2. Gene
  3. ELL - elongation factor for RNA polymerase II Gene

ELL - elongation factor for RNA polymerase II Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RNA 聚合酶 II 的延伸因子

种属: Homo sapiens

同用名: MEN; ELL1; PPP1R68; C19orf17

基因 ID: 8178 | 基因类型: protein coding

关于 ELL

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,442,663-18,522,070 (from NCBI)

This gene has 6 transcripts (splice variants), 252 orthologues, 5 paralogues and is associated with 61 phenotypes. Broad expression in bone marrow (RPKM 9.4), testis (RPKM 9.4) and 25 other tissues.

功能概要

启用磷酸酶结合活性。参与转录、DNA 模板化和 snRNA 转录的正调控。位于胞质溶胶中；核体；和转录活性染色质。转录延伸因子复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables Phosphatase binding activity. Involved in positive regulation of transcription, DNA-templated and snRNA transcription. Located in cytosol; nuclear body; and transcriptionally active chromatin. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]

ELL 基因产物(1)

mRNA Protein Name
NM_006532.4 NP_006523.1 RNA polymerase II elongation factor ELL
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatase binding IDA
IDA: 通过直接分析推断
19389623 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19389623 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase III IMP
IMP: 通过突变表型推断
23932780 GOA
involved in positive regulation of transcription elongation by RNA polymerase II IMP
IMP: 通过突变表型推断
23932780 GOA
involved in snRNA transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22195968 GOA
involved in snRNA transcription by RNA polymerase III IMP
IMP: 通过突变表型推断
23932780 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Cajal body IDA
IDA: 通过直接分析推断
22195968 GOA
located in euchromatin IDA
IDA: 通过直接分析推断
23932780 GOA
located in histone locus body IDA
IDA: 通过直接分析推断
23932780 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
19389623 GOA
part of transcription elongation factor complex IDA
IDA: 通过直接分析推断
22195968 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ELL 蛋白结构

ELL

ELL: RNA polymerase II elongation factor ELL (6 - 292)

Occludin_ELL

Occludin_ELL: Occludin homology domain (513 - 614)

  • 0
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  • 500
  • 621 a.a.
蛋白主名 其他名称

RNA polymerase II elongation factor ELL

ELL gene (11-19 lysine-rich leukemia gene)

ELL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ELL P55199 PPP1CA Homo sapiens P62136
Pull Down
19389623
种属内
ELL P55199 PPP1CA Homo sapiens P62136
Far-WB
19389623
种属内
ELL P55199 ICE2 Homo sapiens Q659A1
Anti Tag CoIP
22195968
种属内
ELL P55199 SNF8 Homo sapiens Q96H20
Pull Down
19819239
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Acute Biphenotypic Leukemia

Mixed Phenotype Acute Leukemia

Acute Leukemia Of Ambiguous Lineage

Acute Undifferentiated Leukemia

Acute Leukemia Of Indeterminate Lineage

Hybrid Acute Leukemia

Mixed Lineage Acute Leukemia

All With Myeloid Markers

Aml With Lymphoid Markers

Acute Leukemia Of Undetermined Lineage

Bal

Biphenotypic Acute Leukemia

Undifferentiated Acute Leukemia

Mpal

Acute Myeloid Leukemia, Minimal Differentiation, Fab M0

Leukemia, Biphenotypic, Acute
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W019980D Cobalt (ll) chloride hexahydrate, for cell culture / 否
HY-Y0329G Iron(III) nitrate nonahydrate, for cell culture / 否
HY-Y1110I Magnesium chloride, for insect cell culture, 97% / 否
HY-136509 CIL62 ≥97.0% 否
HY-RS04308 ELL Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04309 ELL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04310 ELL3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-Y1110H Magnesium chloride anhydrous, suitable for insect cell culture / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ELL VGNC VGNC:40306
Mus musculus ELL MGD MGI:109377
Bos taurus ELL VGNC VGNC:28435
Felis catus ELL VGNC VGNC:61813
Macaca mulatta ELL VGNC VGNC:72088
Rattus norvegicus ELL RGD RGD:1311121
Macaca fascicularis ELL NCBI NCBI:102123499
Canis lupus familiaris ELL NCBI
Susscrofa domestica ELL NCBI
Others ELL NCBI
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