CIDEC - cell death inducing DFFA like effector c Gene

中文名称：细胞死亡诱导 DFFA 样效应子 c

种属: Homo sapiens

同用名: CIDE3; FPLD5; FSP27; CIDE-3

基因 ID: 63924 | 基因类型: protein coding

关于 CIDEC

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,866,710-9,880,253 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues, 3 paralogues and is associated with 2 phenotypes. Biased expression in fat (RPKM 484.8), small intestine (RPKM 36.2) and 1 other tissue.

功能概要

该基因编码细胞死亡诱导 DNA 片段化因子样效应子家族的成员。该家族的成员在细胞凋亡中起重要作用。编码的蛋白质促进脂肪细胞中脂滴的形成，并可能介导脂肪细胞凋亡。该基因受胰岛素调控，其表达与胰岛素敏感性呈正相关。该基因的突变可能导致胰岛素抵抗性糖尿病。该基因的假基因位于 3 号染色体的短臂上。已观察到该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in Apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte Apoptosis. This gene is regulated by Insulin and its expression is positively correlated with Insulin sensitivity. Mutations in this gene may contribute to Insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

CIDEC 基因产物(8)

mRNA	Protein	Name
NM_001199551.2	NP_001186480.1	cell death activator CIDE-3 isoform 2
NM_001199552.2	NP_001186481.1	cell death activator CIDE-3 isoform 3
NM_001199623.2	NP_001186552.1	cell death activator CIDE-3 isoform 1
NM_001321142.2	NP_001308071.1	cell death activator CIDE-3 isoform 3
NM_001321143.2	NP_001308072.1	cell death activator CIDE-3 isoform 4
NM_001321144.2	NP_001308073.1	cell death activator CIDE-3 isoform 4
NM_001378491.1	NP_001365420.1	cell death activator CIDE-3 isoform 3
NM_022094.3	NP_071377.2	cell death activator CIDE-3 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within apoptotic process	IDA IDA: 通过直接分析推断	12429024	GOA
involved in execution phase of apoptosis	IDA IDA: 通过直接分析推断	12429024	GOA
involved in lipid droplet fusion	IDA IDA: 通过直接分析推断	23399566	GOA
involved in lipid droplet organization	IMP IMP: 通过突变表型推断	20049731	GOA
involved in lipid storage	IDA IDA: 通过直接分析推断	18334488	GOA
involved in negative regulation of lipid catabolic process	IDA IDA: 通过直接分析推断	18334488	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	12429024	GOA
is active in lipid droplet	IDA IDA: 通过直接分析推断	23399566	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CIDEC 蛋白结构

CIDE-N

0
100
200
238 a.a.

蛋白主名

其他名称

cell death activator CIDE-3

fat specific protein 27

CIDEC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CIDEC	Q96AQ7	METTL15	Homo sapiens	A6NJ78-4	Y2H Prey Pooling	32296183
种属内	CIDEC	Q96AQ7	METTL15	Homo sapiens	A6NJ78-4	Y2H Array	32296183
种属内	CIDEC	Q96AQ7	KLHL20	Homo sapiens	Q9BS75	Y2H Array	32296183
种属内	CIDEC	Q96AQ7	KLHL20	Homo sapiens	Q9BS75	Y2H Prey Pooling	32296183
种属内	CIDEC	Q96AQ7	KLHL20	Homo sapiens	Q9BS75	Validated Y2H	32296183
种属内	CIDEC	Q96AQ7	SPATA12	Homo sapiens	Q7Z6I5	Y2H Prey Pooling	32296183
种属内	CIDEC	Q96AQ7	SPATA12	Homo sapiens	Q7Z6I5	Y2H Array	32296183
种属内	CIDEC	Q96AQ7	UFSP1	Homo sapiens	Q6NVU6	Y2H Prey Pooling	32296183
种属内	CIDEC	Q96AQ7	UFSP1	Homo sapiens	Q6NVU6	Y2H Array	32296183
种属内	CIDEC	Q96AQ7	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
种属内	CIDEC	Q96AQ7	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
种属内	CIDEC	Q96AQ7	NR0B2	Homo sapiens	Q15466	Y2H Prey Pooling	32296183
种属内	CIDEC	Q96AQ7	NR0B2	Homo sapiens	Q15466	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

CIDEC 抗体

目录号	产品名	应用	反应物种
HY-P81068	CIDEC Antibody (YA911)	WB, ICC/IF, FC	Human
HY-P81068A	CIDEC/FSP27 Antibody	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat

关联疾病

疾病名称

别名

Lipodystrophy, Familial Partial, Type 5

FPLD5	Cidec-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 5	Cidec-Related Fpld
Familial Partial Lipodystrophy Associated With Cidec Mutations	Lipodystrophy, Familial Partial, Associated With Cidec Mutations
Lipodystrophy, Familial Partial, 5

Lipodystrophy, Familial Partial, Type 4

FPLD4	Plin1-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 4	Familial Partial Lipodystrophy Associated With Plin1 Mutations
Plin1-Related Fpld	Lipodystrophy, Familial Partial, Associated With Plin1 Mutations
Lipodystrophy, Familial Partial, 4

