1. Gene
  2. UFSP1 - UFM1 specific peptidase 1 (inactive) Gene

UFSP1 - UFM1 specific peptidase 1 (inactive) Gene

中文名称:UFM1 特异性肽酶 1 (无活性)

种属: Homo sapiens

同用名: UFSP

基因 ID: 402682 | 基因类型: protein coding

关于 UFSP1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,888,721-100,889,715 (from NCBI)

This gene has 2 transcripts (splice variants), 148 orthologues and 1 paralogue.

功能概要

该基因编码的蛋白质类似于其他 Ufm1 特异性蛋白酶。小鼠研究确定 Ufsp1 从其结合的共轭复合物中释放 Ufm1 (泛素折叠修饰剂 1) ,这也使其成为活性形式。由于人类 UFSP1 蛋白的 N 末端较短并且缺少保守的 Cys 活性位点,因此预计它是无功能的。[RefSeq 提供,2009 年 11 月]

This gene encodes a protein that is similar to Other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009]

UFSP1 基因产物(1)

mRNA Protein Name
NM_001015072.4 NP_001015072.2 inactive Ufm1-specific protease 1

UFSP1 蛋白结构

Peptidase_C78

Peptidase_C78: Peptidase family C78 (7 - 128)

  • 0
  • 100
  • 142 a.a.
蛋白主名 其他名称

inactive Ufm1-specific protease 1

UFM1-specific peptidase 1 (non-functional)

UFSP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UFSP1 Q6NVU6 MSRB3 Homo sapiens Q8IXL7-2
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 TCF7L2 Homo sapiens Q9NQB0-10
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 RBPMS2 Homo sapiens Q6ZRY4
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 HSF4 Homo sapiens Q9ULV5-2
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 VAX2 Homo sapiens Q9UIW0
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 PITX2 Homo sapiens Q99697-2
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 CIDEC Homo sapiens Q96AQ7
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
种属内
UFSP1 Q6NVU6 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
种属内
UFSP1 Q6NVU6 FANCL Homo sapiens Q9NW38
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 FAM222B Homo sapiens Q8WU58
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 GPSM3 Homo sapiens Q9Y4H4
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 SMARCC1 Homo sapiens Q92922
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 COG6 Homo sapiens Q9Y2V7
Y2H Prey Pooling
32296183
种属内
UFSP1 Q6NVU6 COG6 Homo sapiens Q9Y2V7
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 COG6 Homo sapiens Q9Y2V7
Y2H Array
32296183
种属内
UFSP1 Q6NVU6 MYOZ3 Homo sapiens Q8TDC0
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
种属内
UFSP1 Q6NVU6 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
种属内
UFSP1 Q6NVU6 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
种属内
UFSP1 Q6NVU6 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
种属内
UFSP1 Q6NVU6 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 GLYCTK Homo sapiens Q8IVS8
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
种属内
UFSP1 Q6NVU6 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属内
UFSP1 Q6NVU6 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Beukes Hip Dysplasia

Hip Dysplasia, Beukes Type

Beukes Familial Hip Dysplasia

BFHD

Cilliers-Beighton Syndrome

Osteoarthropathy, Premature Degenerative, Of Hip

Premature Degenerative Osteoarthropathy Of The Hip

BHD

Beukes Type Hip Dysplasia

Hip Dysplasia Beukes Type

Premature Degenerative Osteoarthropathy

Dysplasia, Hip, Beukes Type

Spinocerebellar Ataxia, Autosomal Recessive 24

SCAR24

Autosomal Recessive Spinocerebellar Ataxia 24

Spinocerebellar Ataxia, Autosomal Recessive, 24

Ataxia, Spinocerebellar, Autosomal Recessive, Type 24

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus UFSP1 VGNC VGNC:107826
Mus musculus UFSP1 MGD MGI:1917490
Rattus norvegicus UFSP1 RGD RGD:7536909
Macaca mulatta UFSP1 VGNC VGNC:81787
Others UFSP1 NCBI