2. Gene
  3. GLYCTK - glycerate kinase Gene

GLYCTK - glycerate kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：甘油酸激酶

种属: Homo sapiens

同用名: HBEBP2; HBEBP4; HBeAgBP4A

基因 ID: 132158 | 基因类型: protein coding

关于 GLYCTK

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:52,287,828-52,295,257 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and is associated with 2 phenotypes. Broad expression in liver (RPKM 19.7), duodenum (RPKM 15.1) and 14 other tissues.

功能概要

该基因座编码甘油酸激酶 2 型家族的成员。编码的酶催化 (R) -甘油酸的磷酸化，并可能参与丝氨酸降解和果糖代谢。编码酶的活性降低可能与 D-甘油酸尿症有关。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2009 年 1 月]

This locus encodes a member of the glycerate kinase type-2 family. The encoded Enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded Enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

GLYCTK 基因产物(2)

mRNA Protein Name
NM_001144951.2 NP_001138423.1 glycerate kinase isoform 2
NM_145262.4 NP_660305.2 glycerate kinase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycerate kinase activity EXP
EXP: 通过实验结果推断
2537226 GOA
enables glycerate kinase activity IDA
IDA: 通过直接分析推断
16753811 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
16753811 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16753811 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GLYCTK 蛋白结构

DUF4147

DUF4147: Domain of unknown function (DUF4147) (37 - 290)

MOFRL

MOFRL: MOFRL family (401 - 514)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 523 a.a.
蛋白主名 其他名称

glycerate kinase

HBeAg binding protein 4

GLYCTK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GLYCTK Q8IVS8 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra GLYCTK Q8IVS8 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 METTL15 Homo sapiens A6NJ78-4
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 METTL15 Homo sapiens A6NJ78-4
Y2H Array
32296183
Intra GLYCTK Q8IVS8 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra GLYCTK Q8IVS8 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra GLYCTK Q8IVS8 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra GLYCTK Q8IVS8 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 TUBGCP4 Homo sapiens Q9UGJ1
Y2H Prey Pooling
25416956
Intra GLYCTK Q8IVS8 TUBGCP4 Homo sapiens Q9UGJ1
Validated Y2H
25416956
Intra GLYCTK Q8IVS8 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra GLYCTK Q8IVS8 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 MIS18A Homo sapiens Q9NYP9
Y2H Array
32296183
Intra GLYCTK Q8IVS8 MIS18A Homo sapiens Q9NYP9
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 MIS18A Homo sapiens Q9NYP9
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 ZFP90 Homo sapiens Q8TF47
Y2H Array
32296183
Intra GLYCTK Q8IVS8 ZFP90 Homo sapiens Q8TF47
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 ZFP90 Homo sapiens Q8TF47
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 SPAG8 Homo sapiens Q99932-2
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 SPAG8 Homo sapiens Q99932-2
Y2H Array
32296183
Intra GLYCTK Q8IVS8 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra GLYCTK Q8IVS8 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 ZIM2 Homo sapiens Q9NZV7
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 ZIM2 Homo sapiens Q9NZV7
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 ZIM2 Homo sapiens Q9NZV7
Y2H Array
32296183
Intra GLYCTK Q8IVS8 ACTMAP Homo sapiens Q5BKX5-3
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 ACTMAP Homo sapiens Q5BKX5-3
Y2H Array
32296183
Intra GLYCTK Q8IVS8 UFSP1 Homo sapiens Q6NVU6
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 UFSP1 Homo sapiens Q6NVU6
Y2H Array
32296183
Intra GLYCTK Q8IVS8 POMC Homo sapiens P01189
Y2H Array
32296183
Intra GLYCTK Q8IVS8 POMC Homo sapiens P01189
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 KRT13 Homo sapiens P13646
Y2H Array
32296183
Intra GLYCTK Q8IVS8 KRT13 Homo sapiens P13646
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 SMUG1 Homo sapiens Q53HV7-2
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 SMUG1 Homo sapiens Q53HV7-2
Y2H Array
32296183
Intra GLYCTK Q8IVS8 PUDP Homo sapiens Q08623
Y2H Array
32296183
Intra GLYCTK Q8IVS8 PUDP Homo sapiens Q08623
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 ATP23 Homo sapiens Q9Y6H3
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 ATP23 Homo sapiens Q9Y6H3
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 ATP23 Homo sapiens Q9Y6H3
Y2H Array
32296183
Intra GLYCTK Q8IVS8 ANKRD53 Homo sapiens Q8N9V6-2
Y2H Array
32296183
Intra GLYCTK Q8IVS8 ANKRD53 Homo sapiens Q8N9V6-2
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 ANKRD53 Homo sapiens Q8N9V6-2
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 NOTO Homo sapiens A8MTQ0
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 NOTO Homo sapiens A8MTQ0
Y2H Array
32296183
Intra GLYCTK Q8IVS8 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra GLYCTK Q8IVS8 RBCK1 Homo sapiens Q9BYM8
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 RBCK1 Homo sapiens Q9BYM8
Y2H Array
32296183
Intra GLYCTK Q8IVS8 RBCK1 Homo sapiens Q9BYM8
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra GLYCTK Q8IVS8 PLAGL2 Homo sapiens Q9UPG8
Y2H Array
32296183
Intra GLYCTK Q8IVS8 PLAGL2 Homo sapiens Q9UPG8
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 PLAGL2 Homo sapiens Q9UPG8
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra GLYCTK Q8IVS8 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Y2H Pooling
19060904
Intra GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
Intra GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Validated Y2H
25416956
Intra GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Y2H Array
19060904
Intra GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Y2H Array
25416956
Intra GLYCTK Q8IVS8 SAXO1 Homo sapiens Q8IYX7
Y2H Array
25416956
Intra GLYCTK Q8IVS8 PRDM14 Homo sapiens Q9GZV8
Y2H Array
32296183
Intra GLYCTK Q8IVS8 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra GLYCTK Q8IVS8 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 ZNF688 Homo sapiens P0C7X2
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 ZNF688 Homo sapiens P0C7X2
Y2H Array
32296183
Intra GLYCTK Q8IVS8 SPRED1 Homo sapiens Q7Z699
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 SPRED1 Homo sapiens Q7Z699
Y2H Array
32296183
Intra GLYCTK Q8IVS8 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
25416956
Intra GLYCTK Q8IVS8 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
25416956
Intra GLYCTK Q8IVS8 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra GLYCTK Q8IVS8 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra GLYCTK Q8IVS8 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra GLYCTK Q8IVS8 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra GLYCTK Q8IVS8 ARMC5 Homo sapiens Q96C12
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 ARMC5 Homo sapiens Q96C12
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 ARMC5 Homo sapiens Q96C12
Y2H Array
32296183
Intra GLYCTK Q8IVS8 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra GLYCTK Q8IVS8 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra GLYCTK Q8IVS8 KRT15 Homo sapiens P19012
Y2H Array
25416956
Intra GLYCTK Q8IVS8 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra GLYCTK Q8IVS8 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra GLYCTK Q8IVS8 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra GLYCTK Q8IVS8 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
25416956
Intra GLYCTK Q8IVS8 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra GLYCTK Q8IVS8 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra GLYCTK Q8IVS8 NT5C2 Homo sapiens P49902
Y2H Array
32296183
Intra GLYCTK Q8IVS8 NT5C2 Homo sapiens P49902
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra GLYCTK Q8IVS8 ZG16 Homo sapiens O60844
Y2H Array
32296183
Intra GLYCTK Q8IVS8 ZG16 Homo sapiens O60844
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 SNF8 Homo sapiens Q96H20
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 SNF8 Homo sapiens Q96H20
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 SNF8 Homo sapiens Q96H20
Y2H Array
32296183
Intra GLYCTK Q8IVS8 SERTAD1 Homo sapiens Q9UHV2
Y2H Array
32296183
Intra GLYCTK Q8IVS8 SERTAD1 Homo sapiens Q9UHV2
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 SERTAD1 Homo sapiens Q9UHV2
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 GMPPB Homo sapiens Q9Y5P6
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 GMPPB Homo sapiens Q9Y5P6
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 GMPPB Homo sapiens Q9Y5P6
Y2H Array
32296183
Intra GLYCTK Q8IVS8 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra GLYCTK Q8IVS8 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 METTL27 Homo sapiens Q8N6F8
Y2H Array
32296183
Intra GLYCTK Q8IVS8 METTL27 Homo sapiens Q8N6F8
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 IHO1 Homo sapiens Q8IYA8
Validated Y2H
32296183
Intra GLYCTK Q8IVS8 IHO1 Homo sapiens Q8IYA8
Y2H Array
32296183
Intra GLYCTK Q8IVS8 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 MORN3 Homo sapiens Q6PF18
Y2H Prey Pooling
32296183
Intra GLYCTK Q8IVS8 MORN3 Homo sapiens Q6PF18
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
D-Glyceric Aciduria

