CASP6 - caspase 6 Gene

中文名称：半胱天冬酶 6

种属: Homo sapiens

同用名: MCH2; CSP-6

关于 CASP6

功能概要

该基因编码半胱氨酸-天冬氨酸蛋白酶 (半胱天冬酶) 酶家族的成员。半胱天冬酶的顺序激活在细胞凋亡的执行阶段起着核心作用。半胱天冬酶作为无活性的酶原存在，其在保守的天冬氨酸残基处进行蛋白水解加工以产生大小两个亚基，其二聚化形成活性酶。这种蛋白质由半胱天冬酶 7、8 和 10 加工，被认为在半胱天冬酶激活级联中起下游酶的作用。该基因的可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 10 月]

This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family of Enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active Enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream Enzyme in the Caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]