ATE1 - arginyltransferase 1 Gene

中文名称：精氨酰转移酶 1

种属: Homo sapiens

基因 ID: 11101 | 基因类型: protein coding

关于 ATE1

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:121,740,424-121,928,463 (from NCBI)

This gene has 73 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in thyroid (RPKM 8.9), testis (RPKM 7.9) and 25 other tissues.

功能概要

该基因编码精氨酰转移酶，该酶参与精氨酸与 N 末端天冬氨酸或谷氨酸残基的翻译后结合。精氨酸与 N 末端天冬氨酸或谷氨酸的结合靶向泛素依赖性降解的蛋白质。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 12 月]

This gene encodes an arginyltransferase, an Enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

ATE1 基因产物(5)

mRNA	Protein	Name
NM_001001976.3	NP_001001976.1	arginyl-tRNA--protein transferase 1 isoform 1
NM_001288734.2	NP_001275663.1	arginyl-tRNA--protein transferase 1 isoform 3
NM_001288735.2	NP_001275664.1	arginyl-tRNA--protein transferase 1 isoform 4
NM_001288736.2	NP_001275665.1	arginyl-tRNA--protein transferase 1 isoform 5
NM_007041.4	NP_008972.2	arginyl-tRNA--protein transferase 1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables arginyl-tRNA--protein transferase activity	IDA IDA: 通过直接分析推断	34893540	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23455924	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within proteasomal protein catabolic process	IMP IMP: 通过突变表型推断	25970626	GOA
involved in response to oxidative stress	IDA IDA: 通过直接分析推断	34893540	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	34893540	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	9858543	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9858543	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATE1 蛋白结构

ATE_N

ATE_C

0
100
200
300
400
518 a.a.

蛋白主名

其他名称

arginyl-tRNA--protein transferase 1

R-transferase 1

ATE1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ATE1	O95260	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	23455924

种属间: 跨种属相互作用 种属内: 同种属相互作用

ATE1 抗体

目录号	产品名	应用	反应物种
HY-P82433	ATE1 Antibody (YA2178)	WB, IHC-P	Human, Rat

关联疾病

疾病名称

别名

Johanson-Blizzard Syndrome

JBS	Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness
Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness	Johanson Blizzard Syndrome

Chromosome 10q26 Deletion Syndrome

Distal 10q Deletion Syndrome	Terminal Chromosome 10q26 Deletion Syndrome
Distal Monosomy 10q	Monosomy 10qter
Telomeric Deletion 10q	Distal Deletion 10q
10q26 Deletion Syndrome	10qter Deletion
Telomeric Deletion 10

Beare-Stevenson Cutis Gyrata Syndrome

Cutis Gyrata Syndrome Of Beare And Stevenson	Beare-Stevenson Syndrome
BSTVS	Cutis Gyrata-Acanthosis Nigricans-Craniosynostosis Syndrome
Beare Stevenson Syndrome	Cutis Gyrata - Acanthosis Nigricans - Craniosynostosis
Cutis Gyrata Syndrome Of Beare-Stevenson

Jackson-Weiss Syndrome

JWS	Craniosynostosis, Midfacial Hypoplasia, And Foot Abnormalities
Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities Syndrome	Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01126	ATE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ATE1	MGD	MGI:1333870
Rattus norvegicus	ATE1	RGD	RGD:1309335
Macaca mulatta	ATE1	VGNC	VGNC:70168
Bos taurus	ATE1	VGNC	VGNC:26238
Felis catus	ATE1	VGNC	VGNC:68493
Canis familiaris	ATE1	VGNC	VGNC:38206

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ATE1 - arginyltransferase 1 Gene

关于 ATE1

功能概要

ATE1 基因产物(5)

ATE1 蛋白结构

ATE1 蛋白互作信息

ATE1 抗体

关联疾病

直系同源

热门区域

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ATE1 - arginyltransferase 1 Gene

关于 ATE1

功能概要

ATE1 基因产物(5)

ATE1 蛋白结构

ATE1 蛋白互作信息

ATE1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z