FHL5 - four and a half LIM domains 5 Gene

中文名称：四个半 LIM 域 5

种属: Homo sapiens

同用名: ACT; FHL-5; dJ393D12.2; 1700027G07Rik

基因 ID: 9457 | 基因类型: protein coding

关于 FHL5

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:96,562,574-96,618,626 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in testis (RPKM 16.0), fat (RPKM 12.3) and 18 other tissues.

功能概要

该基因编码的蛋白质与 cAMP 反应元件调节剂 (CREM) 的激活剂协同表达。它与 CREM 相关并赋予强大的转录激活功能。 CREM 是精子细胞分化为成熟精子所必需的转录因子。在该基因中发现了多个聚腺苷酸化位点。该基因的多态性可能与偏头痛的易感性有关。可变剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2016 年 4 月]

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]

FHL5 基因产物(4)

mRNA	Protein	Name
NM_001170807.3	NP_001164278.1	four and a half LIM domains protein 5
NM_001322466.2	NP_001309395.1	four and a half LIM domains protein 5
NM_001322467.1	NP_001309396.1	four and a half LIM domains protein 5
NM_020482.6	NP_065228.4	four and a half LIM domains protein 5

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FHL5 蛋白结构

LIM

0
100
200
284 a.a.

蛋白主名

其他名称

four and a half LIM domains protein 5

LIM protein ACT

FHL5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FHL5	Q5TD97	ZNF131	Homo sapiens	P52739-2	Anti Tag CoIP	28514442
种属内	FHL5	Q5TD97	ZNF564	Homo sapiens	Q8TBZ8	Validated Y2H	32296183
种属内	FHL5	Q5TD97	KIR2DL4	Homo sapiens	Q99706	Validated Y2H	32296183
种属内	FHL5	Q5TD97	HDX	Homo sapiens	Q7Z353	Validated Y2H	32296183
种属内	FHL5	Q5TD97	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
种属内	FHL5	Q5TD97	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
种属内	FHL5	Q5TD97	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
种属内	FHL5	Q5TD97	IP6K3	Homo sapiens	Q96PC2	Validated Y2H	32296183
种属内	FHL5	Q5TD97	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
种属内	FHL5	Q5TD97	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
种属内	FHL5	Q5TD97	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
种属内	FHL5	Q5TD97	SHFL	Homo sapiens	Q9NUL5-4	Validated Y2H	32296183
种属内	FHL5	Q5TD97	HAPLN2	Homo sapiens	Q9GZV7	Validated Y2H	32296183
种属内	FHL5	Q5TD97	CDC20B	Homo sapiens	Q86Y33-5	Validated Y2H	32296183
种属内	FHL5	Q5TD97	DLGAP4	Homo sapiens	Q9Y2H0-1	Validated Y2H	32296183
种属内	FHL5	Q5TD97	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
种属内	FHL5	Q5TD97	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Array	32296183
种属内	FHL5	Q5TD97	ZNF613	Homo sapiens	Q6PF04	Validated Y2H	32296183
种属内	FHL5	Q5TD97	NUFIP2	Homo sapiens	Q7Z417	Validated Y2H	32296183
种属内	FHL5	Q5TD97	BBC3	Homo sapiens	Q96PG8	Validated Y2H	32296183
种属内	FHL5	Q5TD97	COL26A1	Homo sapiens	Q96A83-2	Y2H Array	32814053
种属内	FHL5	Q5TD97	COL26A1	Homo sapiens	Q96A83-2	Validated Y2H	32814053
种属内	FHL5	Q5TD97	COL26A1	Homo sapiens	Q96A83-2	Y2H Pooling	32814053
种属内	FHL5	Q5TD97	MISP	Homo sapiens	Q8IVT2	Validated Y2H	32296183
种属内	FHL5	Q5TD97	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	32296183
种属内	FHL5	Q5TD97	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
种属内	FHL5	Q5TD97	ZNF408	Homo sapiens	Q9H9D4	Validated Y2H	32296183
种属间	FHL5	Q5TD97	Hoxa1	Mus musculus	P09022	Y2H	23088713
