL, 70 μg/mL
Incubation Time: 4 h, 6 h, 8 h, 12 h, 18 h, 24 h
Result: Produced large effects in both SGC-7901 and SGC-7901/CDDP cells at 60 μg/mL for 6 h and had no obvious effect on HEK293 cells.

Apoptosis Analysis[1]

Cell Line: SGC-7901, SGC-7901/CDDP
Concentration: 30 μg/mL, 60 μg/mL
Incubation Time: 24 h
Result: Induced SGC-7901 cell apoptosis in a concentration dependent manner.
Induced considerable apoptotic cell death in SGC-7901/CDDP cells in a strong time- and dose-dependent fashion.

Cell Cycle Analysis[1]

Cell Line: SGC-7901, SGC-7901/CDDP
Concentration: 10 μg/mL, 20 μg/mL
Incubation Time: 24 h
Result: Increase the G2/M phase population.

Cell Invasion Assay[1]

Cell Line: SGC-7901, SGC-7901/CDDP, MGC-803
Concentration: 10 μg/mL, 20 μg/mL, 30 μg/mL
Incubation Time: 48 h
Result: Significantly reduced the number of invasive cells.

Cell Migration Assay [1]

Cell Line: SGC-7901, SGC-7901/CDDP, MGC-803
Concentration: 10 μg/mL, 20 μg/mL, 30 μg/mL
Incubation Time: 48 h
Result: Effectively inhibited the migration ability of MGC-803, SGC-7901, and SGC-7901/CDDP cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: SGC-7901, SGC-7901/CDDP
Concentration: 40 μg/mL, 60 μg/mL, 80 μg/mL, 100 μg/mL
Incubation Time: 24 h
Result: Significantly down-regulated the phosphorylation of p85 (p-p85) and AKT (p-AKT) proteins at concentrations from 40 μg/mL to 100 μg/mL.
Down-regulated the expression of MDR1 and ARTN in Apoptin-derived peptide-treated SGC-7901/CDDP cells.
Notably decreased p85 and AKT activities.
分子量

5177.33

Formula

C223H417N89O50S
CAS 号
Sequence

Met-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Pro-Pro-Ser-Lys-Lys-Arg-Ile-Arg-Ile-Gly-Ile-Ala-Gly-Ile-Thr-Ile-Thr-Leu-Ser-Leu-Arg-Pro-Arg-Thr-Ala-Lys-Arg-Arg-Ile-Arg-Leu
Sequence Shortening

MGRKKRRQRRRKPPSKKRIRIGIAGITITLSLRPRTAKRRIRL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptin-derived peptide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptin-derived peptide2232156-31-7AktPI3KApoptosisPKBProtein kinase BPhosphoinositide 3-kinaseSGC-7901SGC-7901/CDDPMGC-803SW-620U87-MGU251-MGHEK293Inhibitorinhibitorinhibit

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目录号：
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