GPS2 - G protein pathway suppressor 2 Gene

中文名称：G 蛋白通路抑制因子 2

种属: Homo sapiens

同用名: AMF-1

关于 GPS2

功能概要

该基因编码一种参与 G 蛋白-丝裂原活化蛋白激酶 (MAPK) 信号级联的蛋白质。当在哺乳动物细胞中过表达时，该基因可有效抑制 Ras 和 MAPK 介导的信号并干扰 JNK 活性，表明该基因的功能可能是信号抑制。编码的蛋白质是 NCOR1-HDAC3 (核受体共阻遏物 1-组蛋白去乙酰化酶 3) 复合物的一个完整亚基，结果表明该复合物通过该亚基抑制 JNK 激活，因此可能为激素介导的拮抗作用提供替代机制 AP1 (激活蛋白 1) 的功能。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]