2. Gene
  3. MOV10 - Mov10 RISC complex RNA helicase Gene

MOV10 - Mov10 RISC complex RNA helicase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Mov10 RISC 复杂 RNA 解旋酶

种属: Homo sapiens

同用名: gb110; fSAP113

基因 ID: 4343 | 基因类型: protein coding

关于 MOV10

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,674,439-112,700,739 (from NCBI)

This gene has 26 transcripts (splice variants), 295 orthologues and 10 paralogues. Ubiquitous expression in placenta (RPKM 19.5), small intestine (RPKM 18.6) and 25 other tissues.

功能概要

启用 5'-3' RNA 解旋酶活性和 RNA 结合活性。参与对病毒的防御反应； RNA 介导的转座负调控；和基因表达的转录后调控。位于 P 体和胞质溶胶中。与高血压有关。 [由基因组资源联盟提供，2022 年 4 月]

Enables 5'-3' RNA helicase activity and RNA binding activity. Involved in defense response to virus; negative regulation of transposition, RNA-mediated; and posttranscriptional regulation of gene expression. Located in P-body and cytosol. Implicated in hypertension. [provided by Alliance of Genome Resources, Apr 2022]

MOV10 基因产物(7)

mRNA Protein Name
NM_001130079.3 NP_001123551.1 helicase MOV-10 isoform 1
NM_001286072.2 NP_001273001.1 helicase MOV-10 isoform 2
NM_001321324.2 NP_001308253.1 helicase MOV-10 isoform 1
NM_001369507.1 NP_001356436.1 helicase MOV-10 isoform 1
NM_001389562.1 NP_001376491.1 helicase MOV-10 isoform 2
NM_001389563.1 NP_001376492.1 helicase MOV-10 isoform 2
NM_020963.5 NP_066014.1 helicase MOV-10 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 5'-3' RNA helicase activity IDA
IDA: 通过直接分析推断
24726324 GOA
enables RNA binding IDA
IDA: 通过直接分析推断
23093941 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16289642 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: 通过直接分析推断
24726324 GOA
involved in defense response to virus IMP
IMP: 通过突变表型推断
27974568 GOA
involved in miRNA-mediated gene silencing by mRNA destabilization IDA
IDA: 通过直接分析推断
16289642 GOA
involved in miRNA-mediated post-transcriptional gene silencing IMP
IMP: 通过突变表型推断
17507929 GOA
involved in positive regulation of mRNA catabolic process IDA
IDA: 通过直接分析推断
24726324 GOA
involved in retrotransposon silencing IDA
IDA: 通过直接分析推断
23093941 GOA
involved in retrotransposon silencing by mRNA destabilization IDA
IDA: 通过直接分析推断
30122351 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
16289642 GOA
located in cytoplasmic ribonucleoprotein granule IDA
IDA: 通过直接分析推断
30122351 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MOV10 蛋白结构

AAA_11

AAA_11: AAA domain (499 - 596)

AAA_11

AAA_11: AAA domain (610 - 690)

AAA_12

AAA_12: AAA domain (700 - 922)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1003 a.a.
蛋白主名 其他名称

helicase MOV-10

Mov10, Moloney leukemia virus 10, homolog

MOV10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MOV10 Q9HCE1 IGF2BP1 Homo sapiens Q9NZI8
Anti Tag CoIP
20543829
Cross MOV10 Q9HCE1 Cbx7 Mus musculus Q8VDS3
Pull Down
20543829
Cross MOV10 Q9HCE1 Cbx7 Mus musculus Q8VDS3
Anti Tag CoIP
20543829
Cross MOV10 Q9HCE1 shdag_hdvd3 Hepatitis delta virus P0C6L3
Anti Tag CoIP
18552826
Intra MOV10 Q9HCE1 PCGF2 Homo sapiens P35227
Anti Bait CoIP
20543829
Intra MOV10 Q9HCE1 PCGF2 Homo sapiens P35227
Anti Tag CoIP
20543829
Intra MOV10 Q9HCE1 BMI1 Homo sapiens P35226
Anti Bait CoIP
20543829
Intra MOV10 Q9HCE1 BMI1 Homo sapiens P35226
Anti Tag CoIP
20543829
Cross MOV10 Q9HCE1 N SARS-CoV-2 P0DTC9
Confocal
35107372
Cross MOV10 Q9HCE1 N SARS-CoV-2 P0DTC9
Anti Bait CoIP
35107372
Intra MOV10 Q9HCE1 TIAL1 Homo sapiens Q01085
Anti Bait CoIP
34517762
Intra MOV10 Q9HCE1 CBX7 Homo sapiens O95931
Anti Bait CoIP
20543829
Intra MOV10 Q9HCE1 CBX7 Homo sapiens O95931
Anti Tag CoIP
20543829
Intra MOV10 Q9HCE1 CBX6 Homo sapiens O95503
Anti Tag CoIP
20543829
Intra MOV10 Q9HCE1 EIF2AK2 Homo sapiens P19525
Anti Tag CoIP
21903422
Intra MOV10 Q9HCE1 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
20543829
Intra MOV10 Q9HCE1 CBX8 Homo sapiens Q9HC52
Anti Bait CoIP
20543829
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08603 MOV10 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08604 MOV10L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MOV10 VGNC VGNC:106410
Felis catus MOV10 VGNC VGNC:68302
Mus musculus MOV10 MGD MGI:97054
Canis familiaris MOV10 VGNC VGNC:43327
Bos taurus MOV10 VGNC VGNC:31566
Rattus norvegicus MOV10 RGD RGD:1598327
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