种属间	FHL5	Q5TD97	Hoxa1	Mus musculus	P09022	Pull Down	23088713
种属内	FHL5	Q5TD97	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	32296183
种属内	FHL5	Q5TD97	PLEKHA2	Homo sapiens	Q9HB19	Validated Y2H	32296183
种属内	FHL5	Q5TD97	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	FHL5	Q5TD97	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	FHL5	Q5TD97	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	FHL5	Q5TD97	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
种属内	FHL5	Q5TD97	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
种属内	FHL5	Q5TD97	ZNF251	Homo sapiens	Q9BRH9	Validated Y2H	32296183
种属内	FHL5	Q5TD97	ZNF440	Homo sapiens	Q8IYI8	Validated Y2H	32296183
种属内	FHL5	Q5TD97	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
种属内	FHL5	Q5TD97	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
种属内	FHL5	Q5TD97	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
种属内	FHL5	Q5TD97	DNAL4	Homo sapiens	O96015	Y2H Pooling	16189514
种属内	FHL5	Q5TD97	DNAL4	Homo sapiens	O96015	Y2H	21516116
种属内	FHL5	Q5TD97	RAB3IL1	Homo sapiens	Q8TBN0	Validated Y2H	32296183
种属内	FHL5	Q5TD97	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
种属内	FHL5	Q5TD97	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	32296183
种属内	FHL5	Q5TD97	ATOSB	Homo sapiens	Q7L5A3	Y2H	21516116
种属内	FHL5	Q5TD97	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	32296183
种属内	FHL5	Q5TD97	ZNF764	Homo sapiens	Q96H86	Validated Y2H	32296183
种属内	FHL5	Q5TD97	MAGOHB	Homo sapiens	Q96A72	Validated Y2H	32296183
种属内	FHL5	Q5TD97	SCNM1	Homo sapiens	Q9BWG6	Anti Tag CoIP	33961781
种属内	FHL5	Q5TD97	SCNM1	Homo sapiens	Q9BWG6	Anti Tag CoIP	28514442
种属内	FHL5	Q5TD97	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
种属内	FHL5	Q5TD97	NPDC1	Homo sapiens	Q9NQX5	Validated Y2H	32296183
种属内	FHL5	Q5TD97	HEY2	Homo sapiens	Q9UBP5	Validated Y2H	32296183
种属内	FHL5	Q5TD97	GARIN6	Homo sapiens	Q8NEG0	Validated Y2H	32296183
种属内	FHL5	Q5TD97	CTSZ	Homo sapiens	Q9UBR2	Validated Y2H	32296183
种属内	FHL5	Q5TD97	ADAMTSL5	Homo sapiens	Q6ZMM2	Validated Y2H	32296183
种属内	FHL5	Q5TD97	RAB26	Homo sapiens	Q9ULW5	Validated Y2H	32296183
种属内	FHL5	Q5TD97	RAB26	Homo sapiens	Q9ULW5	Y2H Prey Pooling	32296183
种属内	FHL5	Q5TD97	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Migraine Without Aura

Common Migraine	Migraine With Or Without Aura, Susceptibility To
Migraine Without Aura, Susceptibility To	Acute Migraine Without Aura

Migraine With Aura

Classic Migraine	Migraine With Typical Aura
Migraine Accompagnée	Complicated Migraine
Classical Migraine	Acute Migraine With Aura

Frontometaphyseal Dysplasia

Fmd	Dysplasia, Frontometaphyseal

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04937	FHL5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	FHL5	VGNC	VGNC:62267
Rattus norvegicus	FHL5	RGD	RGD:1307056
Canis familiaris	FHL5	VGNC	VGNC:40874
Mus musculus	FHL5	MGD	MGI:1913192
Bos taurus	FHL5	VGNC	VGNC:29002
Macaca mulatta	FHL5	VGNC	VGNC:72521
Others	FHL5	NCBI

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