Familial Partial Lipodystrophy

Lipodystrophy, Familial Partial	Fpld
Kobberling-Dunnigan Syndrome	Dunnigan Syndrome
Koberling-Dunnigan Syndrome	Dunnigan-Kobberling Syndrome
Fpl	Familial Partial Lipodystrophy, Type 2

Lipodystrophy, Familial Partial, Type 1

FPLD1	Familial Partial Lipodystrophy Type 1
Familial Partial Lipodystrophy, Kobberling Type	Lipodystrophy, Familial Partial, Kobberling Type
Familial Partial Lipodystrophy Kobberling Type	Familial Partial Lipodystrophy Type Köbberling
Familial Partial Lipodystrophy, Köbberling Type	Familial Partial Lipodystrophy, Type 1

Lipodystrophy, Familial Partial, Type 2

FPLD2	Lipoatrophic Diabetes
Familial Partial Lipodystrophy Type 2	Familial Partial Lipodystrophy, Dunnigan Type
Fpl2	Lipoatrophic Diabetes Mellitus
Lipodystrophy, Familial Partial, Dunnigan Type	Lipodystrophy, Familial, Of Limbs And Lower Trunk
Lipodystrophy, Reverse Partial	Familial Partial Lipodystrophy Dunnigan Type
Dunnigan Syndrome	Familial Lipodystrophy Of Limbs And Lower Trunk
Reverse Partial Lipodystrophy	Lipodystrophy, Familial Partial, 2
Generalized Lipoatrophy Associated With Diabetes, Hepatic Steatosis, Hypertrophic Cardiomyopathy And Leukomelanodermic Papules	Lipodystrophy Familial Of Limbs And Lower Trunk
Lipodystrophy Reverse Partial	Diabetes Mellitus, Lipoatrophic
Familial Partial Lipodystrophy, Type 2	Familial Generalized Lipodystrophy

Lipodystrophy, Familial Partial, Type 3

FPLD3	Pparg-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 3	Familial Partial Lipodystrophy Associated With Pparg Mutations
Pparg-Related Fpld	Lipodystrophy, Familial Partial, Associated With Pparg Mutations
Insulin Resistance, Severe, Digenic	Lipodystrophy, Familial Partial, 3
Familial Partial Lipodystrophy, Type 3

Lipodystrophy, Familial Partial, Type 6

FPLD6	Lipe-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 6	Lipe-Related Fpld
Lipodystrophy, Familial Partial, Associated With Lipe Mutations	Familial Partial Lipodystrophy Associated With Lipe Mutations
Lipodystrophy, Familial Partial, 6

Acquired Generalized Lipodystrophy

Lawrence Syndrome	Acquired Lipoatrophic Diabetes
Lawrence-Seip Syndrome	Familial Generalized Lipodystrophy

Complete Generalized Lipodystrophy

Adiposis Dolorosa

Dercum Disease	Dercum'S Disease
Lipomatosis Dolorosa	Adiposalgia
Adipose Tissue Rheumatism	Anders Syndrome
Dercum-Vitaut Syndrome	Morbus Dercum

Nodular Nonsuppurative Panniculitis

Weber-Christian Disease	Relapsing Febrile Nodular Nonsuppurative Panniculitis
Idiopathic Nodular Panniculitis	Pfeiffer-Weber-Christian Syndrome
Weber-Christian Panniculitis	Panniculitis, Nodular Nonsuppurative
Nodular Non-Suppurative Febrile Panniculitis	Weber - Christian Disease
Panniculitis Nodular Nonsuppurative	Nodular Non-Suppurative Panniculitis
Idiopathic Lobular Panniculitis	Relapsing Febrile Nodular Panniculitis
Wcd

Lipodystrophy, Congenital Generalized, Type 2

Congenital Generalized Lipodystrophy Type 2	CGL2
Berardinelli-Seip Congenital Lipodystrophy Type 2	Berardinelli-Seip Syndrome
Brunzell Syndrome Bscl2-Related	Total Lipodystrophy And Acromegaloid Gigantism
Berardinelli-Seip Congenital Lipodystrophy, Type 2	Seip Syndrome
Berardinelli Syndrome	Lipodystrophy, Total, And Acromegaloid Gigantism
Lipoatrophic Diabetes, Congenital	Lipodystrophy, Berardinelli-Seip Congenital, Type 2
Brunzell Syndrome, Bscl2-Related	Congenital Lipoatrophic Diabetes
Congenital Generalized Lipodystrophy 2	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02713	CIDEC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CIDEC	VGNC	VGNC:60902
Mus musculus	CIDEC	MGD	MGI:95585
Rattus norvegicus	CIDEC	RGD	RGD:1562113
Canis familiaris	CIDEC	VGNC	VGNC:39272
Bos taurus	CIDEC	VGNC	VGNC:27365
Macaca mulatta	CIDEC	VGNC	VGNC:71332

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