2. Gene
  3. POU2AF1 - POU class 2 homeobox associating factor 1 Gene

POU2AF1 - POU class 2 homeobox associating factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：POU 2 类同源框关联因子 1

种属: Homo sapiens

同用名: BOB1; OBF1; OCAB; OBF-1

基因 ID: 5450 | 基因类型: protein coding

关于 POU2AF1

Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:111,352,255-111,379,275 (from NCBI)

This gene has 12 transcripts (splice variants), 118 orthologues and is associated with 57 phenotypes. Biased expression in lymph node (RPKM 29.3), appendix (RPKM 16.6) and 9 other tissues.

功能概要

启用转录共激活因子活性。参与 RNA 聚合酶 II 对转录的正调控。 RNA 聚合酶 II 转录调节复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

POU2AF1 基因产物(1)

mRNA Protein Name
NM_006235.3 NP_006226.2 POU domain class 2-associating factor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11483518 GOA
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
11380252 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
11380252 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
11380252 GOA
part of RNA polymerase II transcription regulator complex IMP
IMP: 通过突变表型推断
10329190 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POU2AF1 蛋白结构

PD-C2-AF1

PD-C2-AF1: POU domain, class 2, associating factor 1 (1 - 255)

  • 0
  • 100
  • 200
  • 256 a.a.
蛋白主名 其他名称

POU domain class 2-associating factor 1

B-cell-specific coactivator OBF-1

POU2AF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
POU2AF1 Q16633 KRTAP19-7 Homo sapiens Q3SYF9
Validated Y2H
32296183
种属内
POU2AF1 Q16633 HEMK1 Homo sapiens Q9Y5R4
Validated Y2H
32296183
种属内
POU2AF1 Q16633 ATE1 Homo sapiens O95260
Anti Tag CoIP
33961781
种属内
POU2AF1 Q16633 ATE1 Homo sapiens O95260
Anti Tag CoIP
28514442
种属内
POU2AF1 Q16633 KRTAP19-5 Homo sapiens Q3LI72
Validated Y2H
32296183
种属内
POU2AF1 Q16633 KRTAP13-2 Homo sapiens Q52LG2
Validated Y2H
32296183
种属内
POU2AF1 Q16633 KRTAP15-1 Homo sapiens Q3LI76
Validated Y2H
32296183
种属内
POU2AF1 Q16633 KRTAP19-3 Homo sapiens Q7Z4W3
Validated Y2H
32296183
种属内
POU2AF1 Q16633 PITX2 Homo sapiens Q99697-2
Validated Y2H
32296183
种属内
POU2AF1 Q16633 RBM24 Homo sapiens Q9BX46-2
Validated Y2H
32296183
种属内
POU2AF1 Q16633 NDUFAF3 Homo sapiens Q9BU61
Validated Y2H
32296183
种属内
POU2AF1 Q16633 TFG Homo sapiens Q92734
Validated Y2H
32296183
种属内
POU2AF1 Q16633 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
32296183
种属内
POU2AF1 Q16633 HGS Homo sapiens O14964
Y2H Prey Pooling
32296183
种属内
POU2AF1 Q16633 DGCR6L Homo sapiens Q9BY27
Validated Y2H
32296183
种属内
POU2AF1 Q16633 RAMAC Homo sapiens Q9BTL3
Validated Y2H
32296183
种属内
POU2AF1 Q16633 ZNF414 Homo sapiens Q96IQ9
Validated Y2H
32296183
种属内
POU2AF1 Q16633 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
种属内
POU2AF1 Q16633 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32296183
种属内
POU2AF1 Q16633 SIAH1 Homo sapiens Q8IUQ4
Y2H
11483518
种属内
POU2AF1 Q16633 SIAH1 Homo sapiens Q8IUQ4
Pull Down
11483518
种属内
POU2AF1 Q16633 TENT5B Homo sapiens Q96A09
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

POU2AF1 抗体

目录号 产品名 应用 反应物种
HY-P82467 BOB1 Antibody (YA2212) WB, IHC-P, ICC/IF, FC Human

关联疾病

疾病名称 别名
Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis
Mediastinal Gray Zone Lymphoma

Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Mediastinal Malignant Lymphoma

Lymphoma Of Mediastinum

Mediastinal Lymphoma
Gray Zone Lymphoma

B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Hodgkin'S Lymphoma, Lymphocytic Depletion

Hodgkin Lymphoma, Lymphocyte Depletion

Hodgkin'S Disease, Lymphocytic Depletion

Hodgkin'S Lymphocytic Depletion Of Unspecified Site

Lymphocyte-Depleted Classical Hodgkin Lymphoma

Classic Hodgkin Lymphoma, Lymphocyte-Depleted Type

Hodgkin Disease, Lymphocytic Depletion

Hodgkin Lymphocytic Depletion
Methotrexate-Associated Lymphoproliferation
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
Hodgkin'S Lymphoma, Nodular Sclerosis

Classical Hodgkin Lymphoma, Nodular Sclerosis

Classic Hodgkin Lymphoma, Nodular Sclerosis Type

Nodular Sclerosis Hodgkin Lymphoma

Hodgkin'S Disease, Nodular Sclerosis

Hodgkin Disease, Nodular Sclerosis

Hodgkin Lymphoma, Nodular Sclerosis

Hodgkin Nodular Sclerosis
Appendix Lymphoma

Appendiceal Lymphoma
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10896 POU2AF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta POU2AF1 VGNC VGNC:76222
Felis catus POU2AF1 VGNC VGNC:81957
Mus musculus POU2AF1 MGD MGI:105086
Canis familiaris POU2AF1 VGNC VGNC:44825
Rattus norvegicus POU2AF1 RGD RGD:1594728
Bos taurus POU2AF1 VGNC VGNC:33173
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