D-Glyceric Acidemia

D-Glycericacidemia

Glycerate Kinase Deficiency

D-Glycerate Kinase Deficiency

Non Ketotic Hyperglycinemia Syndrome

Deficiency Of Glycerate Kinase

Hyperglycinemia, Non-Ketotic

D-GA
Hyperoxaluria, Primary, Type Ii

Primary Hyperoxaluria Type 2

D-Glycerate Dehydrogenase Deficiency

Glyoxylate Reductase/Hydroxypyruvate Reductase Deficiency

HP2

Oxalosis Ii

Glyceric Aciduria

L-Glyceric Aciduria

Primary Hyperoxaluria, Type Ii

Oxalosis 2

Hyperoxaluria Primary 2

Hyperoxaluria Primary Type Ii

Ph2

Primary Hyperoxaluria Type Ii
Ureterolithiasis

Calculus Of Ureter

Ureteric Stone

Ureteral Calculi

Ureteric Calculus

Stone In The Ureter

Ureter Calculi

Ureteral Calculus Or Stone

Ureterolith

Ureterolithiasis Nos
Glycine Encephalopathy

Non-Ketotic Hyperglycinemia

Nonketotic Hyperglycinemia

NKH

GCE

Hyperglycinemia, Nonketotic

Hyperglycinemia Nonketotic

Infantile Glycine Encephalopathy

Encephalopathy, Glycine

Glycine Synthase Deficiency

Nka

Neonatal Glycine Encephalopathy

Classic Glycine Encephalopathy

Neonatal Nkh

Neonatal Non-Ketotic Hyperglycinemia

Infantile Nkh

Infantile Non-Ketotic Hyperglycinemia

Non-Ketotic Hyperglycinaemia

Glycine Cleavage Deficiency

Nonketotic Hyperglycinaemia
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05511 GLYCTK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GLYCTK VGNC VGNC:62601
Bos taurus GLYCTK VGNC VGNC:29429
Mus musculus GLYCTK MGD MGI:2444085
Rattus norvegicus GLYCTK RGD RGD:1591498
Canis familiaris GLYCTK VGNC VGNC:97199
Macaca mulatta GLYCTK VGNC VGNC:72993
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