2. Gene
  3. RING1 - ring finger protein 1 Gene

RING1 - ring finger protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：无名指蛋白 1

种属: Homo sapiens

同用名: RNF1; RING1A

基因 ID: 6015 | 基因类型: protein coding

关于 RING1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,208,500-33,212,716 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 187 orthologues and 7 paralogues. Ubiquitous expression in endometrium (RPKM 22.9), ovary (RPKM 22.0) and 25 other tissues.

功能概要

该基因属于 RING 指家族，其成员编码以 RING 结构域为特征的蛋白质，RING 结构域是与锌指结构域相关的锌结合基序。基因产物可以结合 DNA 并可以作为转录抑制因子。它与多聚体多梳组蛋白复合物有关。基因产物与多梳组蛋白 BMI1、EDR1 和 CBX4 相互作用，并与这些蛋白共定位在大核域中。它通过富含甘氨酸的 C 末端结构域与 CBX4 蛋白相互作用。该基因映射到 HLA II 类区域，与无名指基因 FABGL 和 HKE4 相邻。[RefSeq 提供，2008 年 7 月]

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]

RING1 基因产物(1)

mRNA Protein Name
NM_002931.4 NP_002922.2 E3 ubiquitin-protein ligase RING1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15386022 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
16943429 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9199346 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PRC1 complex IDA
IDA: 通过直接分析推断
12167701 GOA
part of PcG protein complex IDA
IDA: 通过直接分析推断
16943429 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9199346 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RING1 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (48 - 87)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RING1

