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  2. CBX6 - chromobox 6 Gene

CBX6 - chromobox 6 Gene

中文名称:色盒 6

种属: Homo sapiens

基因 ID: 23466 | 基因类型: protein coding

关于 CBX6

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,861,422-38,872,216 (from NCBI)

This gene has 3 transcripts (splice variants), 109 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 28.2), ovary (RPKM 14.0) and 24 other tissues.

功能概要

预测可实现单链 RNA 结合活性。参与 RNA 聚合酶 II 对转录的负调控。位于核内。 PcG 蛋白复合物的一部分。胶质母细胞瘤的生物标志物。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable single-stranded RNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PcG protein complex. Biomarker of glioblastoma. [provided by Alliance of Genome Resources, Apr 2022]

CBX6 基因产物(2)

mRNA Protein Name
NM_001303494.2 NP_001290423.1 chromobox protein homolog 6 isoform 2
NM_014292.5 NP_055107.3 chromobox protein homolog 6 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18927235 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21282530 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PcG protein complex IDA
IDA: 通过直接分析推断
21282530 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21282530 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CBX6 蛋白结构

Chromo

Chromo: Chromo (CHRromatin Organisation MOdifier) domain (13 - 60)

  • 0
  • 100
  • 200
  • 300
  • 412 a.a.
蛋白主名 其他名称

chromobox protein homolog 6

chromobox homolog 6

CBX6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CBX6 O95503 MOV10 Homo sapiens Q9HCE1
TAP
21282530
Intra CBX6 O95503 MOV10 Homo sapiens Q9HCE1
Anti Tag CoIP
33961781
Intra CBX6 O95503 PCGF2 Homo sapiens P35227
Pull Down
21282530
Intra CBX6 O95503 PCGF3 Homo sapiens Q3KNV8
Anti Tag CoIP
21282530
Intra CBX6 O95503 BMI1 Homo sapiens P35226
TAP
27705803
Intra CBX6 O95503 BMI1 Homo sapiens P35226
TAP
24981860
Intra CBX6 O95503 BMI1 Homo sapiens P35226
Anti Tag CoIP
33961781
Intra CBX6 O95503 BMI1 Homo sapiens P35226
Anti Tag CoIP
21282530
Intra CBX6 O95503 RNF2 Homo sapiens Q99496
TAP
27705803
Intra CBX6 O95503 RNF2 Homo sapiens Q99496
Anti Tag CoIP
33961781
Intra CBX6 O95503 RNF2 Homo sapiens Q99496
TAP
21282530
Intra CBX6 O95503 RNF2 Homo sapiens Q99496
TAP
24981860
Intra CBX6 O95503 PCGF1 Homo sapiens Q9BSM1
Anti Tag CoIP
33961781
Intra CBX6 O95503 RING1 Homo sapiens Q06587
TAP
27705803
Intra CBX6 O95503 RING1 Homo sapiens Q06587
Pull Down
21282530
Intra CBX6 O95503 RING1 Homo sapiens Q06587
Anti Tag CoIP
21282530
Intra CBX6 O95503 RING1 Homo sapiens Q06587
Anti Tag CoIP
33961781
Intra CBX6 O95503 RING1 Homo sapiens Q06587
TAP
21282530
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Benign Pleural Mesothelioma

Mesothelioma Of Pleura

Benign Neoplasm Of Mesothelial Tissue Of Pleura

Pleural Malignant Mesothelioma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CBX6 MGD MGI:3512628
Bos taurus CBX6 VGNC VGNC:26819
Rattus norvegicus CBX6 RGD RGD:1307314