SAXO1 - stabilizer of axonemal microtubules 1 Gene

中文名称：轴丝微管稳定因子 1

种属: Homo sapiens

同用名: FAM154A; C9orf138

基因 ID: 158297 | 基因类型: protein coding

关于 SAXO1

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:18,927,650-19,049,339 (from NCBI)

This gene has 5 transcripts (splice variants), 135 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 15.1).

功能概要

启用微管结合活动。涉及几个过程，包括冷驯化；纤毛组装的正调控；和蛋白质稳定。位于微管细胞骨架和精子鞭毛中。 [由基因组资源联盟提供，2022 年 4 月]

Enables microtubule binding activity. Involved in several processes, including cold acclimation; positive regulation of cilium assembly; and protein stabilization. Located in microtubule Cytoskeleton and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]

SAXO1 基因产物(3)

mRNA	Protein	Name
NM_001287049.2	NP_001273978.1	stabilizer of axonemal microtubules 1 isoform b
NM_001287050.2	NP_001273979.1	stabilizer of axonemal microtubules 1 isoform c
NM_153707.4	NP_714918.2	stabilizer of axonemal microtubules 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables microtubule binding	IDA IDA: 通过直接分析推断	25673876	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23088713	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to cold	IDA IDA: 通过直接分析推断	25673876	GOA
involved in cold acclimation	IDA IDA: 通过直接分析推断	25673876	GOA
involved in positive regulation of cilium assembly	IMP IMP: 通过突变表型推断	25673876	GOA
involved in protein stabilization	IDA IDA: 通过直接分析推断	25673876	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in axonemal microtubule	IDA IDA: 通过直接分析推断	25673876	GOA
located in centriole	IDA IDA: 通过直接分析推断	25673876	GOA
located in ciliary basal body	IDA IDA: 通过直接分析推断	25673876	GOA
located in motile cilium	IDA IDA: 通过直接分析推断	25673876	GOA
located in sperm flagellum	IDA IDA: 通过直接分析推断	25673876	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SAXO1 蛋白结构

STOP

0
100
200
300
400
474 a.a.

蛋白主名

其他名称

stabilizer of axonemal microtubules 1

4930500O09Rik

SAXO1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SAXO1	Q8IYX7	IQUB	Homo sapiens	Q8NA54	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	VPS28	Homo sapiens	Q548N1	Y2H Array	25416956
种属内	SAXO1	Q8IYX7	NUDT22	Homo sapiens	Q9BRQ3	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	POLR1C	Homo sapiens	O15160	Validated Y2H	25416956
种属内	SAXO1	Q8IYX7	POLR1C	Homo sapiens	O15160	Y2H Prey Pooling	25416956
种属内	SAXO1	Q8IYX7	TNK1	Homo sapiens	Q13470-2	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	TNK1	Homo sapiens	Q13470-2	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	CPNE7	Homo sapiens	Q9UBL6-2	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	FBXO17	Homo sapiens	Q96EF6	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	BAG4	Homo sapiens	O95429	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
种属间	SAXO1	Q8IYX7	Hoxa1	Mus musculus	P09022	BiFC	23088713
种属内	SAXO1	Q8IYX7	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	TRIB3	Homo sapiens	Q96RU7	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	OIP5	Homo sapiens	O43482	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	HEXIM2	Homo sapiens	Q96MH2	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	25416956
种属内	SAXO1	Q8IYX7	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
种属内	SAXO1	Q8IYX7	LMO2	Homo sapiens	P25791	Y2H Array	25416956
种属内	SAXO1	Q8IYX7	FHL3	Homo sapiens	Q13643	Validated Y2H	25416956
种属内	SAXO1	Q8IYX7	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	SORBS3	Homo sapiens	O60504	Validated Y2H	25416956
种属内	SAXO1	Q8IYX7	SORBS3	Homo sapiens	O60504	Y2H Array	25416956
种属内	SAXO1	Q8IYX7	BEGAIN	Homo sapiens	Q9BUH8	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	BEGAIN	Homo sapiens	Q9BUH8	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	BEGAIN	Homo sapiens	Q9BUH8	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
种属内	SAXO1	Q8IYX7	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
种属内	SAXO1	Q8IYX7	GFAP	Homo sapiens	P14136	Y2H Array	32814053
种属内	SAXO1	Q8IYX7	FAM124A	Homo sapiens	Q86V42	Y2H Array	25416956
种属内	SAXO1	Q8IYX7	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	ZMYND19	Homo sapiens	Q96E35	Y2H Array	25416956
种属内	SAXO1	Q8IYX7	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
种属内	SAXO1	Q8IYX7	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	GLYCTK	Homo sapiens	Q8IVS8	Validated Y2H	25416956
种属内	SAXO1	Q8IYX7	GLYCTK	Homo sapiens	Q8IVS8	Y2H Prey Pooling	25416956
种属内	SAXO1	Q8IYX7	STK16	Homo sapiens	O75716	Y2H Prey Pooling	25416956
种属内	SAXO1	Q8IYX7	STK16	Homo sapiens	O75716	Validated Y2H	25416956
种属内	SAXO1	Q8IYX7	STK16	Homo sapiens	O75716	Y2H Array	25416956
种属内	SAXO1	Q8IYX7	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
种属内	SAXO1	Q8IYX7	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	ACTN2	Homo sapiens	P35609	Validated Y2H	25416956
种属内	SAXO1	Q8IYX7	ACTN2	Homo sapiens	P35609	Y2H Array	31515488
种属内	SAXO1	Q8IYX7	ACTN2	Homo sapiens	P35609	Y2H Prey Pooling	25416956
种属内	SAXO1	Q8IYX7	LMO1	Homo sapiens	P25800	Validated Y2H	25416956
种属内	SAXO1	Q8IYX7	CRK	Homo sapiens	P46108	Y2H Array	25416956
种属内	SAXO1	Q8IYX7	CRK	Homo sapiens	P46108	Y2H Prey Pooling	25416956
种属内	SAXO1	Q8IYX7	OSGIN1	Homo sapiens	Q9UJX0	Y2H Prey Pooling	25416956
种属内	SAXO1	Q8IYX7	OSGIN1	Homo sapiens	Q9UJX0	Validated Y2H	25416956
种属内	SAXO1	Q8IYX7	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183
种属内	SAXO1	Q8IYX7	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12461	SAXO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SAXO1	VGNC	VGNC:34301
Mus musculus	SAXO1	MGD	MGI:1923061
Canis familiaris	SAXO1	VGNC	VGNC:45878
Macaca mulatta	SAXO1	VGNC	VGNC:77114
Rattus norvegicus	SAXO1	RGD	RGD:1583685
Felis catus	SAXO1	VGNC	VGNC:64883

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4