RING-type E3 ubiquitin transferase RING1

RING1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RING1 Q06587 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
种属内
RING1 Q06587 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
种属内
RING1 Q06587 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
种属内
RING1 Q06587 PCGF6 Homo sapiens Q9BYE7
TAP
27705803
种属内
RING1 Q06587 PCGF6 Homo sapiens Q9BYE7
TAP
24981860
种属内
RING1 Q06587 YAF2 Homo sapiens Q8IY57-5
Y2H Prey Pooling
32296183
种属内
RING1 Q06587 YAF2 Homo sapiens Q8IY57-5
Validated Y2H
32296183
种属内
RING1 Q06587 YAF2 Homo sapiens Q8IY57-5
Y2H Array
32296183
种属内
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8-2
Y2H Array
32296183
种属内
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8-2
Validated Y2H
32296183
种属内
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8-2
Y2H Prey Pooling
32296183
种属内
RING1 Q06587 ZIM3 Homo sapiens Q96PE6
Validated Y2H
32296183
种属内
RING1 Q06587 PCGF2 Homo sapiens P35227
TAP
27705803
种属内
RING1 Q06587 PCGF2 Homo sapiens P35227
TAP
24981860
种属内
RING1 Q06587 PCGF2 Homo sapiens P35227
Anti Tag CoIP
22493164
种属内
RING1 Q06587 PCGF2 Homo sapiens P35227
Y2H Prey Pooling
32296183
种属内
RING1 Q06587 PCGF2 Homo sapiens P35227
Y2H Array
32296183
种属内
RING1 Q06587 PCGF2 Homo sapiens P35227
Anti Tag CoIP
19636380
种属内
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8
Anti Tag CoIP
22493164
种属内
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8
Y2H Array
22493164
种属内
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8
TAP
24981860
种属内
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8
TAP
27705803
种属内
RING1 Q06587 BMI1 Homo sapiens P35226
Y2H Prey Pooling
32296183
种属内
RING1 Q06587 BMI1 Homo sapiens P35226
Y2H Array
22493164
种属内
RING1 Q06587 BMI1 Homo sapiens P35226
Anti Bait CoIP
15386022
种属内
RING1 Q06587 BMI1 Homo sapiens P35226
Anti Bait CoIP
22897849
种属内
RING1 Q06587 BMI1 Homo sapiens P35226
Y2H Array
32296183
种属内
RING1 Q06587 BMI1 Homo sapiens P35226
TAP
24981860
种属内
RING1 Q06587 BMI1 Homo sapiens P35226
TAP
27705803
种属内
RING1 Q06587 BMI1 Homo sapiens P35226
Y2H Prey Pooling
25416956
种属内
RING1 Q06587 BMI1 Homo sapiens P35226
Anti Tag CoIP
22493164
种属内
RING1 Q06587 PCGF5 Homo sapiens Q86SE9
Y2H Prey Pooling
32296183
种属内
RING1 Q06587 PCGF5 Homo sapiens Q86SE9
TAP
27705803
种属内
RING1 Q06587 PCGF5 Homo sapiens Q86SE9
Validated Y2H
32296183
种属内
RING1 Q06587 PCGF5 Homo sapiens Q86SE9
TAP
24981860
种属内
RING1 Q06587 PCGF5 Homo sapiens Q86SE9
Y2H Array
32296183
种属内
RING1 Q06587 YAF2 Homo sapiens Q8IY57
Validated Y2H
25416956
种属内
RING1 Q06587 YAF2 Homo sapiens Q8IY57
TAP
24981860
种属内
RING1 Q06587 YAF2 Homo sapiens Q8IY57
TAP
27705803
种属内
RING1 Q06587 USP7 Homo sapiens Q93009
Pull Down
20601937
种属内
RING1 Q06587 USP7 Homo sapiens Q93009
Anti Tag CoIP
20601937
种属内
RING1 Q06587 USP11 Homo sapiens P51784
Anti Tag CoIP
20601937
种属内
RING1 Q06587 USP11 Homo sapiens P51784
Pull Down
20601937
种属内
RING1 Q06587 TP53 Homo sapiens P04637
IF
29187402
种属内
RING1 Q06587 TP53 Homo sapiens P04637
Anti Bait CoIP
29187402
种属内
RING1 Q06587 TP53 Homo sapiens P04637
Ubiquitinase Assay
29187402
种属内
RING1 Q06587 TP53 Homo sapiens P04637
Anti Tag CoIP
29187402
种属内
RING1 Q06587 CBX7 Homo sapiens O95931
TAP
27705803
种属内
RING1 Q06587 CBX7 Homo sapiens O95931
Anti Tag CoIP
21282530
种属内
RING1 Q06587 CBX6 Homo sapiens O95503
TAP
27705803
种属内
RING1 Q06587 CBX6 Homo sapiens O95503
TAP
24981860
种属内
RING1 Q06587 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
种属内
RING1 Q06587 UBE2K Homo sapiens P61086
Validated Y2H
32814053
种属内
RING1 Q06587 UBE2K Homo sapiens P61086
Y2H Array
32814053
种属内
RING1 Q06587 CBX8 Homo sapiens Q9HC52
TAP
24981860
种属内
RING1 Q06587 CBX8 Homo sapiens Q9HC52
TAP
27705803
种属内
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Pull Down
21282530
种属内
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
21282530
种属内
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Y2H Prey Pooling
25416956
种属内
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
种属内
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Y2H Prey Pooling
32296183
种属内
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Y2H Array
32296183
种属内
RING1 Q06587 RNF2 Homo sapiens Q99496
Anti Bait CoIP
15386022
种属内
RING1 Q06587 RNF2 Homo sapiens Q99496
Pull Down
16943429
种属内
RING1 Q06587 RNF2 Homo sapiens Q99496
Anti Tag CoIP
35271311
种属内
RING1 Q06587 RNF2 Homo sapiens Q99496
TAP
24981860
种属内
RING1 Q06587 UBE2D4 Homo sapiens Q9Y2X8
Validated Y2H
32296183
种属内
RING1 Q06587 UBE2D4 Homo sapiens Q9Y2X8
Y2H Array
19549727
种属内
RING1 Q06587 PCGF1 Homo sapiens Q9BSM1
Pull Down
16943429
种属内
RING1 Q06587 PCGF1 Homo sapiens Q9BSM1
TAP
24981860
种属内
RING1 Q06587 PCGF1 Homo sapiens Q9BSM1
TAP
27705803
种属内
RING1 Q06587 RYBP Homo sapiens Q8N488
TAP
24981860
种属内
RING1 Q06587 RYBP Homo sapiens Q8N488
Validated Y2H
25416956
种属内
RING1 Q06587 RYBP Homo sapiens Q8N488
TAP
27705803
种属内
RING1 Q06587 RYBP Homo sapiens Q8N488
Validated Y2H
32296183
种属内
RING1 Q06587 RYBP Homo sapiens Q8N488
Y2H Array
25416956
种属内
RING1 Q06587 RYBP Homo sapiens Q8N488
MAPPIT
25416956
种属内
RING1 Q06587 RYBP Homo sapiens Q8N488
Anti Tag CoIP
35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

RING1 抗体

目录号 产品名 应用 反应物种
HY-P82606 RING1 Antibody (YA2351) WB, IHC-P, ICC/IF Human

关联疾病

疾病名称 别名
Granulomatosis With Polyangiitis

GPA

Wegener Granulomatosis

Wegener Granulomatosis, Formerly

Midline Granulomatosis

Wg, Formerly

Necrotizing Respiratory Granulomatosis

Wg

Wegeners Granulomatosis

Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Juvenile-Onset Parkinson'S Disease

Juvenile-Onset Parkinson Disease
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139514 RB-3 Inhibitor 99.42% 否
HY-158239 MS181 Inhibitor 98.36% 否
HY-103291 Sar-[D-Phe8]-des-Arg9-Bradykinin Agonist 99.34% 否
HY-RS11985 RING1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-116918 N,N-Diphenylacetamide / 否
HY-117664 PNR-7-02 Inhibitor / 否
HY-129665 GS-389 Inhibitor / 否
HY-138140 Desertomycin A / 否
HY-160562 PROTAC ERα Degrader-7 Degrader / 否
HY-160924 MS147 Inhibitor / 否
HY-N15186 Gymnoascolide A / 否
HY-W507009 L-Arginyl-L-alanine / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus RING1 VGNC VGNC:33977
Macaca mulatta RING1 VGNC VGNC:83457
Rattus norvegicus RING1 RGD RGD:3576
Mus musculus RING1 MGD MGI:1101770
Canis familiaris RING1 VGNC VGNC:45589
Others RING1 NCBI
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