1. Gene
  2. INTS9 - integrator complex subunit 9 Gene

INTS9 - integrator complex subunit 9 Gene

中文名称:整合复合体亚基 9

种属: Homo sapiens

同用名: INT9; RC74; CPSF2L

基因 ID: 55756 | 基因类型: protein coding

关于 INTS9

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:28,767,661-28,889,969 (from NCBI)

This gene has 19 transcripts (splice variants), 203 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 6.2), adrenal (RPKM 5.5) and 25 other tissues.

功能概要

该基因编码整合复合体的一个亚基。这种蛋白质复合物结合 RNA 聚合酶 II 的 C 末端结构域,并可能在小核 RNA 加工中发挥作用。编码的蛋白质与切割和聚腺苷酸化特异性因子复合物的亚基有相似之处。已经描述了选择性剪接的转录变体。[RefSeq 提供,2010 年 2 月]

This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

INTS9 基因产物(4)

mRNA Protein Name
NM_001145159.3 NP_001138631.1 integrator complex subunit 9 isoform 2
NM_001172562.2 NP_001166033.1 integrator complex subunit 9 isoform 3
NM_001363038.2 NP_001349967.1 integrator complex subunit 9 isoform 4
NM_018250.4 NP_060720.2 integrator complex subunit 9 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16239144 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
36641752 GOA
involved in snRNA processing IDA
IDA: 通过直接分析推断
16239144 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of integrator complex IDA
IDA: 通过直接分析推断
16239144 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23904267 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

INTS9 蛋白结构

Beta-Casp

Beta-Casp: Beta-Casp domain (307 - 426)

  • 0
  • 200
  • 400
  • 600
  • 658 a.a.
蛋白主名 其他名称

integrator complex subunit 9

protein related to CPSF subunits of 74 kDa

INTS9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
INTS9 Q9NV88 INTS4 Homo sapiens Q96HW7 33548203
种属内
INTS9 Q9NV88 INTS4 Homo sapiens Q96HW7 33548203
种属内
INTS9 Q9NV88 INTS4 Homo sapiens Q96HW7 33961781
种属内
INTS9 Q9NV88 INTS11 Homo sapiens Q5TA45 33961781
种属内
INTS9 Q9NV88 INTS11 Homo sapiens Q5TA45 33548203
种属内
INTS9 Q9NV88 INTS11 Homo sapiens Q5TA45 33548203
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immature Cataract

Incipient Cataract

Incipient Senile Cataract

Water Clefts

Galloway-Mowat Syndrome

Galloway Mowat Syndrome

Galloway Syndrome

Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

Microcephaly Nephrosis Syndrome

Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

Nephrosis Neuronal Dysmigration Syndrome

Microcephaly-Hiatus Hernia-Nephrotic Syndrome

Nephrosis-Neuronal Dysmigration Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus INTS9 VGNC VGNC:30234
Rattus norvegicus INTS9 RGD RGD:1311539
Macaca mulatta INTS9 VGNC VGNC:73654
Mus musculus INTS9 MGD MGI:1098533
Canis familiaris INTS9 VGNC VGNC:42058
Felis catus INTS9 VGNC VGNC:62949