2. Gene
  3. INTS11 - integrator complex subunit 11 Gene

INTS11 - integrator complex subunit 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：整合复合物亚基 11

种属: Homo sapiens

同用名: RC68; INT11; RC-68; CPSF3L; CPSF73L

基因 ID: 54973 | 基因类型: protein coding

关于 INTS11

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,311,600-1,324,660 (from NCBI)

This gene has 49 transcripts (splice variants), 202 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 35.0), endometrium (RPKM 21.3) and 25 other tissues.

功能概要

Integrator 复合物包含至少 12 个亚基，并与 RNA 聚合酶 II 大亚基 (POLR2A；MIM 180660) 的 C 端结构域相关联，并介导小核 RNA U1 (RNU1；MIM 180680) 和 U2 ( RNU2；MIM 180690) 。 INTS11 或 CPSF3L 是 Integrator 复合体的催化亚基 (Baillat 等人，2005 [PubMed 16239144]) 。[OMIM 提供，2008 年 3 月]

The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

INTS11 基因产物(5)

mRNA Protein Name
NM_001256456.2 NP_001243385.1 integrator complex subunit 11 isoform 1
NM_001256460.2 NP_001243389.1 integrator complex subunit 11 isoform 3
NM_001256462.2 NP_001243391.1 integrator complex subunit 11 isoform 4
NM_001256463.2 NP_001243392.1 integrator complex subunit 11 isoform 5
NM_017871.6 NP_060341.2 integrator complex subunit 11 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA endonuclease activity IMP
IMP: 通过突变表型推断
16239144 GOA
contributes to protein binding IPI
IPI: 通过物理相互作用推断
16239144 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24981860 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in snRNA processing IDA
IDA: 通过直接分析推断
16239144 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23904267 GOA
part of integrator complex IDA
IDA: 通过直接分析推断
16239144 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23904267 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

INTS11 蛋白结构

Lactamase_B

Lactamase_B: Metallo-beta-lactamase superfamily (15 - 189)

Beta-Casp

Beta-Casp: Beta-Casp domain (245 - 363)

RMMBL

RMMBL: Zn-dependent metallo-hydrolase RNA specificity domain (377 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600 a.a.
蛋白主名 其他名称

integrator complex subunit 11

CPSF3-like protein

INTS11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
INTS11 Q5TA45 TCF7L2 Homo sapiens Q9NQB0-10
Validated Y2H
32296183
种属内
INTS11 Q5TA45 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
种属内
INTS11 Q5TA45 KRTAP15-1 Homo sapiens Q3LI76
Y2H Array
32296183
种属内
INTS11 Q5TA45 HSF4 Homo sapiens Q9ULV5-2
Validated Y2H
32296183
种属内
INTS11 Q5TA45 SPIC Homo sapiens Q8N5J4
Validated Y2H
32296183
种属内
INTS11 Q5TA45 OXER1 Homo sapiens Q8TDS5
Validated Y2H
32296183
种属内
INTS11 Q5TA45 OXER1 Homo sapiens Q8TDS5
Y2H Array
32296183
种属内
INTS11 Q5TA45 OXER1 Homo sapiens Q8TDS5
Y2H Prey Pooling
32296183
种属内
INTS11 Q5TA45 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
种属内
INTS11 Q5TA45 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
种属内
INTS11 Q5TA45 FAM222B Homo sapiens Q8WU58
Validated Y2H
32296183
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
GMS
32647223
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
Chromatography
36180473
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
X-Ray Diffraction
28396433
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
Crosslink
33548203
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
3D-EM
33548203
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
Crosslink
32647223
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
Pull Down
33548203
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
Y2H
28396433
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
GMS
33548203
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
TAP
24981860
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
GMS
36180473
种属内
INTS11 Q5TA45 INTS9 Homo sapiens Q9NV88
Anti Tag CoIP
28396433
种属内
INTS11 Q5TA45 TFG Homo sapiens Q92734
Validated Y2H
32296183
种属内
INTS11 Q5TA45 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
种属内
INTS11 Q5TA45 LENG8 Homo sapiens Q96PV6
Validated Y2H
32296183
种属内
INTS11 Q5TA45 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
种属内
INTS11 Q5TA45 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
种属内
INTS11 Q5TA45 PLSCR4 Homo sapiens Q9NRQ2
Validated Y2H
32296183
种属内
INTS11 Q5TA45 C1orf94 Homo sapiens Q6P1W5
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Galloway-Mowat Syndrome

Galloway Mowat Syndrome

Galloway Syndrome

Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

Microcephaly Nephrosis Syndrome

Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

Nephrosis Neuronal Dysmigration Syndrome

Microcephaly-Hiatus Hernia-Nephrotic Syndrome

Nephrosis-Neuronal Dysmigration Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06852 INTS11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus INTS11 RGD RGD:1306841
Canis familiaris INTS11 VGNC VGNC:42047
Felis catus INTS11 VGNC VGNC:62939
Macaca mulatta INTS11 VGNC VGNC:73658
Mus musculus INTS11 MGD MGI:1919207
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