2. Gene
  3. SNF8 - SNF8 subunit of ESCRT-II Gene

SNF8 - SNF8 subunit of ESCRT-II Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ESCRT-II 的 SNF8 亚基

种属: Homo sapiens

同用名: Dot3; EAP30; VPS22

基因 ID: 11267 | 基因类型: protein coding

关于 SNF8

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,929,316-48,944,842 (from NCBI)

This gene has 17 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in kidney (RPKM 18.5), fat (RPKM 18.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是转运 II (ESCRT-II) 所需的内体分选复合体的一个组成部分，它调节泛素化跨膜蛋白向溶酶体降解的运动。该复合物还与 RNA 聚合酶 II 延伸因子 (ELL) 相互作用，以克服 ELL 对 RNA 聚合酶 II 活性的抑制作用。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

SNF8 基因产物(4)

mRNA Protein Name
NM_001317192.2 NP_001304121.1 vacuolar-sorting protein SNF8 isoform 2
NM_001317193.2 NP_001304122.1 vacuolar-sorting protein SNF8 isoform 3
NM_001317194.2 NP_001304123.1 vacuolar-sorting protein SNF8 isoform 4
NM_007241.4 NP_009172.2 vacuolar-sorting protein SNF8 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables channel regulator activity IDA
IDA: 通过直接分析推断
23171048 GOA
enables lipid binding IPI
IPI: 通过物理相互作用推断
18539118 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14505570 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
14505570 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in early endosome to late endosome transport IMP
IMP: 通过突变表型推断
17714434 GOA
involved in endocytic recycling IMP
IMP: 通过突变表型推断
17714434 GOA
involved in macroautophagy IMP
IMP: 通过突变表型推断
38423010 GOA
involved in multivesicular body assembly IMP
IMP: 通过突变表型推断
38423010 GOA
involved in multivesicular body sorting pathway IMP
IMP: 通过突变表型推断
38423010 GOA
involved in positive regulation of exosomal secretion IMP
IMP: 通过突变表型推断
22660413 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
22978549 GOA
involved in positive regulation of protein catabolic process IMP
IMP: 通过突变表型推断
17959629 GOA
NOT involved in regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
17714434 GOA
involved in regulation of protein catabolic process IMP
IMP: 通过突变表型推断
17714434 GOA
involved in regulation of protein complex stability IMP
IMP: 通过突变表型推断
17714434 GOA
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10419521 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ESCRT II complex IDA
IDA: 通过直接分析推断
16973552 GOA
part of ESCRT II complex IPI
IPI: 通过物理相互作用推断
18539118 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
22978549 GOA
located in cytosol IDA
IDA: 通过直接分析推断
17010938 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
16973552 GOA
located in late endosome membrane IDA
IDA: 通过直接分析推断
17010938 GOA
located in membrane IDA
IDA: 通过直接分析推断
23171048 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23171048 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
17714434 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
22978549 GOA
located in recycling endosome IDA
IDA: 通过直接分析推断
17714434 GOA
part of transcription regulator complex IDA
IDA: 通过直接分析推断
10419521 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNF8 蛋白结构

EAP30

EAP30: EAP30/Vps36 family (6 - 225)

  • 0
  • 100
  • 200
  • 258 a.a.
蛋白主名 其他名称

vacuolar-sorting protein SNF8

EAP30 subunit of ELL complex

SNF8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SNF8 Q96H20 AKAP9 Homo sapiens Q6PJH3
Y2H Prey Pooling
32296183
Intra SNF8 Q96H20 AKAP9 Homo sapiens Q6PJH3
Y2H Array
32296183
Intra SNF8 Q96H20 ELL Homo sapiens P55199
Anti Tag CoIP
19819239
Intra SNF8 Q96H20 ELL Homo sapiens P55199
Competition Binding
19819239
Intra SNF8 Q96H20 VAC14 Homo sapiens Q08AM6
Y2H Array
29892012
Intra SNF8 Q96H20 VAC14 Homo sapiens Q08AM6
Validated Y2H
25416956
Intra SNF8 Q96H20 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra SNF8 Q96H20 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra SNF8 Q96H20 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
Intra SNF8 Q96H20 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra SNF8 Q96H20 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra SNF8 Q96H20 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra SNF8 Q96H20 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra SNF8 Q96H20 FANCL Homo sapiens Q9NW38
Validated Y2H
32296183
Intra SNF8 Q96H20 STAU1 Homo sapiens O95793-2
Anti Tag CoIP
22978549
Intra SNF8 Q96H20 STAU1 Homo sapiens O95793-2
Complementation
22978549
Intra SNF8 Q96H20 MCM2 Homo sapiens P49736
Y2H
19819239
Intra SNF8 Q96H20 VPS36 Homo sapiens Q86VN1
Anti Tag CoIP
35271311
Intra SNF8 Q96H20 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra SNF8 Q96H20 CT55 Homo sapiens Q8WUE5
Y2H Prey Pooling
32296183
Intra SNF8 Q96H20 CT55 Homo sapiens Q8WUE5
Y2H Array
32296183
Intra SNF8 Q96H20 KDM1A Homo sapiens O60341
Y2H
23455924
Intra SNF8 Q96H20 CASP6 Homo sapiens P55212
Validated Y2H
32814053
Intra SNF8 Q96H20 CASP6 Homo sapiens P55212
Y2H Array
32814053
Intra SNF8 Q96H20 CASP6 Homo sapiens P55212
Y2H Pooling
32814053
Intra SNF8 Q96H20 VPS25 Homo sapiens Q9BRG1
Anti Tag CoIP
35271311
Intra SNF8 Q96H20 VPS25 Homo sapiens Q9BRG1
Y2H Array
29892012
Intra SNF8 Q96H20 VPS25 Homo sapiens Q9BRG1
Y2H Pooling
16189514
Intra SNF8 Q96H20 VPS25 Homo sapiens Q9BRG1
Y2H Array
31515488
Intra SNF8 Q96H20 VPS25 Homo sapiens Q9BRG1
Y2H Prey Pooling
25416956
Intra SNF8 Q96H20 VPS25 Homo sapiens Q9BRG1
Y2H Prey Pooling
32296183
Intra SNF8 Q96H20 VPS25 Homo sapiens Q9BRG1
Validated Y2H
32296183
Intra SNF8 Q96H20 VPS25 Homo sapiens Q9BRG1
Y2H Array
25416956
Intra SNF8 Q96H20 VPS25 Homo sapiens Q9BRG1
Y2H Array
32296183
Intra SNF8 Q96H20 PRMT6 Homo sapiens Q96LA8
Y2H
23455924
Intra SNF8 Q96H20 PRMT6 Homo sapiens Q96LA8
Anti Tag CoIP
23455924
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13490 SNF8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SNF8 RGD RGD:1310144
Felis catus SNF8 VGNC VGNC:99457
Macaca mulatta SNF8 VGNC VGNC:77729
Mus musculus SNF8 MGD MGI:1343161
Canis familiaris SNF8 VGNC VGNC:46601
Bos taurus SNF8 VGNC VGNC:35064
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